• Stichting IWO wordt bestuurd door artsen die werkzaam zijn in verschillende organisaties en specialismen, maar hetzelfde doel voor ogen hebben

  • Stichting IWO wordt bestuurd door artsen die werkzaam zijn in verschillende organisaties en specialismen, maar hetzelfde doel voor ogen hebben

Nieuws

Volg hier relevant internationaal nieuws over osteoporose. De nieuwsfeed bevat zowel doorgeplaatste artikelen, als publicaties uit de Osteoporose journalen. Klik hier voor rss-feeds.

 

  • Does bisphosphonate-based anti-osteoporosis medication affect osteoporotic spinal fracture healing?

    Osteoporos Int. 2015 Jul 23; Authors: Ha KY, Park KS, Kim SI, Kim YH

    INTRODUCTION: The purpose of this prospective study is to investigate whether bisphosphonate-based anti-osteoporosis medication affects fracture... Lees meer

    Gepost op 27 July 2015

    Bron: http://www.ncbi.nlm.nih.gov....

  • The effect of 8 or 5 years of denosumab treatment in postmenopausal women with osteoporosis: results from the FREEDOM Extension study.

    Osteoporos Int. 2015 Jul 23; Authors: Papapoulos S, Lippuner K, Roux C, Lin CJ, Kendler DL, Lewiecki EM, Brandi ML, Czerwiński E, Franek E, Lakatos P, Mautalen C, Minisola S, Reginster JY, Jensen S, Daizadeh NS, Wang A,... Lees meer

    Gepost op 27 July 2015

    Bron: http://www.ncbi.nlm.nih.gov....

  • Use of Teriparatide to improve fracture healing: What is the evidence?

    World J Orthop. 2015 Jul 18;6(6):457-61 Authors: Babu S, Sandiford NA, Vrahas M

    Teriparatide is a recombinant form of the biologically active component of Parathyroid hormone. It has been shown to increase bone... Lees meer

    Gepost op 21 July 2015

    Bron: http://www.ncbi.nlm.nih.gov....

  • Recommendations for an update of the 2010 European regulatory guideline on clinical investigation of medicinal products used in the treatment of osteoarthritis and reflections about related clinically relevant outcomes: expert consensus statement.

    Osteoarthritis Cartilage. 2015 Jul 14; Authors: Reginster JY, Reiter-Niesert S, Bruyère O, Berenbaum F, Brandi ML, Branco J, Devogelaer JP, Herrero-Beaumont G, Kanis J, Maggi S, Maheu E, Richette P, Rizzoli R, Cooper... Lees meer

    Gepost op 21 July 2015

    Bron: http://www.ncbi.nlm.nih.gov....

  • Additive effect of elcatonin to risedronate for chronic back pain and quality of life in postmenopausal women with osteoporosis: a randomized controlled trial

    J Bone Miner Metab 33(4);432-439:2015. Michio Hongo, Naohisa Miyakoshi, Yuji Kasukawa, Yoshinori Ishikawa, Yoichi Shimada. 

    • Vitamin k antagonists use and fracture risk: results from a systematic review and meta-analysis.

      J Thrombosis and Haemostasis 2015. Veronese B, Bano G, Bertozzo G, Granziera S, Solmi M, Manzato E, Sergi G, Cohen AT, Correll CU.

      Lees meer

      Gepost op 21 July 2015

      Bron: http://www.medworm.com/inde....

    • Incidence and Predictors of Multiple Fractures Despite High Adherence to Oral Bisphosphonates: A Binational Population‐Based Cohort Study

      J Bone Miner Res 2015; juli14. Hawley SLees meer

      Gepost op 17 July 2015

      Bron: http://www.medworm.com/inde....

    • Choice of osteoporosis guideline has important implications for the treatment decision in elderly women referred to a fall clinic.

      Dan Med J. 2014. Thomsen K, Ryg J, Matzen L, Hermann AP, Masud T. ... Lees meer

      Gepost op 17 July 2015

      Bron: http://www.medworm.com/inde....

    • Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus.

      J Bone Miner Res. 2015 Jan;30(1):3-23. Khan AA, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O'Ryan F, Reid IR, Ruggiero SL, Taguchi A, Tetradis S, Watts NB, Brandi ML, Peters E, Guise T, Eastell R, Cheung AM,... Lees meer

      Gepost op 17 July 2015

      Bron: http://www.medworm.com/inde....

    • Subgroup variations in bone mineral density response to zoledronic acid after hip fracture.

      J Bone Miner Res. 2014 Dec;29(12):2545-51. Magaziner JS, Orwig DL, Lyles KW, Nordsletten L, Boonen S, Adachi JD, Recknor C, Colón-Emeric CS, Mesenbrink P, Bucci-Rechtweg C, Su G, Johnson R, Pieper CF.

      ... Lees meer

      Gepost op 17 July 2015

      Bron: http://www.medworm.com/inde....

    • Comparative effects of teriparatide, denosumab, and combination therapy on peripheral compartmental bone density, microarchitecture, and estimated strength: the DATA-HRpQCT Study.

      J Bone Miner Res. 2015 Jan;30(1):39-45. Tsai JN, Uihlein AV, Burnett-Bowie SA, Neer RM, Zhu Y, Derrico N, Lee H, Bouxsein ML, Leder BZ.

      Lees meer

      Gepost op 17 July 2015

      Bron: http://www.medworm.com/inde....

    • Vitamin k antagonists use and fracture risk: results from a systematic review and meta‐analysis

      J Thromb Haemos 2015; jul 14. Veronese N, Bano G, Bertozzo G, Granziera S, Solmi M,... Lees meer

      Gepost op 17 July 2015

      Bron: http://www.medworm.com/inde....

    • Urinary Tract Stones and Osteoporosis: Findings From the Women's Health Initiative

      J Bone Miner Res. 2015; jul 14. Laura D Carbone, Kathleen M Hovey, Christopher A Andrews, Fridtjof Thomas, Mathew D Sorensen, Carolyn J Crandall, Nelson B Watts, Monique Bethel andKaren C Johnson

      Kidney... Lees meer

      Gepost op 17 July 2015

      Bron: http://www.medworm.com/inde....

    • Calcium supplements: benefits and risks

      J Intern Med. 2015; jul 14. Reid IR, Bristow SM, Bolland MJ. 

      Calcium is an essential... Lees meer

      Gepost op 17 July 2015

      Bron: http://www.medworm.com/inde....

    • Associations between calcium and vitamin D supplement use as well as their serum concentrations and subclinical cardiovascular disease phenotypes.

      Atherosclerosis. 2015 Jun 19;241(2):743-751. Thiele I, Lees meer

      Gepost op 09 July 2015

      Bron: http://www.medworm.com/inde....

    • Denosumab and teriparatide transitions in postmenopausal osteoporosis (the DATA-Switch study): extension of a randomised controlled trial.

      Lancet. 2015 Jul 2. [Epub ahead of print] Leder BZ, Tsai JN, Uihlein AV, Wallace PM, Lee H, Neer RM, Burnett-Bowie SM 

      Lees meer

      Gepost op 09 July 2015

      Bron: http://www.medworm.com/inde....

    • Use of osteoporosis medications after hospitalization for hip fracture: a cross-national study.

      Am J Med. 2015 May;128(5):519-26.e1. Kim SC, Lees meer

      Gepost op 09 July 2015

      Bron: http://www.medworm.com/inde....

    • Bone fracture and the interaction between bisphosphonates and proton pump inhibitors: a meta-analysis.

      Int J Clin Exp Med. 2015 Apr 15;8(4):4899-910. eCollection 2015. Lees meer

      Gepost op 09 July 2015

      Bron: http://www.medworm.com/inde....

    • Rationale and design of MUSIC OS-EU: an international observational study of the treatment of postmenopausalwomen for osteoporosis in Europe and Canada.

      Clin Exp Rheumatol 2015 Jul 6. [Epub ahead of print] Modi A, Sen S, Adachi JD, Adami S, Cortet B, Cooper AL, Geusens P,... Lees meer

      Gepost op 09 July 2015

      Bron: http://www.medworm.com/inde....

    • Atypical Femoral Fractures-Ongoing and History of Bone-Specific Therapy, Concomitant Diseases, Medications, and Survival.

      J Clin Densitom. 2015 Jun 23; Authors: Muschitz C, Thaler HW, Dimai HP, Resch H, Kocijan R, Kostic M, Geiger C, Kaider A, Muschitz GK, Szivak M, Pietschmann P

      Although atypical femoral fractures (AFFs) are... Lees meer

      Gepost op 28 June 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Pregnancy and Lactation-Associated Osteoporosis: Bone Histomorphometric Analysis and Response to Treatment with Zoledronic Acid.

      Calcif Tissue Int. 2015 Jun 25; Authors: Grizzo FM, da Silva Martins J, Pinheiro MM, Jorgetti V, Carvalho MD, Pelloso SM

      Pregnancy and lactation-associated osteoporosis (PAO) is a rare condition with little known... Lees meer

      Gepost op 28 June 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Physical Activity, Bone Health, and Obesity in Peri-/Pre- and Postmenopausal Women: Results from the EPIC-Potsdam Study.

      Calcif Tissue Int. 2015 Jun 25; Authors: Menzel J, di Giuseppe R, Wientzek A, Kroke A, Boeing H, Weikert C

      Physical activity (PA) is suggested to increase the peak bone mass and to minimize age-related bone loss,... Lees meer

      Gepost op 28 June 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Spinal Bone Texture Assessed by Trabecular Bone Score (TBS) in Adolescent Girls with Anorexia Nervosa.

