Efficacy of recreational football on bone health, body composition, and physical functioning in men with prostate cancer undergoing androgen deprivation therapy: 32-week follow-up of the FC prostate randomised controlled trial.
Osteoporos Int. 2015 Nov 16; Authors: Uth J, Hornstrup T, Christensen JF, Christensen KB, Jørgensen NR, Schmidt JF, Brasso K, Jakobsen MD, Sundstrup E, Andersen LL, Rørth M, Midtgaard J, Krustrup P, Helge... Lees meer
More than 6 Months of Teriparatide Treatment Was More Effective for Bone Union than Shorter Treatment Following Lumbar Posterolateral Fusion Surgery.
Asian Spine J. 2015 Aug;9(4):573-80. Ohtori S, Orita S, Yamauchi K, Eguchi Y, Ochiai N, Kuniyoshi K, Aoki Y, Nakamura J, Miyagi M, Suzuki M, Kubota G, Inage K, Sainoh T, Sato J, Shiga Y, Abe K, Fujimoto K, Kanamoto H,... Lees meer
Wrist fractures could be predictor of susceptibility to serious fractures in postmenopausal women
Wrist fractures are common among postmenopausal women who are younger than 65 and a new UCLA-led study suggests that they may also predict more serious fractures in other parts of their bodies later in life.
Soybean foods may protect menopausal women against osteoporosis
Eating a diet rich in both soy protein and isoflavones can protect menopausal women from bone weakening and osteoporosis, according to the results of a preliminary study presented at the Society for Endocrinology annual... Lees meer
Three cups of tea a day could help prevent osteoporosis
A daily intake of three cups of black tea could reduce the risk of bone fractures in older people by almost a third, according to new research published in the American Journal of Clinical Nutrition. Lees meer
A meta-analysis of trabecular bone score in fracture risk prediction and its relationship to FRAX.
J Bone Miner Res. 2015 Oct 24; Authors: McCloskey EV, Odén A, Harvey NC, Leslie WD, Hans D, Johansson H, Barkmann R, Boutroy S, Brown J, Chapurlat R, Elders PJ, Fujita Y, Glüer CC, Goltzman D, Iki M, Karlsson M,... Lees meer
Clinical utility of routine laboratory testing to identify possible secondary causes in older men with osteoporosis: the Osteoporotic Fractures in Men (MrOS) Study.
Osteoporos Int. 2015 Oct 12; Authors: Fink HA, Litwack-Harrison S, Taylor BC, Bauer DC, Orwoll ES, Lee CG, Barrett-Connor E, Schousboe JT, Kado DM, Garimella PS, Ensrud KE, Osteoporotic Fractures in Men (MrOS) Study... Lees meer
Effects of Dairy Products Consumption on Health: Benefits and Beliefs-A Commentary from the Belgian Bone Club and the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases.
Calcif Tissue Int. 2015 Oct 7; Authors: Rozenberg S, Body JJ, Bruyère O, Bergmann P, Brandi ML, Cooper C, Devogelaer JP, Gielen E, Goemaere S, Kaufman JM, Rizzoli R, Reginster JY
Effects of zoledronic acid versus placebo on bone mineral density and bone texture analysis assessed by the trabecular bone score in premenopausal women with breast cancer treatment-induced bone loss: results of the ProBONE II substudy.
Osteoporos Int. 2015 Jan;26(1):353-60 Authors: Kalder M, Kyvernitakis I, Albert US, Baier-Ebert M, Hadji P
INTRODUCTION: The aim of this study was to compare the effects of 4 mg intravenous zoledronate (ZOL) versus... Lees meer
New Canadian guideline addresses fracture risk in senior care
Older adults living in long-term care are more than twice as likely as their peers living at home to suffer a fracture, and a new guideline endorsed by the Scientific Advisory Council of Osteoporosis Canada explains how to... Lees meer
Molecule made by muscle shown for first time to build bone
A recently identified molecule produced by skeletal muscle in response to exercise, has been shown to increase bone mass, according to a collaborative study between researchers at the Mount Sinai Bone Program, Icahn School... Lees meer
How hopping may help with osteoporosis risk in older people
"Older people could reduce risk of osteoporosis by hopping for two minutes a day," the Daily Mirror reports. A UK study found regular hopping increased bone density in older men. The study assigned more... Lees meer
Analysis of bone metabolism during early stage and clinical benefits of early intervention with alendronate in patients with systemic rheumatic diseases treated with high-dose glucocorticoid: Early DIagnosis and Treatment of OsteopoRosis in Japan (EDITOR-
Scientists, NASA astronauts developing near real-time osteoporosis, bone cancer test
A test in development offers the possibility of near real time monitoring of bone diseases, such as osteoporosis and multiple myeloma. The test, which measures changes in calcium isotope ratios, uses techniques from... Lees meer
Recommendations for an update of the 2010 European regulatory guideline on clinical investigation of medicinal products used in the treatment of osteoarthritis and reflections about related clinically relevant outcomes: expert consensus statement.