      J Clin Endocrinol Metab. 2015 Jun 24;:jc20152002 Authors: Donaldson AA, Feldman HA, O'Donnell JM, Gopalakrishnan G, Gordon CM

      CONTEXT: Trabecular bone score (TBS) is a bone assessment tool that offers... Lees meer

      Gepost op 28 June 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Extracting accurate strain measurements in bone mechanics: A critical review of current methods.

      J Mech Behav Biomed Mater. 2015 Jun 11;50:43-54 Authors: Grassi L, Isaksson H 

      Osteoporosis related fractures are a social burden that advocates for more accurate fracture prediction methods. Mechanistic... Lees meer

      Gepost op 24 June 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Bone Geometry, Volumetric Density, Microarchitecture and Estimated Bone Strength Assessed by HR-pQCT in Adult Patients with Type 1 Diabetes Mellitus.

      J Bone Miner Res. 2015 Jun 10; Authors: Shanbhogue VV, Hansen S, Frost M, Jørgensen NR, Hermann AP, Henriksen JE, Brixen K 

      The primary goal of this cross-sectional in vivo study was to assess... Lees meer

      Gepost op 24 June 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Pharmacologic Options for the Treatment of Sarcopenia.

      Calcif Tissue Int. 2015 Jun 23; Authors: Morley JE 

      Sarcopenia is now clinically defined as a loss of muscle mass coupled with functional deterioration (either walking speed or distance or grip strength).... Lees meer

      Gepost op 24 June 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • The calcium-sensing receptor in bone metabolism: from bench to bedside and back.

      Osteoporos Int. 2015 Jun 23; Authors: Cianferotti L, Gomes AR, Fabbri S, Tanini A, Brandi ML 

      INTRODUCTION: The calcium-sensing receptor (CaSR) is a key player in the maintenance of calcium homeostasis through... Lees meer

      Gepost op 24 June 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Osteoporosis Drug May Benefit the Frail Elderly in Nursing Homes

      A single intravenous dose of the potent osteoporosis drug zoledronic acid significantly improved bone mineral density (BMD) in frail elderly women living in long-term care facilities. Positive findings from the... Lees meer

      Gepost op 24 June 2015

      Bron: http://www.medworm.com/inde....

    • Hyponatremia is Associated with Increased Osteoporosis and Bone Fractures in a Large U. S. Health System Population.

      J Clin Endocrinol Metab. 2015 Jun 17;:jc20151261 Authors: Miriam Rachel Usala G, Fernandez SJ, Mete M, Cowen L, Shara NM, Barsony J, Verbalis JG

      CONTEXT: The significance of studies suggesting an increased risk of... Lees meer

      Gepost op 21 June 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Oral Bisphosphonate and Risk of Esophageal Cancer: A Nationwide Claim Study.

      J Bone Metab. 2015 May;22(2):77-81 Authors: Seo GH, Choi HJ 

      BACKGROUND: Epidemiology studies suggest that oral bisphosphonate may increase the risk of esophageal cancer. The present study aimed to investigate... Lees meer

      Gepost op 21 June 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • NELL-1 in the treatment of osteoporotic bone loss.

      Nat Commun. 2015;6:7362 Authors: James AW, Shen J, Zhang X, Asatrian G, Goyal R, Kwak JH, Jiang L, Bengs B, Culiat CT, Turner AS, Seim Iii HB, Wu BM, Lyons K, Adams JS, Ting K, Soo C 

      NELL-1 is a secreted,... Lees meer

      Gepost op 21 June 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Efficacy of weekly teriparatide does not vary by baseline fracture probability calculated using FRAX.

      Osteoporos Int. 2015 Jun 20; Authors: Harvey NC, Kanis JA, Odén A, Nakamura T, Shiraki M, Sugimoto T, Kuroda T, Johansson H, McCloskey EV

      INTRODUCTION: Previous studies have suggested that the efficacy of... Lees meer

      Gepost op 21 June 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Drug approved to treat osteoporosis shows promise in pre-clinical diabetes research

      Lees meer

      Gepost op 21 June 2015

      Bron: http://www.medworm.com/inde....

    • Fracture risk in patients with newly diagnosed type 2 diabetes: a retrospective database analysis in primary care.

      J Diabetes Complications. 2015 May 16; Authors: Rathmann W, Kostev K 

      AIMS: It is unclear whether fracture risk is increased in newly diagnosed type 2 diabetes patients. In addition, fracture risk of various... Lees meer

      Gepost op 17 June 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Effective secondary fracture prevention: implementation of a global benchmarking of clinical quality using the IOF Capture the Fracture® Best Practice Framework tool.

      Osteoporos Int. 2015 Jun 13; Authors: Javaid MK, Kyer C, Mitchell PJ, Chana J, Moss C, Edwards MH, McLellan AR, Stenmark J, Pierroz DD, Schneider MC, Kanis JA, Akesson K, Cooper C, IOF Fracture Working Group, EXCO

      ... Lees meer

      Gepost op 14 June 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Treatment with intermittent PTH increases Wnt10b production by T cells in osteoporotic patients.

      Osteoporos Int. 2015 Jun 12; Authors: D'Amelio P, Sassi F, Buondonno I, Fornelli G, Spertino E, D'Amico L, Marchetti M, Lucchiari M, Roato I, Isaia GC

      INTRODUCTION: The aim of this study is to assess the... Lees meer

      Gepost op 14 June 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Further reductions in nonvertebral fracture rate with long-term denosumab treatment in the FREEDOM open-label extension and influence of hip bone mineral density after 3 years.

      Osteoporos Int. 2015 Jun 12; Authors: Ferrari S, Adachi JD, Lippuner K, Zapalowski C, Miller PD, Reginster JY, Törring O, Kendler DL, Daizadeh NS, Wang A, O'Malley CD, Wagman RB, Libanati C, Lewiecki EM

      ... Lees meer

      Gepost op 14 June 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Bone cross-sectional geometry is not associated with atypical femoral fractures in Asian female chronic bisphosphonate users.

      Bone. 2015 Jun 8; Authors: Chou AC, Ng AC, Png MA, Chua DT, Ng DC, Howe TS, Koh JS 

      INTRODUCTION: Atypical femoral fractures (AFF) tend to occur in Asian women with prolonged bisphosphonate exposure. Hip... Lees meer

      Gepost op 14 June 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • The Association between Metabolic Syndrome, Bone Mineral Density, Hip Bone Geometry and Fracture Risk: The Rotterdam Study.

      PLoS One. 2015;10(6):e0129116 Authors: Muka T, Trajanoska K, Kiefte-de Jong JC, Oei L, Uitterlinden AG, Hofman A, Dehghan A, Zillikens MC, Franco OH, Rivadeneira F

      The association between metabolic syndrome (MS)... Lees meer

      Gepost op 14 June 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Potential new treatment for osteoporosis

      Scientists have identified a new therapeutic approach that, while still preliminary, could promote the development of new bone-forming cells in patients suffering from bone loss.

      Lees meer

      Gepost op 14 June 2015

      Bron: http://www.medworm.com/inde....

    • Different reference BMDs affect the prevalence of osteoporosis.

      J Bone Miner Metab. 2015 Jun 10; Authors: Jung KJ, Chung CY, Park MS, Kwon SS, Moon SY, Lee IH, Kim KH, Lee KM

      The T score represents the degree of deviation from the peak bone mineral density (BMD) (reference... Lees meer

      Gepost op 12 June 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Bone health in living kidney donors.

      Curr Opin Urol. 2014 Nov;24(6):624-8 Authors: Naylor KL, Garg AX 

      PURPOSE OF REVIEW: Living kidney donors may experience changes in bone mineral metabolism, which adversely affect the skeletal system. In this... Lees meer

      Gepost op 10 June 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • The potential use of antisclerostin therapy in chronic kidney disease - mineral and bone disorder.

      Curr Opin Nephrol Hypertens. 2015 Jul;24(4):324-9 Authors: Costa AG, Bilezikian JP, Lewiecki EM 

      PURPOSE OF REVIEW: Sclerostin is a regulator of the osteoanabolic canonical Wnt signaling pathway, and thus... Lees meer

      Gepost op 10 June 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Modulating Bone Resorption and Bone Formation in Opposite Directions in the Treatment of Postmenopausal Osteoporosis.

      Drugs. 2015 Jun 9; Authors: Appelman-Dijkstra NM, Papapoulos SE 

      Bone remodeling, the fundamental process for bone renewal, is targeted by treatments of osteoporosis to correct the imbalance between bone... Lees meer

      Gepost op 10 June 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Chlamydia pneumoniae and Helicobacter pylori IgG seropositivities are not predictors of osteoporosis-associated bone loss: a prospective cohort study.

      J Bone Miner Metab. 2015 Jun 9; Authors: Kalantarhormozi MR, Assadi M, Vahdat K, Asadipooya K, Ostovar A, Raissi K, Darabi H, Farrokhi S, Dobaradaran S, Farrokhnia M, Nabipour I 

      The potential link between... Lees meer

      Gepost op 10 June 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Bone remodeling markers in hypertensive patients with and without diabetes mellitus: link between bone and glucose metabolism.

      Diabetes Metab Res Rev. 2015 Jun 4; Authors: Feldbrin Z, Shargorodsky M

      OBJECTIVE: Growing evidence suggests the presence of a complex interplay between hypertension as well as type 2 diabetes mellitus (DM) and... Lees meer

      Gepost op 07 June 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Patterns of Pharmacological Treatment for Osteoporosis Among Patients Qualified for Pharmacotherapy According to the National Osteoporosis Foundation Guidelines.

      Ann Pharmacother. 2015 Jun 3; Authors: Wang CC, Wu CH, Farley JF  

      BACKGROUND: Whereas the National Osteoporosis Foundation (NOF) guidelines suggest pharmacological treatment for patients at high risk of... Lees meer

      Gepost op 07 June 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Adjuvant denosumab in breast cancer (ABCSG-18): a multicentre, randomised, double-blind, placebo-controlled trial.

      Lancet. 2015 May 29; Authors: Gnant M, Pfeiler G, Dubsky PC, Hubalek M, Greil R, Jakesz R, Wette V, Balic M, Haslbauer F, Melbinger E, Bjelic-Radisic V, Artner-Matuschek S, Fitzal F, Marth C, Sevelda P, Mlineritsch B, Steger... Lees meer

      Gepost op 07 June 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Melatonin improves bone mineral density (BMD) at the femoral neck in post-menopausal women with osteopenia: A randomized controlled trial.

      J Pineal Res. 2015 Jun 3; Authors: Amstrup AK, Sikjaer T, Heickendorff L, Mosekilde L, Rejnmark L 

      Melatonin is known for its regulation of circadian rhythm. Recently, studies have shown that melatonin may... Lees meer

      Gepost op 07 June 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Denosumab in hypercalcemia of malignancy: A case series

      Lees meer

      Gepost op 07 June 2015

      Bron: http://www.medworm.com/inde....

    • Surgical versus non-surgical treatment for vertebral compression fracture with osteopenia: a systematic review and meta-analysis.

      PLoS One. 2015;10(5):e0127145 Authors: Guo JB, Zhu Y, Chen BL, Xie B, Zhang WY, Yang YJ, Yue YS, Wang XQ 

      BACKGROUND: Surgical and non-surgical interventions are the two categories for treatment of vertebral... Lees meer

      Gepost op 30 May 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Persistence, adherence, and medication-taking behavior in women with postmenopausal osteoporosis receiving denosumab in routine practice in Germany, Austria, Greece, and Belgium: 12-month results from a European non-interventional study.

      Osteoporos Int. 2015 May 28; Authors: Hadji P, Papaioannou N, Gielen E, Feudjo Tepie M, Zhang E, Frieling I, Geusens P, Makras P, Resch H, Möller G, Kalouche-Khalil L, Fahrleitner-Pammer A 

      INTRODUCTION:... Lees meer

      Gepost op 30 May 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • The Role of B-Vitamins in Bone Health and Disease in Older Adults.

      Curr Osteoporos Rep. 2015 May 28; Authors: Bailey RL, van Wijngaarden JP 

      The risk of osteoporosis and bone fractures increases with age. Several other factors are also related to bone disease including... Lees meer

      Gepost op 30 May 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Bone mineral density (BMD) and vertebral trabecular bone score (TBS) for the identification of elderly women at high risk for fracture: the SEMOF cohort study.

      Eur Spine J. 2015 May 27; Authors: Popp AW, Meer S, Krieg MA, Perrelet R, Hans D, Lippuner K 

      PURPOSE: To determine the predictive value of the vertebral trabecular bone score (TBS) alone or in addition to... Lees meer

      Gepost op 30 May 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Does Diet-Induced Weight Loss Lead to Bone Loss in Overweight or Obese Adults? A Systematic Review and Meta-Analysis of Clinical Trials.

      J Bone Miner Res. 2015 May 25; Authors: Zibellini J, Seimon RV, Lee CM, Gibson AA, Hsu MS, Shapses SA, Nguyen TV, Sainsbury A 

      Diet-induced weight loss has been suggested to be harmful to bone health. We... Lees meer

      Gepost op 30 May 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Hip fractures in the elderly caused by falls, not osteoporosis

      Anti-osteoporotic medication is not an effective means for preventing hip fractures among the elderly, concludes a study recently published in the BMJ. According to Professor Teppo Järvinen from the University of... Lees meer

      Gepost op 30 May 2015

      Bron: http://www.medworm.com/inde....

    • Baseline age and time to major fracture in younger postmenopausal women

      Lees meer

      Gepost op 30 May 2015

      Bron: http://www.medworm.com/inde....

    • Depression is associated with increased incidence of osteoporotic thoracolumbar fracture in postmenopausal women: a prospective study.

      Eur Spine J. 2015 May 23; Authors: Zong Y, Tang Y, Xue Y, Ding H, Li Z, He D, Zhao Y, Wang P 

      PROPOSE: To determine whether depression in postmenopausal women with osteoporosis is associated with an increased... Lees meer

      Gepost op 27 May 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Role of cortical bone in bone fragility.

      Curr Opin Rheumatol. 2015 May 21; Authors: Bala Y, Zebaze R, Seeman E 

      PURPOSE OF REVIEW: Trabecular bone loss and vertebral fractures are historical hallmarks of osteoporosis. During the past 70 years, this... Lees meer

      Gepost op 27 May 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Comparison of Percutaneous Vertebroplasty and Balloon Kyphoplasty for the Treatment of Single Level Vertebral Compression Fractures: A Meta-analysis of the Literature.

      Pain Physician. 2015 May-Jun;18(3):209-22 Authors: Wang H, Sribastav SS, Ye F, Yang C, Wang J, Liu H, Zheng Z 

      BACKGROUND: Percutaneous vertebroplasty (PVP) and percutaneous balloon kyphoplasty (PKP) can... Lees meer

      Gepost op 27 May 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • The relationship of thoracic kyphosis to gait performance and quality of life in women with osteoporosis.

      Osteoporos Int. 2015 May 21; Authors: Sangtarash F, Manshadi FD, Sadeghi A 

      INTRODUCTION: Osteoporosis and its related effects are threatening health and quality of life especially in postmenopausal women.... Lees meer

      Gepost op 27 May 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Preventive effects of conservative treatment with short-term teriparatide on the progression of vertebral body collapse after osteoporotic vertebral compression fracture.

      Osteoporos Int. 2014 Feb;25(2):613-8 Authors: Park JH, Kang KC, Shin DE, Koh YG, Son JS, Kim BH

      INTRODUCTION: Few studies have reported on the prevention of collapsed vertebral body progression after osteoporotic... Lees meer

      Gepost op 22 May 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Human stem cells may improve bone healing in diabetics

      Adding stem cells from human bone marrow to a broken diabetic bone enhances the repair process, increasing the strength of the newly formed bone, according to a laboratory-based study presented at the European Lees meer

      Gepost op 22 May 2015

      Bron: http://feeds.sciencedaily.c....

    • Predicting Hip Fracture Type with Cortical Bone Mapping (CBM) in the Osteoporotic Fractures in Men (MrOS) Study.

      J Bone Miner Res. 2015 May 18; Authors: Treece GM, Gee AH, Tonkin C, Ewing SK, Cawthon PM, Black DM, Poole KE, Osteoporotic Fractures in Men Study (MrOS) 

      Hip fracture risk is known to be related to material... Lees meer

      Gepost op 22 May 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Potassium Bicarbonate Supplementation Lowers Bone Turnover and Calcium Excretion in Older Men and Women: A Randomized Dose-Finding Trial.

      J Bone Miner Res. 2015 May 19; Authors: Dawson-Hughes B, Harris SS, Palermo NJ, Gilhooly CH, Shea MK, Fielding RA, Ceglia L

      The acid load accompanying modern diets may have adverse effects on bone and muscle... Lees meer

      Gepost op 22 May 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Trabecular bone score (TBS) as a new complementary approach for osteoporosis evaluation in clinical practice.

      Bone. 2015 May 16; Authors: Harvey NC, Glüer CC, Binkley N, McCloskey EV, Brandi ML, Cooper C, Kendler D, Lamy O, Laslop A, Camargos BM, Reginster JY, Rizzoli R, Kanis JA 

      Trabecular bone score (TBS) is a... Lees meer

      Gepost op 22 May 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Use of proton pump inhibitors is associated with fractures in young adults: a population-based study.

      Osteoporos Int. 2015 May 19; Authors: Freedberg DE, Haynes K, Denburg MR, Zemel BS, Leonard MB, Abrams JA, Yang YX 

      Proton pump inhibitors (PPIs) are associated with risk for fracture in osteoporotic adults.... Lees meer

      Gepost op 22 May 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Treatment satisfaction in postmenopausal women suboptimally adherent to bisphosphonates who transitioned to denosumab compared with risedronate or ibandronate.

      J Clin Endocrinol Metab. 2015 Mar;100(3):E487-92. Palacios S, Agodoa I,... Lees meer

      Gepost op 17 May 2015

      Bron: http://www.medworm.com/inde....

    • Anti-osteoporosis drug prescribing after hip fracture in the UK: 2000-2010

      Osteoporos Int. 2015 May 12. Klop C, Gibson-Smith D,... Lees meer

      Gepost op 17 May 2015

      Bron: http://www.medworm.com/inde....

    • 7 Tesla MRI of bone microarchitecture discriminates between women without and with fragility fractures who do not differ by bone mineral density

      Lees meer

      Gepost op 17 May 2015

      Bron: http://www.medworm.com/inde....

    • Bone Loss in Obesity and Obstructive Sleep Apnea: A Review of Literature

      J Clin Sleep Med 2015;11(5):575–580. Chakhtoura M, Nasrallah M, Chami H.

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      Gepost op 17 May 2015

      Bron: http://www.medworm.com/inde....

    • Weight-Loss Surgery and Women's Osteoporosis Risk

      Ahlin S. et al. 2015 European Congress on Obesity.

      ... Lees meer

      Gepost op 17 May 2015

      Bron: http://www.medworm.com/inde....

    • Hypercalciuria may persist after successful parathyroid surgery and it is associated with parathyroid hyperplasia.