Osteoporosis Drug May Benefit the Frail Elderly in Nursing Homes
A single intravenous dose of the potent osteoporosis drug zoledronic acid significantly improved bone mineral density (BMD) in frail elderly women living in long-term care facilities. Positive findings from the... Lees meer
Further reductions in nonvertebral fracture rate with long-term denosumab treatment in the FREEDOM open-label extension and influence of hip bone mineral density after 3 years.
Osteoporos Int. 2015 Jun 12; Authors: Ferrari S, Adachi JD, Lippuner K, Zapalowski C, Miller PD, Reginster JY, Törring O, Kendler DL, Daizadeh NS, Wang A, O'Malley CD, Wagman RB, Libanati C, Lewiecki EM
Persistence, adherence, and medication-taking behavior in women with postmenopausal osteoporosis receiving denosumab in routine practice in Germany, Austria, Greece, and Belgium: 12-month results from a European non-interventional study.
Osteoporos Int. 2015 May 28; Authors: Hadji P, Papaioannou N, Gielen E, Feudjo Tepie M, Zhang E, Frieling I, Geusens P, Makras P, Resch H, Möller G, Kalouche-Khalil L, Fahrleitner-Pammer A
Hip fractures in the elderly caused by falls, not osteoporosis
Anti-osteoporotic medication is not an effective means for preventing hip fractures among the elderly, concludes a study recently published in the BMJ. According to Professor Teppo Järvinen from the University of... Lees meer
Human stem cells may improve bone healing in diabetics
Adding stem cells from human bone marrow to a broken diabetic bone enhances the repair process, increasing the strength of the newly formed bone, according to a laboratory-based study presented at the European Lees meer
Comparison between frailty index of deficit accumulation and fracture risk assessment tool (FRAX) in prediction of risk of fractures.
Bone. 2015 Apr 24; Authors: Li G, Thabane L, Papaioannou A, Adachi JD Abstract A frailty index (FI) of deficit accumulation could quantify and predict the risk of fractures based on the degree of frailty in the elderly. We... Lees meer
5-year follow-up of a randomized controlled trial of immediate versus delayed zoledronic acid for the prevention of bone loss in postmenopausal women with breast cancer starting letrozole after tamoxifen: N03CC (Alliance) trial.
The clinical use of vitamin D metabolites and their potential developments: a position statement from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) and the International Osteoporosis Foundation (IOF).
The use of bone densitometry in the USA in postmenopausal women between the ages of 50 and 64 years has decreased: from 149 per 1,000 person-years in 2009 to 110 per 1,000 person-years in 2012. These findings by Overman... Lees meer
Tooth extraction in patients receiving oral or intravenous bisphosphonate administration: a trigger for BRONJ development?
Conclusion: Tooth extraction in patients receiving bisphosphonates can be performed in a safe and predictable way, even in high-risk patients, when performed according to established guidelines. It is not tooth extractions... Lees meer
Hip fracture patients in long-term care are less likely to receive osteoporosis therapy
Canadian researchers calculated the proportion of high-risk residents of long-term care homes receiving osteoporosis medications and vitamin D supplementation according to specific high-risk categories. Marked undertreatment... Lees meer
Male smokers have a greater risk for osteoporosis than other men and even than women smokers, a recent study finds, suggesting that U.S. screening guidelines focused on women might need to be expanded to include men.
Associations between medication use and homocysteine levels in an older population, and potential mediation by vitamin B12 and folate: data from the B-PROOF Study.
Drugs Aging. 2014 Aug;31(8):611-21 Authors: Ham AC, Enneman AW, van Dijk SC, Oliai Araghi S, Swart KM, Sohl E, van Wijngaarden JP, van der Zwaluw NL, Brouwer-Brolsma EM, Dhonukshe-Rutten RA, van Schoor NM, van der Cammen TJ,... Lees meer
Changes in bone mineral density at 3 years in postmenopausal women receiving anastrozole and risedronate in the IBIS-II bone substudy: an international, double-blind, randomised, placebo-controlled trial.