      J Clin Endocrinol Metab. 2015 May 8;:jc20144548 Authors: Palmieri S, Eller-Vainicher C, Cairoli E, Morelli V, Zhukouskaya VV, Verga U, Filopanti M, Vicentini L, Ferrero S, Spada A, Chiodini I

      CONTEXT:... Lees meer

      Gepost op 10 May 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Serum 25-Hydroxyvitamin D Levels: Variability, Knowledge Gaps, and the Concept of a Desirable Range.

      J Bone Miner Res. 2015 May 7; Authors: El-Hajj Fuleihan G, Bouillon R, Clarke B, Chakhtoura M, Cooper C, McClung M, Singh RJ 

      Hypovitaminosis D is prevalent worldwide but proportions vary widely between... Lees meer

      Gepost op 10 May 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Presentation and management of osteoporosis presenting in association with pregnancy or lactation.

      Osteoporos Int. 2015 May 5; Authors: Kovacs CS, Ralston SH 

      In this review, we summarize our current understanding of the pathophysiology of fragility fractures that occur for the first time during pregnancy... Lees meer

      Gepost op 07 May 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Efficacy of bisphosphonates against osteoporosis in adult men: a meta-analysis of randomized controlled trials.

      Osteoporos Int. 2015 May 6; Authors: Chen L, Wang G, Zheng F, Zhao H, Li H

      INTRODUCTION: Bisphosphonates are well-investigated antiresorptive medications, approved as first-line drugs for osteoporosis in... Lees meer

      Gepost op 07 May 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Effects of eldecalcitol on bone and skeletal muscles in glucocorticoid-treated rats.

      J Bone Miner Metab. 2015 May 6; Authors: Kinoshita H, Miyakoshi N, Kasukawa Y, Sakai S, Shiraishi A, Segawa T, Ohuchi K, Fujii M, Sato C, Shimada Y

      Glucocorticoids cause secondary osteoporosis and myopathy,... Lees meer

      Gepost op 07 May 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Bone Material Properties and Skeletal Fragility.

      Calcif Tissue Int. 2015 May 5; Authors: Fyhrie DP, Christiansen BA

      Deformations of vertebrae and sudden fractures of long bones caused by essentially normal loading are a characteristic problem in osteoporosis. If... Lees meer

      Gepost op 07 May 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Teriparatide Therapy Reduces Serum Phosphate and Intima-Media Thickness at the Carotid Wall Artery in Patients with Osteoporosis.

      Calcif Tissue Int. 2015 May 1; Authors: Yoda M, Imanishi Y, Nagata Y, Ohara M, Yoda K, Yamada S, Mori K, Inaba M 

      Although cross-sectional and longitudinal studies report a relationship between osteoporosis... Lees meer

      Gepost op 02 May 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • The Effects of Bazedoxifene on Bone Structural Strength Evaluated by Hip Structure Analysis.

      Bone. 2015 Apr 23; Authors: Beck TJ, Fuerst T, Gaither KW, Sutradhar S, Levine AB, Hines T, Yu CR, Williams R, Mirkin S, Chines AA 

      Bazedoxifene (BZA) is a selective estrogen receptor modulator that has been... Lees meer

      Gepost op 02 May 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Comparison between frailty index of deficit accumulation and fracture risk assessment tool (FRAX) in prediction of risk of fractures.

      Bone. 2015 Apr 24; Authors: Li G, Thabane L, Papaioannou A, Adachi JD Abstract A frailty index (FI) of deficit accumulation could quantify and predict the risk of fractures based on the degree of frailty in the elderly. We... Lees meer

      Gepost op 02 May 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • 5-year follow-up of a randomized controlled trial of immediate versus delayed zoledronic acid for the prevention of bone loss in postmenopausal women with breast cancer starting letrozole after tamoxifen: N03CC (Alliance) trial.

      Cancer. 2015 Apr 30; Authors: Wagner-Johnston ND, Sloan JA, Liu H, Kearns AE, Hines SL, Puttabasavaiah S, Dakhil SR, Lafky JM, Perez EA, Loprinzi CL 

      BACKGROUND: Postmenopausal women with breast cancer... Lees meer

      Gepost op 02 May 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • The clinical use of vitamin D metabolites and their potential developments: a position statement from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) and the International Osteoporosis Foundation (IOF).

      Endocrine. 2015 May 1; Authors: Cianferotti L, Cricelli C, Kanis JA, Nuti R, Reginster JY, Ringe JD, Rizzoli R, Brandi ML 

      Several compounds are produced along the complex pathways of vitamin D3 metabolism,... Lees meer

      Gepost op 02 May 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • The Declining Use of Bone Densitometry

      The use of bone densitometry in the USA in postmenopausal women between the ages of 50 and 64 years has decreased: from 149 per 1,000 person-years in 2009 to 110 per 1,000 person-years in 2012. These findings by Overman... Lees meer

      Gepost op 02 May 2015

      Bron: http://www.medworm.com/inde....

    • Randomised controlled trial of the effectiveness of community group and home-based falls prevention exercise programmes on bone health in older people: the ProAct65+ bone study.

      Age Ageing. 2015 Apr 23; Authors: Duckham RL, Masud T, Taylor R, Kendrick D, Carpenter H, Iliffe S, Morris R, Gage H, Skelton DA, Dinan-Young S, Brooke-Wavell K 

      BACKGROUND: exercise can reduce osteoporotic... Lees meer

      Gepost op 29 April 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Tooth extraction in patients receiving oral or intravenous bisphosphonate administration: a trigger for BRONJ development?

      Conclusion: Tooth extraction in patients receiving bisphosphonates can be performed in a safe and predictable way, even in high-risk patients, when performed according to established guidelines. It is not tooth extractions... Lees meer

      Gepost op 29 April 2015

      Bron: http://www.medworm.com/inde....

    • Adherence to oral bisphosphonates and the risk of subtrochanteric and femoral shaft fractures among female medicare beneficiaries.

      Osteoporos Int. 2014 Aug;25(8):2109-16 Authors: Wang Z, Ward MM, Chan L, Bhattacharyya T

      INTRODUCTION: Long-term use of oral bisphosphonates has been implicated in an increased risk of atypical femur fractures... Lees meer

      Gepost op 22 April 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Fracture risk in adult patients treated with growth hormone replacement therapy for growth hormone deficiency: a prospective observational cohort study.

      Lancet Diabetes Endocrinol. 2015 Apr 10; Authors: Mo D, Fleseriu M, Qi R, Jia N, Child CJ, Bouillon R, Hardin DS 

      BACKGROUND: To our knowledge, no controlled studies of the effects of long-term growth hormone... Lees meer

      Gepost op 18 April 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Mapping trabecular disconnection "hotspots"in aged human spine and hip.

      Bone. 2015 Apr 12; Authors: Aaron JE, Shore PA, Itoda M, Morrison RJ, Hartopp A, Hensor EM, Hordon LD 

      Trabecular bone disconnection is an independent factor in age-related skeletal failure where real termini... Lees meer

      Gepost op 18 April 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • A Single 60 mg Dose of Denosumab Might Improve Hepatic Insulin Sensitivity in Postmenopausal Nondiabetic Severe Osteoporotic Women.

      Int J Endocrinol. 2015;2015:352858 Authors: Passeri E, Benedini S, Costa E, Corbetta S 

      Background. The RANKL/RANK/OPG signaling pathway is crucial for the regulation of osteoclast activity and bone resorption... Lees meer

      Gepost op 18 April 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • The Carcinogenicity of Alendronate in Patients with Osteoporosis: Evidence from Cohort Studies.

      PLoS One. 2015;10(4):e0123080 Authors: Chen LX, Ning GZ, Zhou ZR, Li YL, Zhang D, Wu QL, Zhang TS, Cheng L, Feng SQ 

      CONTEXT: Alendronate may relate to the incidence of cancers, especially esophageal and colon... Lees meer

      Gepost op 18 April 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Impact of Bisphosphonate-related Osteonecrosis of the Jaw on Osteoporotic Patients after Dental Extraction: A Population-Based Cohort Study.

      PLoS One. 2015;10(4):e0120756 Authors: Huang YF, Chang CT, Muo CH, Tsai CH, Shen YF, Wu CZ 

      BACKGROUND AND AIMS: Little is currently known about the risk of developing bisphosphonate-related osteonecrosis of... Lees meer

      Gepost op 18 April 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Measurement of cortical porosity of the proximal femur improves identification of women with nonvertebral fragility fractures.

      Osteoporos Int. 2015 Apr 16; Authors: Ahmed LA, Shigdel R, Joakimsen RM, Eldevik OP, Eriksen EF, Ghasem-Zadeh A, Bala Y, Zebaze R, Seeman E, Bjørnerem Å

      INTRODUCTION: Neither aBMD nor the FRAX captures... Lees meer

      Gepost op 18 April 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Bisphosphonates and Risk of Cardiovascular Events: A Meta-Analysis.

      PLoS One. 2015;10(4):e0122646 Authors: Kim DH, Rogers JR, Fulchino LA, Kim CA, Solomon DH, Kim SC 

      BACKGROUND AND OBJECTIVES: Some evidence suggests that bisphosphonates may reduce atherosclerosis, while... Lees meer

      Gepost op 18 April 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Efficacy and Safety of Single-Dose Zoledronic Acid for Osteoporosis in Frail Elderly Women: A Randomized Clinical Trial.

      JAMA Intern Med. 2015 Apr 13; Authors: Greenspan SL, Perera S, Ferchak MA, Nace DA, Resnick NM

      Importance: Eighty-five percent of institutionalized elderly people have osteoporosis and bone fracture rates 8 to 9... Lees meer

      Gepost op 15 April 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Gastrointestinal Events Among Patients Initiating Osteoporosis Therapy: A Retrospective Administrative Claims Database Analysis.