Lancet Oncol. 2014 Dec;15(13):1460-8 Authors: Sestak I, Singh S, Cuzick J, Blake GM, Patel R, Gossiel F, Coleman R, Dowsett M, Forbes JF, Howell A, Eastell R
BACKGROUND: Aromatase inhibitors prevent breast... Lees meer
Compliance and persistence to oral bisphosphonate therapy following initiation within a secondary fracture prevention program: a randomised controlled trial of specialist vs. non-specialist management.
De dia's van de stemvragen van de Osteoporosedag der Lage Landen 2014 zijn nu beschikbaar op de website
De dia's van de stemvragen van de Lage Landen Meeting 2014 zijn nu beschikbaar op de website. De dia's zijn terug te vinden op de website onder: Seminars - Nascholingen 2006-2014 - Osteoporosedag der Lage Landen... Lees meer
Can We Identify Patients with High Risk of Osteoarthritis Progression Who Will Respond to Treatment? A Focus on Epidemiology and Phenotype of Osteoarthritis.
Drugs Aging. 2015 Feb 21; Authors: Bruyère O, Cooper C, Arden N, Branco J, Brandi ML, Herrero-Beaumont G, Berenbaum F, Dennison E, Devogelaer JP, Hochberg M, Kanis J, Laslop A, McAlindon T, Reiter S, Richette P,... Lees meer
A 7-year randomized, placebo-controlled trial assessing the long-term efficacy and safety of bazedoxifene in postmenopausal women with osteoporosis: effects on bone density and fracture.
Menopause. 2015 Feb 9; Authors: Palacios S, Silverman SL, de Villiers TJ, Levine AB, Goemaere S, Brown JP, De Cicco Nardone F, Williams R, Hines TL, Mirkin S, Chines AA, on behalf of the Bazedoxifene Study Group
Greater milk intake is associated with lower bone turnover, higher bone density, and higher bone microarchitecture index in a population of elderly Japanese men with relatively low dietary calcium intake: Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Stu
Osteoporos Int. 2015 Jan 28; Authors: Sato Y, Iki M, Fujita Y, Tamaki J, Kouda K, Yura A, Moon JS, Winzenrieth R, Iwaki H, Ishizuka R, Amano N, Tomioka K, Okamoto N, Kurumatani N
High prevalence of fragility vertebral fractures in patients hospitalised in Internal Medicine Units. Results of the POINT (Prevalence of Osteoporosis in INTernal medicine) study.
Bone. 2015 Jan 24;74C:114-120 Authors: Vitali C, Gussoni G, Bianchi G, Albanese CV, Diacinti D, Sinigaglia L, Nuti R, Muzzulini CL, Pintaudi C, Scanelli G, Magni G, Valerio A, Iori I, Mazzone A, Campanini M, for the Research... Lees meer
Efficacy of combined treatment with alendronate (ALN) and eldecalcitol, a new active vitamin D analog, compared to that of concomitant ALN, vitamin D plus calcium treatment in Japanese patients with primary osteoporosis.
Osteoporos Int. 2015 Jan 16; Authors: Sakai A, Ito M, Tomomitsu T, Tsurukami H, Ikeda S, Fukuda F, Mizunuma H, Inoue T, Saito H, Nakamura T, e-ADVANCED Study Group
INTRODUCTION: We compared the clinical efficacy... Lees meer
Potassium salts aid bone health, limit osteoporosis risk, new research finds
Helen Lambert, Lynda Frassetto, J. Bernadette Moore, David Torgerson, Richard Gannon , Peter Burckhardt and Susan Lanham-New. The effect of supplementation with alkaline potassium salts on... Lees meer
Bone loss drugs may help prevent endometrial cancer
Sharon Hensley Alford, Ramandeep Rattan, Thomas Buekers, and Adnan Munkarah. Protective effect of bisphosphonates on endometrial cancer incidence in the PLCO data. CANCER, December 2014 DOI: 10.1002/cncr.28952
Drug may help prevent bone fractures in patients on dialysis
S. M. Moe, S. Abdalla, G. M. Chertow, P. S. Parfrey, G. A. Block, R. Correa-Rotter, J. Floege, C. A. Herzog, G. M. London, K. W. Mahaffey, D. C. Wheeler, B. Dehmel, W. G. Goodman, T. B. Drueke. Effects of Cinacalcet on... Lees meer
Vertebral fractures on routine chest computed tomography: relation with arterial calcifications and future cardiovascular events
The International Journal of Cardiovascular Imaging 02 Dec 2014. Constantinus F. Buckens, Pim A. de Jong, Helena M. Verkooijen, Harald J. Verhaar, Willem P. Mali, Yolanda van der Graaf, PROVISIE study... Lees meer
Widely used osteoporosis drugs may prevent breast, lung and colon cancers
The most commonly used medications for osteoporosis worldwide, bisphosphonates, may also prevent certain kinds of lung, breast and colon cancers, according to two studies led by researchers at the Icahn School of Medicine at... Lees meer
Eli Lilly and Co. has bought the rights to develop an osteoporosis medicine that's delivered through a skin patch. The exclusive development agreement could lead to a notable advance in osteoporosis treatment if it... Lees meer
Prolonged risk of subtrochanteric and diaphyseal femur fractures after discontinuing alendronate treatment: A nationwide nested case-control study in Taiwan
Conclusion: Discontinuation of alendronate therapy did not reduce the risk of subtrochanteric femoral fractures until it was discontinued for >5 years. In conclusion, alendronate use significantly increased the risk... Lees meer
Diagnosis and Management of Osteonecrosis of the Jaw: A Systematic Review and International Consensus.
J Bone Miner Res. 2014 Nov 21; Authors: Khan A, Morrison A, Hanley D, Felsenberg D, McCauley L, O'Ryan F, Reid I, Ruggiero S, Taguchi A, Tetradis S, Watts N, Brandi M, Peters E, Guise T, Eastell R, Cheung A, Morin S,... Lees meer
Bone drug should be seen in a new light for its anti-cancer properties
Researchers have shown why calcium-binding drugs commonly used to treat people with osteoporosis, or with late-stage cancers that have spread to bone, may also benefit patients with tumors outside the skeleton, including... Lees meer
Baseline age and time to major fracture in younger postmenopausal women.
Menopause. 2014 Oct 27; Authors: Gourlay ML, Overman RA, Fine JP, Ensrud KE, Crandall CJ, Gass ML, Robbins J, Johnson KC, LeBlanc ES, Womack CR, Schousboe JT, LaCroix AZ, for the Women’s Health Initiative... Lees meer
Latest bone research abstracts ASBMR summarized in slides and videos
(International Osteoporosis Foundation) This educational slide deck highlights 60 original scientific abstracts presented at the Annual Meeting of the American Society for Bone and Mineral Research in September 2014.
Is There Enough Evidence to Use Bisphosphonates in HIV-Infected Patients? A Systematic Review and Meta-analysis.
In conclusion, administration of oral and intravenous bisphosphonates was associated with increased bone mineral density at the lumbar spine and total hip over two years in HIV-positive patients. However, none of the... Lees meer
When it Comes to Bone Health Males are the Weaker Sex
Alarming new data published today by the International Osteoporosis Foundation (IOF), shows that one-third of all hip fractures worldwide occur in men, with mortality rates as high as 37% in the first year following... Lees meer
'Unsung' cells double the benefits of a new osteoporosis drug
Experiments in mice with a bone disorder similar to that in women after menopause show that a scientifically overlooked group of cells are likely crucial to the process of bone loss caused by the disorder, according to Johns... Lees meer
Switch patterns of osteoporosis medication and its impact on persistence among postmenopausal women in the UK General Practice Research Database
Conclusion: Among women who switch their initial medication, even though switching to the second medication improves persistence during the initial therapy, persistence on the second and subsequent therapies remains... Lees meer
Effect of Oral Bisphosphonates for Osteoporosis on Development of Skeletal Metastases in Women With Breast Cancer: Results From a Pharmaco-epidemiological Study
Conclusion: Low-dose oral bisphosphonates administered for prevention or treatment of postmenopausal osteoporosis were associated with lower risk of skeletal metastasis in patients with early- or more advanced-stage breast... Lees meer
Predictors of re-fracture amongst patients managed within a secondary fracture prevention program: a 7-year prospective study
Conclusions: Amongst patients managed within a dedicated SFP programme, poor compliance, multiple co-morbidities, corticosteroid therapy, low hip BMD or low body weight are all associated with increased risk of re-fracture.... Lees meer
Distribution of vertebral fractures varies among patients according to hip fracture type