      Clin Ther. 2015 Apr 9; Authors: Modi A, Siris ES, Steve Fan CP, Sajjan S

      PURPOSE: Our purpose was to characterize the occurrence of gastrointestinal (GI) events among women on oral bisphosphonate therapy. METHODS:... Lees meer

      Gepost op 15 April 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Use of Oral Bisphosphonates in Primary Prevention of Fractures in Postmenopausal Women: A Population-Based Cohort Study.

      PLoS One. 2015;10(4):e0118178 Authors: Real J, Galindo G, Galván L, Lafarga MA, Rodrigo MD, Ortega M 

      OBJECTIVE: To compare incidence of first osteoporotic fracture in two cohorts of postmenopausal... Lees meer

      Gepost op 13 April 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Meeting international standards of secondary fracture prevention: a survey on Fracture Liaison Services in the Netherlands.

      Osteoporos Int. 2015 Apr 10; Authors: van den Berg P, Schweitzer DH, van Haard PM, van den Bergh JP, Geusens PP

      The Fracture Liaison Service (FLS) is advocated to be effective for the prevention of secondary... Lees meer

      Gepost op 13 April 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Impact of treatment with inhaled corticosteroids on bone mineral density of patients with asthma: related with age.

      Osteoporos Int. 2015 Apr 10; Authors: Monadi M, Javadian Y, Cheraghi M, Heidari B, Amiri M  

      INTRODUCTION: The results of studies... Lees meer

      Gepost op 13 April 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Osteoporosis and bone fractures in alcoholic liver disease: A meta-analysis.

      World J Gastroenterol. 2015 Apr 7;21(13):4038-47 Authors: Bang CS, Shin IS, Lee SW, Kim JB, Baik GH, Suk KT, Yoon JH, Kim YS, Kim DJ

      AIM: To evaluate the association between alcoholic liver disease (ALD) and bone... Lees meer

      Gepost op 13 April 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Prior ankle fractures in postmenopausal women are associated with low areal bone mineral density and bone microstructure alterations.

      Osteoporos Int. 2015 Apr 8; Authors: Biver E, Durosier C, Chevalley T, Herrmann FR, Ferrari S, Rizzoli R

      INTRODUCTION: Whether ankle fractures represent fragility fractures associated with low areal bone mineral... Lees meer

      Gepost op 13 April 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Fracture prevention in COPD patients; a clinical 5-step approach.

      Respir Res. 2015;16(1):32 Authors: Romme EA, Geusens P, Lems WF, Rutten EP, Smeenk FW, van den Bergh JP, van Hal PT, Wouters EF 

      Although osteoporosis and its related fractures are common in patients with... Lees meer

      Gepost op 08 April 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • The WNT system: background and its role in bone.

      J Intern Med. 2015 Apr 2; Authors: Lerner UH, Ohlsson C 

      WNTs are extracellular proteins that activate different cell surface receptors linked to canonical and non-canonical WNT signalling pathways. The Wnt... Lees meer

      Gepost op 08 April 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Fracture predictive ability of physical performance tests and history of falls in elderly women: a 10-year prospective study.

       Lees meer

      Gepost op 04 April 2015

      Bron: http://www.medworm.com/inde....

    • Long-term persistence with anti-osteoporosis drugs after fracture.

      Lees meer

      Gepost op 04 April 2015

      Bron: http://www.medworm.com/inde....

    • Statin therapy and risk of fracture: results from the JUPITER randomized clinical trial.

       

      Lees meer

      Gepost op 04 April 2015

      Bron: http://www.medworm.com/inde....

    • Mortality in British hip fracture patients, 2000-2010: a population-based retrospective cohort study.

      Lees meer

      Gepost op 04 April 2015

      Bron: http://www.medworm.com/inde....

    • Disability-adjusted-life-years losses in postmenopausal women with osteoporosis: a burden of illness study

      BMC Public... Lees meer

      Gepost op 04 April 2015

      Bron: http://www.medworm.com/inde....

    • Oral Bisphosphonate Use and Risk of Postmenopausal Endometrial Cancer

      Journal of Clinical Oncology 2015. P.A. Newcomb, M.N. Passarelli, A.I. Phipps, G.L Anderson, J. Wactawski-Wende, G.Y.F. Ho, M.J. O'Sullivand, R.T. Chlebowski 

      ... Lees meer

      Gepost op 04 April 2015

      Bron: http://www.medworm.com/inde....

    • Hip fracture patients in long-term care are less likely to receive osteoporosis therapy

      Canadian researchers calculated the proportion of high-risk residents of long-term care homes receiving osteoporosis medications and vitamin D supplementation according to specific high-risk categories. Marked undertreatment... Lees meer

      Gepost op 04 April 2015

      Bron: http://www.medworm.com/inde....

    • Reactive oxygen species and oxidative stress in osteoclastogenesis, skeletal aging and bone diseases.

      J Bone Miner Metab. 2015 Mar 26; Authors: Callaway DA, Jiang JX 

      Osteoclasts are cells derived from bone marrow macrophages and are important in regulating bone resorption during bone homeostasis.... Lees meer

      Gepost op 29 March 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Hyponatremia and osteoporosis: reappraisal of a novel association.

      Osteoporos Int. 2015 Mar 26; Authors: Afshinnia F, Sundaram B, Ackermann RJ, Wong KK

      INTRODUCTION: Epidemiologic studies provide conflicting results on the relationship between hyponatremia and OP. Our aim is to... Lees meer

      Gepost op 29 March 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • The risk of osteoporosis in patients with liver cirrhosis: a meta‐analysis of literature studies

      Clinical Endocrinology 2015. Roberta Lupoli, Alessandro Di Minno, Gaia Spadarella, Pasquale Ambrosino, Annalisa Panico, Luciano Tarantino, Gelsy Lupoli, Giovanni Lupoli and Matteo Nicola Dario Di Minno.

      ... Lees meer

      Gepost op 29 March 2015

      Bron: http://www.medworm.com/inde....

    • Hypocalcemia Post Denosumab in Patients with Chronic Kidney Disease Stage 4-5.

      Am J Nephrol. 2015 Mar 18;41(2):129-137 Authors: Dave V, Chiang CY, Booth J, Mount PF 

      BACKGROUND: Denosumab, a RANK-ligand inhibitor, is an effective treatment for osteoporosis in postmenopausal women and... Lees meer

      Gepost op 22 March 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Temporal correlation between bisphosphonate termination and symptom resolution in osteonecrosis of the jaw: a pooled case report analysis.

      J Oral Maxillofac Surg. 2015 Jan;73(1):53-62 Authors: Hinson AM, Siegel ER, Stack BC 

      PURPOSE: To investigate whether termination of bisphosphonates (BPs) affects resolution of bone exposure and symptomatic... Lees meer

      Gepost op 22 March 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Postmenopausal weight change and incidence of fracture: post hoc findings from Women's Health Initiative Observational Study and Clinical Trials.

      BMJ. 2015;350:h25 Authors: Crandall CJ, Yildiz VO, Wactawski-Wende J, Johnson KC, Chen Z, Going SB, Wright NC, Cauley JA 

      OBJECTIVES: To determine associations between postmenopausal change in body weight and... Lees meer

      Gepost op 20 March 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • FRAX (Aus) and falls risk: Association in men and women.

      Bone. 2015 Mar 11; Authors: Holloway KL, Kotowicz MA, Lane SE, Brennan SL, Pasco JA 

      PURPOSE: The WHO fracture risk prediction tool (FRAX®) utilises clinical risk factors to estimate the probability of... Lees meer

      Gepost op 20 March 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Roles of leptin in bone metabolism and bone diseases.

      J Bone Miner Metab. 2015 Mar 18; Authors: Chen XX, Yang T 

      Adipose tissue has been more accepted as an active contributor to whole body homeostasis, rather than just a fat depot, since leptin, a 16 kDa... Lees meer

      Gepost op 20 March 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Increased Cortical Porosity in Older Men with Fracture.

      J Bone Miner Res. 2015 Mar 16; Authors: Sundh D, Mellström D, Nilsson M, Karlsson M, Ohlsson C, Lorentzon M 

      Cortical porosity increases with age and affects bone strength, but its association with... Lees meer

      Gepost op 20 March 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Fracture prevention in COPD patients; a clinical 5-step approach.

      Respir Res. 2015 Dec;16(1):192 Authors: Romme EA, Geusens P, Lems WF, Rutten EP, Smeenk FW, van den Bergh JP, van Hal PT, Wouters EF 

      Although osteoporosis and its related fractures are common in patients with... Lees meer

      Gepost op 20 March 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Increased Incidence of Fractures in Recipients of Hematopoietic Stem-Cell Transplantation.

      J Clin Oncol. 2015 Mar 16; Authors: Pundole XN, Barbo AG, Lin H, Champlin RE, Lu H 

      PURPOSE: The number of long-term survivors after hematopoietic stem-cell transplantation (HSCT) for malignant and... Lees meer

      Gepost op 20 March 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Bone Material Strength as measured by microindentation in vivo is decreased in patients with fragility fractures independently of Bone Mineral Density.

      J Clin Endocrinol Metab. 2015 Mar 13;:jc20144346 Authors: Malgo F, Hamdy NA, Papapoulos SE, Appelman-Dijkstra NM 

      CONTEXT: Bone Mineral Density (BMD) does not fully capture fracture risk as the majority of... Lees meer

      Gepost op 16 March 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Male smokers have elevated risk of osteoporosis

      Male smokers have a greater risk for osteoporosis than other men and even than women smokers, a recent study finds, suggesting that U.S. screening guidelines focused on women might need to be expanded to include men.