Conclusion: The distribution of vertebral fractures among patients with subcapital fractures differed from the other fracture groups, which may indicate that subcapital fractures and some lumbar fractures have a different... Lees meer
Ulnar fractures with bisphosphonate therapy: a systematic review of published case reports
Conclusion: Ulnar fractures in patients with bisphosphonate therapy demonstrate features similar to those described for atypical femoral fractures, suggesting that these fractures could also possibly be due to... Lees meer
Merck Announces Data from Pivotal Phase 3 Fracture Outcomes Study for Odanacatib, an Investigational Oral, Once-Weekly Treatment for Osteoporosis
Merck, known as MSD outside the United States and Canada, today announced data from the pivotal Phase 3 fracture outcomes study for odanacatib in postmenopausal women with osteoporosis. Odanacatib is Merck’s... Lees meer
Postmenopausal women with osteoporosis treated with an oral calcium-sensing receptor antagonist showed increases in bone formation markers but it failed to boost bone mineral density (BMD) in a phase II dose-ranging study.... Lees meer
National Osteoporosis Society Vitamin D Guideline Summary
The National Osteoporosis Society (NOS) published its document, Vitamin D and Bone Health: A Practical Clinical Guideline for Patient Management, in 2013 as a practical clinical guideline on the management of vitamin D... Lees meer
Increasing rates of pelvic fractures among older adults: The Netherlands, 1986-2011
Conclusion: absolute numbers and incidence rates of pelvic fractures are increasing among the older Dutch population. Considering the fact the general population is growing older, an increasing number of elderly suffer from... Lees meer
The role of dietary protein and vitamin D in maintaining musculoskeletal health in postmenopausal women: A consensus statement from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO).
Maturitas. 2014 Jul 17; Authors: Rizzoli R, Stevenson JC, Bauer JM, van Loon LJ, Walrand S, Kanis JA, Cooper C, Brandi ML, Diez-Perez A, Reginster JY, for the ESCEO Task Force
Risk factors for the second contralateral hip fracture in elderly patients: a systematic review and meta-analysis.
CONCLUSIONS: Patients involved with female, living in institutions, osteoporosis, low vision, dizziness, dementia, respiration diseases and cardiac diseases were at risk for a second contralateral hip fracture after the... Lees meer
Failure in the application of fragility fracture prevention guidelines.
CONCLUSIONS: In conjunction with NICE and NOGG recommendations, FRAX(®) was able to identify 80% of our fracture population as intermediate or high risk on the day of fracture. Correct management was evident in a third... Lees meer
Does long-distance training saddle young cyclists with fragile bones?
Young cyclists training to join the Tour de France could be causing irreversible damage.The combination of cycling extreme distances and restricting caloric intake to reduce weight can decrease bone density to levels that... Lees meer
MicroRNA that blocks bone destruction could offer new therapeutic target for osteoporosis
UT Southwestern cancer researchers have identified a promising molecule that blocks bone destruction and, therefore, could provide a potential therapeutic target for osteoporosis and bone metastases of cancer...
Time Course of Bone Mineral Density Changes With Denosumab Compared With Other Drugs in Postmenopausal Osteoporosis: A Dose-response Based Meta-analysis.
Conclusion: This exploratory analysis shows that 3 years of treatment with denosumab resulted in bigger changes in LS and TH BMD compared with 3 years of treatment with 10 mg/day oral alendronate, 5 mg/year iv zoledronic... Lees meer
The Combination of Vitamin D Deficiency and Mild to Moderate Chronic Kidney Disease Is Associated With Low Bone Mineral Density and Deteriorated Femoral Microarchitecture: Results From the KNHANES 2008-2011.
J Clin Endocrinol Metab. 2014 May 30;:jc20133764 Authors: Lee YH, Kim JE, Roh YH, Choi HR, Rhee Y, Kang DR, Lim S
Context: Although mild to moderate chronic kidney disease (CKD) and vitamin D deficiency are... Lees meer
Calcium supplements not associated with increased risk of cardiovascular disease in women
Calcium supplements are widely taken by women for bone health. Previous studies have suggested that calcium supplements may increase risk of cardiovascular disease, but the data has been inconsistent. A new study did not... Lees meer
Osteoporosis drugs appear to impede cell membrane repair
A class of drugs widely used to treat osteoporosis appears to impede a cell's ability to repair a protective outer membrane that helps determine what enters and exits, researchers report. The inability to quickly repair... Lees meer
In April 2013, IOF officially launched the Capture the Fracture programme, a multi-stakeholder campaign to prevent secondary fractures due to osteoporosis through the implementation of Fracture Liaison Services (FLS)... Lees meer
Pharmacists Can Use FRAX to Identify Osteoporosis Risk
The pharmacist can help prevent osteoporosis from occurring and, in those who already have the condition, help minimale risk for fracture, according to a presentation at the American Pharmacists Association (APhA) 2014... Lees meer
Providing evidence-based solutions Three groundbreaking new reports published by IOF in 2013 reveal the burden of osteoporosis in Europe and the Asia-Pacific. The reports are being used by national osteoporosis societies as... Lees meer
Long-term risk of medical conditions associated with breast cancer treatment.
Breast Cancer Res Treat. 2014 Apr 3; Authors: Hill DA, Horick NK, Isaacs C, Domchek SM, Tomlinson GE, Lowery JT, Kinney AY, Berg JS, Edwards KL, Moorman PG, Plon SE, Strong LC, Ziogas A, Griffin CA, Kasten CH, Finkelstein... Lees meer
The global burden attributable to low bone mineral density.
Ann Rheum Dis. 2014 Apr 1; Authors: Sànchez-Riera L, Carnahan E, Vos T, Veerman L, Norman R, Lim SS, Hoy D, Smith E, Wilson N, Nolla JM, Chen JS, Macara M, Kamalaraj N, Li Y, Kok C, Santos-Hernández C, March... Lees meer
Economic evaluation of an osteoporosis screening campaign using FRAX
In new research presented at the World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases today, investigators showed that an osteoporosis screening strategy using FRAX as a pre-screening tool is... Lees meer
New FRAX app launched by the International Osteoporosis Foundation
Osteoporosis management guidelines around the world now recommend that fracture risk assessment be part of any clinical evaluation for osteoporosis. As a result, rather than relying on bone mineral density values alone,... Lees meer
Age discrimination in osteoporosis screening—Data from the Aalborg University Hospital Record for Osteoporosis Risk Assessment (AURORA)
We report data from the 8,131 consecutive evaluations in 7914 individuals at the Osteoporosis Clinic from January 1st 2010 through December 31st 2012.Results: Risk factor data were available in >96% and DXA in 98%.... Lees meer
Melk drinken tijdens tienerjaren helpt niet om osteoporose te voorkomen
Vaak wordt aangeraden om tijdens de kinder- en tienerjaren veel melk te drinken, om op die manier voldoende botmassa op te bouwen en op latere leeftijd botontkalking (osteoporose) te voorkomen. Een nieuw Amerikaans onderzoek... Lees meer
Early Changes in Bone Density, Micro-Architecture, Bone Resorption and Inflammation Predict the Clinical Outcome 12 Weeks After Conservatively Treated Distal Radius Fractures: An Exploratory Study.
Fracture healing is an active process with early changes in bone and inflammation. We performed an exploratory study evaluating the association between early changes in densitometric, structural, biomechanical and... Lees meer
Effects of Odanacatib on the Radius and Tibia of Postmenopausal Women: Improvements in Bone Geometry, Microarchitecture and Estimated Bone Strength.
The cathepsin K inhibitor odanacatib, currently in phase 3 development for postmenopausal osteoporosis, has a novel mechanism of action that reduces bone resorption while maintaining bone formation. In phase 2 studies,... Lees meer
Biochemical Markers of Bone Turnover in Chronic Obstructive Pulmonary Disease (COPD).
Osteoporosis has a higher prevalence in COPD patients and its etiology is very complex, it has been linked with reduced physical activity, low body mass index (BMD), a worse degree of airflow limitation and... Lees meer
The effects of bazedoxifene in the ovariectomized aged cynomolgus monkey.
Bazedoxifene (BZA) is a novel selective estrogen receptor modulator in clinical development for the prevention and treatment of postmenopausal osteoporosis. This preclinical study evaluated the efficacy and safety of BZA in... Lees meer
Evaluation of the anti-osteoporotic effects of metformin and sitagliptin in postmenopausal diabetic women.
Osteoporosis is the most important metabolic bone disease in patients with diabetes mellitus. Several studies have documented that metformin is osteogenic in vitro. In contrast, others showed no effect of metformin on the... Lees meer
Interrelationship among muscle, fat, and bone: Connecting the dots on cellular, hormonal, and whole body levels.