      ... Lees meer

      Gepost op 16 March 2015

      Bron: http://www.medworm.com/inde....

    • Risk factors influencing the duration of treatment with bisphosphonates until occurrence of an osteonecrosis of the jaw in 963 cancer patients

      Journal of Cancer Research and Clinical Oncology, 

      Gepost op 16 March 2015

      Bron: http://www.medworm.com/inde....

    • Bone Muscle Interactions and Vitamin D.

      Bone. 2015 Mar 5; Authors: Gunton JE, Irgis CM, Baldock PA, Lips P 

      Beyond the established roles of vitamin D in bone and mineral homeostasis, we are becoming increasingly aware of its diverse effects in... Lees meer

      Gepost op 11 March 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Associations between medication use and homocysteine levels in an older population, and potential mediation by vitamin B12 and folate: data from the B-PROOF Study.

      Drugs Aging. 2014 Aug;31(8):611-21 Authors: Ham AC, Enneman AW, van Dijk SC, Oliai Araghi S, Swart KM, Sohl E, van Wijngaarden JP, van der Zwaluw NL, Brouwer-Brolsma EM, Dhonukshe-Rutten RA, van Schoor NM, van der Cammen TJ,... Lees meer

      Gepost op 11 March 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Risk of atrial fibrillation among bisphosphonate users: a multicenter, population-based, Italian study

      Osteoporosis International, march 2015. Lees meer

      Gepost op 11 March 2015

      Bron: http://www.medworm.com/inde....

    • Investigational osteoporosis drug, abaloparatide, lowers fracture risk

      Lees meer

      Gepost op 07 March 2015

      Bron: http://feeds.sciencedaily.c....

    • Co-Administration of Antiresorptive and Anabolic Agents: A Missed Opportunity.

       J Bone Miner Res. 2015 Mar 4; Authors: Seeman E, Martin T 

      Co-administration of antiresorptive and anabolic therapies has appeal because these treatments target the two main abnormalities in bone... Lees meer

      Gepost op 07 March 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Changes in bone mineral density at 3 years in postmenopausal women receiving anastrozole and risedronate in the IBIS-II bone substudy: an international, double-blind, randomised, placebo-controlled trial.

      Lancet Oncol. 2014 Dec;15(13):1460-8 Authors: Sestak I, Singh S, Cuzick J, Blake GM, Patel R, Gossiel F, Coleman R, Dowsett M, Forbes JF, Howell A, Eastell R 

      BACKGROUND: Aromatase inhibitors prevent breast... Lees meer

      Gepost op 07 March 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Effects of zoledronic acid on bone mineral density in premenopausal women receiving neoadjuvant or adjuvant therapies for HR+ breast cancer: the ProBONE II study.

      Osteoporos Int. 2014 Apr;25(4):1369-78 Authors: Hadji P, Kauka A, Ziller M, Birkholz K, Baier M, Muth M, Bauer M

      INTRODUCTION: Adjuvant chemotherapy or endocrine therapy for early hormone receptor-positive breast... Lees meer

      Gepost op 07 March 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Compliance and persistence to oral bisphosphonate therapy following initiation within a secondary fracture prevention program: a randomised controlled trial of specialist vs. non-specialist management.

      Osteoporos Int. 2014 Apr;25(4):1345-55 Authors: Ganda K, Schaffer A, Pearson S, Seibel MJ

      INTRODUCTION: The purpose of this study was to determine whether management by a secondary fracture prevention (SFP) program... Lees meer

      Gepost op 07 March 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • De dia's van de stemvragen van de Osteoporosedag der Lage Landen 2014 zijn nu beschikbaar op de website

      De dia's van de stemvragen van de Lage Landen Meeting 2014 zijn nu beschikbaar op de website. De dia's zijn terug te vinden op de website onder: Seminars - Nascholingen 2006-2014 - Osteoporosedag der Lage Landen... Lees meer

      Gepost op 01 March 2015

      Bron: http://news.google.com/news....

    • Risk of fractures in subjects with antihypertensive medications: A nationwide claim study.

      Int J Cardiol. 2015 Jan 28;184C:62-67 Authors: Choi HJ, Park C, Lee YK, Ha YC, Jang S, Shin CS

      BACKGROUND: The effect of antihypertensives on fracture has important clinical implications, since antihypertensives... Lees meer

      Gepost op 26 February 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Validation of FRAX without BMD: An age-related analysis of the Fifth Korean National Health and Nutrition Examination Survey (KNHANES V-1, 2010).

      Bone. 2015 Feb 17;75C:27-31 Authors: Kim JW, Koh JM, Park JH, Chang JS 

      Although the Fracture Risk Assessment Tool (FRAX) is widely used to evaluate probabilities of fractures, there is no consensus regarding... Lees meer

      Gepost op 26 February 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Sodium homeostasis and bone.

      Curr Opin Nephrol Hypertens. 2014 Jul;23(4):370-6 Authors: Hannon MJ, Verbalis JG 

      PURPOSE OF REVIEW: Sodium balance is primarily regulated through the renin-angiotensin-aldosterone system. Extracellular fluid... Lees meer

      Gepost op 26 February 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Once-weekly teriparatide reduces the risk of vertebral fracture in patients with various fracture risks: subgroup analysis of the Teriparatide Once-Weekly Efficacy Research (TOWER) trial.

      J Bone Miner Metab. 2014 Jul;32(4):441-6 Authors: Nakano T, Shiraki M, Sugimoto T, Kishimoto H, Ito M, Fukunaga M, Hagino H, Sone T, Kuroda T, Nakamura T 

      Once-weekly teriparatide (human parathyroid hormone... Lees meer

      Gepost op 26 February 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Oral Anticoagulant Drugs and the Risk of Osteoporosis: New Anticoagulants Better than Old?

      Semin Thromb Hemost. 2015 Feb 19; Authors: Tufano A, Coppola A, Contaldi P, Franchini M, Minno GD 

      Several drugs have been associated with an increased risk of osteoporosis when used chronically. Coumarins... Lees meer

      Gepost op 26 February 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Can We Identify Patients with High Risk of Osteoarthritis Progression Who Will Respond to Treatment? A Focus on Epidemiology and Phenotype of Osteoarthritis.

      Drugs Aging. 2015 Feb 21; Authors: Bruyère O, Cooper C, Arden N, Branco J, Brandi ML, Herrero-Beaumont G, Berenbaum F, Dennison E, Devogelaer JP, Hochberg M, Kanis J, Laslop A, McAlindon T, Reiter S, Richette P,... Lees meer

      Gepost op 26 February 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Oral Bisphosphonate Use and Risk of Postmenopausal Endometrial Cancer.

      J Clin Oncol. 2015 Feb 23; Authors: Newcomb PA, Passarelli MN, Phipps AI, Anderson GL, Wactawski-Wende J, Ho GY, O'Sullivan MJ, Chlebowski RT

      PURPOSE: Bisphosphonates are common medications used for the... Lees meer

      Gepost op 26 February 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Risk of Hospitalized Infection among Biologic-Treated Rheumatoid Arthritis Patients Concurrently Treated with Denosumab.

      Arthritis Rheumatol. 2015 Feb 23; Authors: Curtis JR, Xie F, Yun H, Saag KG, Chen L, Delzell E 

      Background Denosumab 60mg is a biologic used to treat osteoporosis. Its safety profile given concurrently with... Lees meer

      Gepost op 26 February 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • The Effect of Discontinuing Treatment with Blosozumab: Follow-up Results of a Phase 2 Randomized Clinical Trial in Postmenopausal Women with Low Bone Mineral Density.

      J Bone Miner Res. 2015 Feb 24; Authors: Recknor CP, Recker RR, Benson CT, Robins DA, Chiang AY, Alam J, Hu L, Matsumoto T, Sowa H, Sloan JH, Konrad RJ, Mitlak BH, Sipos AA 

      Administration of blosozumab, a... Lees meer

      Gepost op 26 February 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Deteriorating Effect on Bone Metabolism and Microstructure by Passive Cigarette Smoking Through Dual Actions on Osteoblast and Osteoclast.

      Calcif Tissue Int. 2015 Feb 20; Authors: Ko CH, Chan RL, Siu WS, Shum WT, Leung PC, Zhang L, Cho CH 

      There is no clear evidence to show the direct causal relationship between passive cigarette smoking and... Lees meer

      Gepost op 22 February 2015

      Bron: http://www.ncbi.nlm.nih.gov....

    • Oral Anticoagulant Drugs and the Risk of Osteoporosis: New Anticoagulants Better than Old?

      Semin Thromb Hemost 2015. Antonella TufanoLees meer

      Gepost op 22 February 2015

      Bron: http://www.medworm.com/inde....

    • Can We Identify Patients with High Risk of Osteoarthritis Progression Who Will Respond to Treatment? A Focus on Epidemiology and Phenotype of Osteoarthritis

      Lees meer

      Gepost op 22 February 2015

      Bron: http://www.medworm.com/inde....

    • Impact of Anti-hyperglycemic Medications on Bone Health

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        Gepost op 18 February 2015

        Bron: http://www.medworm.com/inde....

      • Relationship Between Pretreatment Rate of Bone Loss and Bone Density Response to Once‐Yearly ZOL: HORIZON‐PFT Extension Study

        Lees meer

        Gepost op 18 February 2015

        Bron: http://www.medworm.com/inde....

      • Use of osteoporosis medications after hospitalization for hip fracture: a cross-national study.

        Am J Med. 2015 Feb 3; Authors: Kim SC, Kim MS, Sanfélix-Gimeno G, Song HJ, Liu J, Hurtado I, Peiró S, Lee J, Choi NK, Park BJ, Avorn J

        PURPOSE: While current osteoporosis management guidelines... Lees meer

        Gepost op 12 February 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • A 7-year randomized, placebo-controlled trial assessing the long-term efficacy and safety of bazedoxifene in postmenopausal women with osteoporosis: effects on bone density and fracture.

        Menopause. 2015 Feb 9; Authors: Palacios S, Silverman SL, de Villiers TJ, Levine AB, Goemaere S, Brown JP, De Cicco Nardone F, Williams R, Hines TL, Mirkin S, Chines AA, on behalf of the Bazedoxifene Study Group 

        ... Lees meer

        Gepost op 12 February 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Risk of Fracture and the Concomitant Use of Bisphosphonates With Osteoporosis-Inducing Medications.

        Ann Pharmacother. 2015 Feb 9; Authors: Nyandege AN, Slattum PW, Harpe SE 

        OBJECTIVE: To review the literature on the concomitant use of bisphosphonates and medications that can influence bone metabolism and... Lees meer

        Gepost op 12 February 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Schizophrenia and the risk of fractures: a systematic review and comparative meta-analysis.

        Gen Hosp Psychiatry. 2015 Jan 15; Authors: Stubbs B, Gaughran F, Mitchell AJ, De Hert M, Farmer R, Soundy A, Rosenbaum S, Vancampfort D 

        BACKGROUND: People with schizophrenia experience increased rates of... Lees meer

        Gepost op 12 February 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Comparison of Fracture Risk Prediction among Individuals with Reduced and Normal Kidney Function.

        Lees meer

        Gepost op 12 February 2015

        Bron: http://www.medworm.com/inde....

      • Inflammatory eye reactions with bisphosphonates and other osteoporosis medications: what are the risks?

        Ther Adv Musculoskelet Dis. 2015 Feb;7(1):11-6 Authors: Clark EM, Durup D 

        Inflammatory eye reactions (IERs) are rare but have been associated with medications to treat osteoporosis. The aim of this review is... Lees meer

        Gepost op 07 February 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Diabetes, Diabetic Complications, and Fracture Risk.

        Curr Osteoporos Rep. 2015 Feb 4; Authors: Oei L, Rivadeneira F, Zillikens MC, Oei EH

        Diabetes and osteoporosis are both common diseases with increasing prevalences in the aging population. There is increasing... Lees meer

        Gepost op 07 February 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Systematic review and meta-analysis of the performance of clinical risk assessment instruments for screening for osteoporosis or low bone density.

        Osteoporos Int. 2015 Feb 3; Authors: Nayak S, Edwards DL, Saleh AA, Greenspan SL

        INTRODUCTION: The purpose of the study is to systematically review the performance of clinical risk assessment instruments for... Lees meer

        Gepost op 07 February 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Revisiting KDIGO clinical practice guideline on chronic kidney disease-mineral and bone disorder: a commentary from a Kidney Disease: Improving Global Outcomes controversies conference.

        Kidney Int. 2015 Feb 4; Authors: Ketteler M, Elder GJ, Evenepoel P, Ix JH, Jamal SA, Lafage-Proust MH, Shroff R, Thadhani RI, Tonelli MA, Kasiske BL, Wheeler DC, Leonard MB 

        A new definition and classification... Lees meer

        Gepost op 07 February 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • The clinical epidemiology of male osteoporosis: a review of the recent literature.

        Clin Epidemiol. 2015;7:65-76 Authors: Willson T, Nelson SD, Newbold J, Nelson RE, LaFleur J 

        Osteoporosis, a musculoskeletal disease characterized by decreased bone mineral density (BMD) and an increased risk... Lees meer

        Gepost op 07 February 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Comparison of Fracture Risk Prediction among Individuals with Reduced and Normal Kidney Function.

        Clin J Am Soc Nephrol. 2015 Feb 5; Authors: Naylor KL, Garg AX, Zou G, Langsetmo L, Leslie WD, Fraser LA, Adachi JD, Morin S, Goltzman D, Lentle B, Jackson SA, Josse RG, Jamal SA 

        BACKGROUND AND OBJECTIVES:... Lees meer

        Gepost op 07 February 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Prevalence of osteoporosis in prostate cancer survivors II: a meta-analysis of men not on androgen deprivation therapy.

        Endocrine. 2015 Jan 31; Authors: Lassemillante AC, Doi SA, Hooper JD, Prins JB, Wright OR 

        The prevalence of osteoporosis in men with prostate cancer (PCa) on androgen deprivation therapy (ADT) is well... Lees meer

        Gepost op 02 February 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Prediction models of prevalent radiographic vertebral fractures among older men.

        J Clin Densitom. 2014 Oct-Dec;17(4):449-57 Authors: Schousboe JT, Rosen HR, Vokes TJ, Cauley JA, Cummings SR, Nevitt MC, Black DM, Orwoll ES, Kado DM, Ensrud KE, Osteoporotic Fractures in Men (MrOS) Study Research Group

        ... Lees meer

        Gepost op 31 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Greater milk intake is associated with lower bone turnover, higher bone density, and higher bone microarchitecture index in a population of elderly Japanese men with relatively low dietary calcium intake: Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Stu

        Osteoporos Int. 2015 Jan 28; Authors: Sato Y, Iki M, Fujita Y, Tamaki J, Kouda K, Yura A, Moon JS, Winzenrieth R, Iwaki H, Ishizuka R, Amano N, Tomioka K, Okamoto N, Kurumatani N

        INTRODUCTION: The consumption of... Lees meer

        Gepost op 31 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Eldecalcitol reduces osteoporotic fractures by unique mechanisms.

        J Steroid Biochem Mol Biol. 2015 Jan 24; Authors: Kondo S, Takano T, Ono Y, Saito H, Matsumoto T 

        Eldecalcitol shows higher binding affinity for vitamin D-binding protein (DBP), tighter binding to vitamin D... Lees meer

        Gepost op 31 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • High prevalence of fragility vertebral fractures in patients hospitalised in Internal Medicine Units. Results of the POINT (Prevalence of Osteoporosis in INTernal medicine) study.

        Bone. 2015 Jan 24;74C:114-120 Authors: Vitali C, Gussoni G, Bianchi G, Albanese CV, Diacinti D, Sinigaglia L, Nuti R, Muzzulini CL, Pintaudi C, Scanelli G, Magni G, Valerio A, Iori I, Mazzone A, Campanini M, for the Research... Lees meer

        Gepost op 31 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Improving adherence to and persistence with oral therapy of osteoporosis.

        Osteoporos Int. 2015 Jan 27; Authors: Bianchi ML, Duca P, Vai S, Guglielmi G, Viti R, Battista C, Scillitani A, Muscarella S, Luisetto G, Camozzi V, Nuti R, Caffarelli C, Gonnelli S, Albanese C, De Tullio V, Isaia G,... Lees meer

        Gepost op 31 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Fracture incidence in a large cohort of men age 30 years and older with osteoporosis.

        Osteoporos Int. 2015 Jan 24; Authors: Manthripragada AD, O'Malley CD, Gruntmanis U, Hall JW, Wagman RB, Miller PD

        INTRODUCTION: The purposes of this study were to describe a cohort of men with presumed... Lees meer

        Gepost op 31 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • US Preventative Services Task Force FRAX threshold has a low sensitivity to detect osteoporosis in women ages 50-64 years.

        Osteoporos Int. 2015 Jan 23; Authors: Bansal S, Pecina JL, Merry SP, Kennel KA, Maxson J, Quigg S, Thacher TD 

        INTRODUCTION: The US Preventative Services Task Force (USPSTF) recommends consideration of... Lees meer

        Gepost op 31 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • The genetics of osteoporosis.

        Br Med Bull. 2015 Jan 29; Authors: Clark GR, Duncan EL 

        INTRODUCTION: Osteoporosis is the commonest metabolic bone disease worldwide. The clinical hallmark of osteoporosis is low trauma fracture, with the most... Lees meer

        Gepost op 31 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Is calcaneal quantitative ultrasound useful as a prescreen stratification tool for osteoporosis?

        Osteoporos Int. 2015 Jan 30; Authors: Thomsen K, Jepsen DB, Matzen L, Hermann AP, Masud T, Ryg J

        Calcaneal quantitative ultrasound (QUS) is attractive as a prescreening tool for osteoporosis, alternative to... Lees meer

        Gepost op 31 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Integrated Therapies for Osteoporosis and Sarcopenia: From Signaling Pathways to Clinical Trials.

        Calcif Tissue Int. 2015 Jan 31; Authors: Girgis CM 

        Sarcopenia and osteoporosis are two sides of the same coin. They represent different aspects of the same age-related process of musculoskeletal atrophy and... Lees meer

        Gepost op 31 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Treatment of osteoporosis in renal insufficiency.

        Clin Rheumatol. 2015 Jan 29; Authors: Schipper LG, Fleuren HW, van den Bergh JP, Meinardi JR, Veldman BA, Kramers C 

        Patients with osteoporosis often have chronic kidney disease (CKD). CKD is associated with... Lees meer

        Gepost op 31 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Management of osteoporosis in rheumatoid arthritis patients

      • Patterns of Bisphosphonates Utilization in Patients under Age 45 in a Large Cohort of Commercial Insurance Beneficiaries in the United States.

        PLoS One. 2015;10(1):e0115091 Authors: Xie J, Tong A, Kim SC 

        BACKGROUND: The effectiveness and safety of bisphosphonates treatment used in the young population have not been well studied. Despite insufficient... Lees meer

        Gepost op 23 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Recommendations for Evaluation and Management of Bone Disease in HIV.