While sarcopenia and sarcopenic obesity have been recognized in the last decade, a combined concept to include decreased muscle mass and strength, as well as decreased bone mass with coexistence of adiposity is discussed... Lees meer
The association between plasma homocysteine levels and bone quality and bone mineral density parameters in older persons.
INTRODUCTION: High plasma homocysteine levels have been associated with incident osteoporotic fractures, but the mechanisms underlying this association are still unknown. It has been hypothesized that homocysteine might... Lees meer
Clinical treatment outcomes for 40 patients with bisphosphonates-related osteonecrosis of the jaws.
BACKGROUND/PURPOSE: Bisphosphonates (BPs) are used to treat osteoporosis and bone metastases from malignancy. They may result in BPs-related osteonecrosis of the jaws (BRONJ) in a subset of patients receiving BPs. This study... Lees meer
Serum periostin is associated with fracture risk in postmenopausal women: a 7 years prospective analysis of the OFELY study.
Purpose: Periostin (POSTN) is a secreted gamma-carboxyglutamic acid-containing protein (Gla protein) expressed mainly in the periosteum in adult individuals. POSNT deficient mice develop periodontis and osteoporosis with... Lees meer
National Bone Health Alliance Clinical Diagnosis of Osteoporosis Working ...
The National Bone Health Alliance (NBHA) Clinical Diagnosis of Osteoporosis Working Group recommends expanding the criteria for making a diagnosis of osteoporosis to include all post-menopausal women and all men age 50 en... Lees meer
Bone mass behavior after 1 year of different treatment strategies in prostate cancer patients subjected to androgen deprivation therapy.
The aim of this study was to evaluate bone mass changes after 1 year of four different types of pharmacological intervention. Ninety-seven prostate cancer patients treated with androgen deprivation therapy, and severe... Lees meer
Choice of Lumbar Spine Bone Density Reference Database for Fracture Prediction in Men and Women: A Population-Based Analysis.
The diagnosis of osteoporosis in men is controversial, although most studies demonstrate similar fracture rates for men and women with the same level of hip bone mineral density (BMD). Whether this applies to the lumbar... Lees meer
Fracture incidence after 3 years of aromatase inhibitor therapy.
BACKGROUND: The purpose of this study was to describe the fracture incidence and bone mineral density (BMD) evolution in a large cohort of post-menopausal women with breast cancer after 3 years of aromatase inhibitor (AI)... Lees meer
Mortality following the first hip fracture in Norwegian women and men 1999-2008. A NOREPOS study.
Hip fractures are associated with increased mortality and their incidence in Norway is one of the highest worldwide. The aim of this nationwide study was to examine short and long term mortality after hip fractures, burden... Lees meer
Anti-osteoporotic drugs and vascular calcification: the bidirectional calcium traffic.
During the last years, numerous epidemiological studies have demonstrated a direct relationship between vascular calcification and low bone mineral density. This observation is in line with experimental data demonstrating... Lees meer
Plasma level of homocysteine associated with severe vertebral fracture in postmenopausal women.
The aim of this cross-sectional cohort study was to clarify risk factors for severe vertebral fractures in postmenopausal Japanese women. Subjects were ambulatory volunteers age over 50 years who were recruited from a... Lees meer
Overlapping and Continued Alendronate or Raloxifene Administration in Patients on Teriparatide: Effects on Areal and Volumetric Bone Mineral Density The CONFORS Study.
Nine month teriparatide (TPTD) monotherapy followed by co-administration of raloxifene (RAL) or alendronate (ALN) for another nine months resulted in incremental bone mineral density (BMD) increase. The aim of this study was... Lees meer
FRAX without Bone Mineral Density Versus Osteoporosis Self-Assessment Screening Tool as Predictors of Osteoporosis in Primary Screening of Individuals Aged 70 and Older.
To compare two well-validated tools-the FRAX without bone mineral density (BMD) and the Osteoporosis Self-Assessment Screening Tool (OST)-in predicting osteoporosis and to define thresholds above and below which it would be... Lees meer
Sclerostin and bone strength in women in their 10th decade of life.
Sclerostin is a potent inhibitor of bone formation but has been shown to correlate positively with areal bone mineral density (aBMD). Little is known about its relationship to parameters of bone strength and volumetric BMD... Lees meer
Sharper view gained of osteoporosis development: Intracellular protein discovered
In the bones supporting our bodies, calcium regulation occurs by balancing the activities of osteoclasts, which are groups of cells that increase the calcium concentration in blood by destroying bone tissue, and osteoblasts,... Lees meer
Predicting fracture risk for treated, untreated patients
A new study summarizes the clinical performance of serum procollagen type I N propeptide and serum C-terminal cross-linking telopeptide of type I collagen in fracture risk prediction in untreated individuals in prospective... Lees meer
PINP as a biological response marker during teriparatide treatment for osteoporosis.
Postmenopausal women with severe osteoporosis may require treatment with the bone anabolic drug teriparatide. While changes in bone mineral density (BMD) are one measure of response, BMD changes often require a minimum of... Lees meer
Prevalence of vertebral fractures and minor vertebral deformities evaluated by DXA-assisted vertebral fracture assessment (VFA) in a population-based study of postmenopausal women: the FRODOS study.
Population-based studies performed with vertebral fracture assessment (VFA) morphometric technology are lacking in postmenopausal osteoporosis. In this study, we show a lower than expected prevalence of vertebral... Lees meer
Fractures in patients aged ≥ 65 years constitute an increasing burden on health and social care and are associated with a high morbidity and mortality. There is little accurate information about the epidemiology of... Lees meer
Delayed/non‐union of upper limb fractures with bisphosphonates: systematic review and recommendations
Differences in union time between BP users and non‐users are not significant enough to change current practice patterns and do not outweigh the benefits of BP therapy. There is no evidence to encourage early surgical... Lees meer
Two Years of Denosumab and Teriparatide Administration in Postmenopausal Women with Osteoporosis (The DATA Extension Study): a Randomized Controlled Trial
Two years of concomitant teriparatide and denosumab therapy increases BMD more than either medication alone and more than has been reported with any current therapy. The combination of these agents may prove to be an... Lees meer
Antidepressant use and 10-year incident fracture risk: the population-based Canadian Multicentre Osteoporosis Study (CaMoS)
We used data from a large, prospective Canadian cohort to assess the association between selective serotonin reuptake inhibitors (SSRIs) and serotonin and noradrenaline reuptake inhibitors (SNRIs) and fracture. We found an... Lees meer
Fracture liaison service: impact on subsequent nonvertebral fracture incidence and mortality.
CONCLUSIONS: Patients seen at the fracture liaison service had a significantly lower mortality and subsequently a lower risk of nonvertebral fracture than those not seen at the fracture liaison service, with a reduction of... Lees meer
Rates of osteoporosis treatment after hip fracture on the decline
The majority of patients with hip fracture do not receive osteoporosis treatment and the rates of treatment have been declining, a finding that is not consistent with osteoporosis treatment guidelines endorsed by the... Lees meer
Conventional assessment strategies identify more postmenopausal women with ...
The U.S. Preventative Service Task Force recommendation of osteoporosis screening for women younger than 65 years was moderately better than chance alone, but inferior to conventional strategies, according to results of a... Lees meer
Patient Perceptions of Osteoporosis Treatment Thresholds.
There is substantial variability in preferences for postmenopausal osteoporosis treatment. Presentation of individualized fracture risks as recommended by current guidelines has potential to allow better targeting to... Lees meer
Finding could lead to new treatments for osteoporosis
Scientists at Washington University School of Medicine in St. Louis have discovered what appears to be a potent stimulator of new bone growth. The finding could lead to new treatments for osteoporosis and other diseases that... Lees meer
Osteoporosis screening recommendations may miss two-thirds of women aged
Using health data on women ages 50–64 from the Women's Health Initiative study, the researchers found that the current strategy would identify only 34 percent of women who actually had bone-mineral density in the... Lees meer
Scientists develop automated system that identifies high-risk osteoporosis ...
An automated system that identifies high-risk osteoporosis patients being treated for fractures and can generate letters encouraging follow-up is an effective way to promote osteoporosis intervention and prevent future... Lees meer
Doctors commonly recommend drug holidays, or breaks, from certain osteoporosis drugs due to the risks associated with these treatments. Yet little has been known about the ideal duration of... Lees meer
Changes in Bone Mineral Density After Parathyroidectomy in Elderly Patients With Primary Hyperparathyroidism
In the United States, approximately 1.5 million fractures occur due to osteoporosis annually; over 1/3 are due to low-impact falls among the community-dwelling elderly. Primary hyperparathyroidism (pHPT), by increasing... Lees meer
Rheumatoid arthritis and incident fracture in women: a case-control study
Given that women with RA have a greater risk of fracture compared to women without RA, these patients may be a suitable target population for anti-resorptive agents; however, larger studies are warranted. (Source: BMC... Lees meer