        Clin Infect Dis. 2015 Jan 21; Authors: Brown TT, Hoy J, Borderi M, Guaraldi G, Renjifo B, Vescini F, Yin MT, Powderly WG

        Thirty-four HIV specialists from 16 countries contributed to this project, whose primary aim... Lees meer

        Gepost op 23 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • A 24-month Study Evaluating the Efficacy and Safety of Denosumab for the Treatment of Men With Low Bone Mineral Density: Results From the ADAMO Trial.

        J Clin Endocrinol Metab. 2015 Jan 21;:jc20144079 Authors: Langdahl BL, Teglbjaerg CS, Ho PR, Chapurlat R, Czerwinski E, Kendler DL, Reginster JY, Kivitz A, Lewiecki EM, Miller PD, Bolognese MA, McClung MR, Bone HG, Ljunggren... Lees meer

        Gepost op 23 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • First quantification of calcium intake from calcium-dense dairy products in Dutch fracture patients (the Delft cohort study).

        Nutrients. 2014 Jun;6(6):2404-18 Authors: van den Berg P, van Haard PM, van den Bergh JP, Niesten DD, van der Elst M, Schweitzer DH 

        Recommendations for daily calcium intake from dairy products are variable... Lees meer

        Gepost op 23 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Fracture rate associated with quality metric-based anti-osteoporosis treatment in glucocorticoid-induced osteoporosis.

        Osteoporos Int. 2015 Jan 20; Authors: Overman RA, Gourlay ML, Deal CL, Farley JF, Brookhart MA, Layton JBMR

        INTRODUCTION: The purpose of this study is to explore the effectiveness of adherence to quality measures... Lees meer

        Gepost op 21 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Accelerated bone loss and increased post-fracture mortality in elderly women and men.

        Osteoporos Int. 2015 Jan 20; Authors: Bliuc D, Nguyen ND, Alarkawi D, Nguyen TV, Eisman JA, Center JR 

        INTRODUCTION: Osteoporotic fractures are associated with increased mortality although the cause is... Lees meer

        Gepost op 21 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Survival benefits of post-acute care for older patients with hip fractures in Taiwan: A 5-year prospective cohort study.

        Geriatr Gerontol Int. 2015 Jan 17; Authors: Peng LN, Chen WM, Chen CF, Huang CK, Lee WJ, Chen LK

        AIM: To evaluate the survival benefits of different models of post-acute care (PAC) services for older patients with... Lees meer

        Gepost op 21 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Parameters of bone health and fracture risk in older female fall victims: what do they tell us?

        Z Gerontol Geriatr. 2015 Jan 16; Authors: Thaler HW, Oudshoorn C, Hartholt KA, van der Cammen TJ

        INTRODUCTION: A common and severe osteoporotic type fracture in older women is a hip fracture. It is not clear... Lees meer

        Gepost op 21 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Reliability and validity of lower extremity computed tomography as a screening tool for osteoporosis.

        Osteoporos Int. 2015 Jan 16; Authors: Lee SY, Kwon SS, Kim HS, Yoo JH, Kim J, Kim JY, Min BC, Moon SJ, Sung KH

        INTRODUCTION: This study aimed to evaluate the reliability and validity of CT as a screening tool for... Lees meer

        Gepost op 21 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Efficacy of combined treatment with alendronate (ALN) and eldecalcitol, a new active vitamin D analog, compared to that of concomitant ALN, vitamin D plus calcium treatment in Japanese patients with primary osteoporosis.

        Osteoporos Int. 2015 Jan 16; Authors: Sakai A, Ito M, Tomomitsu T, Tsurukami H, Ikeda S, Fukuda F, Mizunuma H, Inoue T, Saito H, Nakamura T, e-ADVANCED Study Group

        INTRODUCTION: We compared the clinical efficacy... Lees meer

        Gepost op 21 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Opportunistic screening for osteoporosis on routine computed tomography? An external validation study.

        Eur Radiol. 2015 Jan 17; Authors: Buckens CF, Dijkhuis G, de Keizer B, Verhaar HJ, de Jong PA 

        OBJECTIVES: Opportunistic screening for osteoporosis using computed tomography (CT) examinations that happen to... Lees meer

        Gepost op 21 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Abnormalities in cortical bone, trabecular plates, and stiffness in postmenopausal women treated with glucocorticoids.

        J Clin Endocrinol Metab. 2014 Nov;99(11):4231-40 Authors: Sutter S, Nishiyama KK, Kepley A, Zhou B, Wang J, McMahon DJ, Guo XE, Stein EM

        CONTEXT: The mechanisms by which glucocorticoids (GCs) increase skeletal... Lees meer

        Gepost op 21 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • A model of BMD changes after alendronate discontinuation to guide postalendronate BMD monitoring.

        J Clin Endocrinol Metab. 2014 Nov;99(11):4094-100 Authors: McNabb B, Vittinghoff E, Eastell R, Schwartz AV, Bauer DC, Ensrud K, Barrett-Connor E, Black DM

        CONTEXT: Women stopping alendronate are commonly monitored... Lees meer

        Gepost op 21 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Potassium salts aid bone health, limit osteoporosis risk, new research finds

        Helen Lambert, Lynda Frassetto, J. Bernadette Moore, David Torgerson, Richard Gannon , Peter Burckhardt and Susan Lanham-New. The effect of supplementation with alkaline potassium salts on... Lees meer

        Gepost op 16 January 2015

        Bron: http://feeds.sciencedaily.c....

      • Treatment patterns for osteoporosis in elderly women residing in the community and in long‐term care facilities enrolled in Medicare

        Journal of Pharmaceutical Health Services Research. Article first published online: 15 JAN 2015. Feng-Hua Ellen Loh, Bruce Stuart and... Lees meer

        Gepost op 16 January 2015

        Bron: http://www.medworm.com/inde....

      • Increased risk of osteoporosis in patients with depression: a population-based retrospective cohort study.

        Mayo Clin Proc. 2015 Jan;90(1):63-70 Authors: Lee CW, Liao CH, Lin CL, Liang JA, Sung FC, Kao CH 

        OBJECTIVE: To investigate the relationship between depression and risk of subsequent osteoporosis development.... Lees meer

        Gepost op 13 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Regional variability in changes in the incidence of hip fracture in the Spanish population (2000-2012).

        Osteoporos Int. 2015 Jan 9; Authors: Etxebarria-Foronda I, Arrospide A, Soto-Gordoa M, Caeiro JR, Abecia LC, Mar J 

        INTRODUCTION: Fragility-related hip fractures are considered to be the fractures of greatest... Lees meer

        Gepost op 13 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Can vitamin D metabolite measurements facilitate a "treat-to-target" paradigm to guide vitamin D supplementation?

        Osteoporos Int. 2015 Jan 9; Authors: Binkley N, Lappe J, Singh RJ, Khosla S, Krueger D, Drezner MK, Blank RD 

        INTRODUCTION: Vitamin D supplementation produces a variable response in serum 25(OH)D. This... Lees meer

        Gepost op 13 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • The social gradient of fractures at any skeletal site in men and women: data from the Geelong Osteoporosis Study Fracture Grid.

        Osteoporos Int. 2015 Jan 9; Authors: Brennan SL, Holloway KL, Williams LJ, Kotowicz MA, Bucki-Smith G, Moloney DJ, Dobbins AG, Timney EN, Pasco JA 

        INTRODUCTION: The effective identification of predisposing... Lees meer

        Gepost op 13 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Trends in the incidence of hip fracture in Gran Canaria, Canary Islands, Spain: 2007-2011 versus 1989-1993.

        Osteoporos Int. 2015 Jan 9; Authors: Sosa M, Saavedra P, de Tejada MJ, Navarro M, Cabrera D, Melton LJ

        INTRODUCTION: A dramatic increase in hip fractures between 1988 and 2002 was... Lees meer

        Gepost op 13 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Effects of escitalopram on markers of bone turnover: a randomized clinical trial.

        J Clin Endocrinol Metab. 2014 Sep;99(9):E1732-7 Authors: Diem SJ, Joffe H, Larson JC, Tsai JN, Guthrie KA, LaCroix AZ, Ensrud KE, Freeman EW, Leder BZ 

        CONTEXT: Recent observational studies have suggested that... Lees meer

        Gepost op 13 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Circulating vitamin D, supplement use, and cardiovascular disease risk: the MrOS Sleep Study.

        J Clin Endocrinol Metab. 2014 Sep;99(9):3256-62 Authors: Bajaj A, Stone KL, Peters K, Parimi N, Barrett-Connor E, Bauer D, Cawthon PM, Ensrud KE, Hoffman AR, Orwoll E, Schernhammer ES 

        CONTEXT: Evidence... Lees meer

        Gepost op 13 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Is There an Interaction Between Socioeconomic Status and FRAX 10-Year Fracture Probability Determined With and Without Bone Density Measures? Data from the Geelong Osteoporosis Study of Female Cohort.

        Calcif Tissue Int. 2015 Jan 13; Authors: Brennan SL, Quirk SE, Hosking SM, Kotowicz MA, Holloway KL, Moloney DJ, Dobbins AG, Pasco JA 

        FRAX(©) evaluates 10-year fracture probabilities and can be... Lees meer

        Gepost op 13 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • A randomized, double-blind, placebo-controlled study to evaluate the effects of alendronate on bone mineral density and bone remodelling in perimenopausal women with low bone mineral density.

        J Obstet Gynaecol Can. 2014 Nov;36(11):976-82 Authors: Khan A, Dubois S, Khan AA, Rahman MZ, Khan OA, Syed HT, Derzko C 

        BACKGROUND: Perimenopausal women can experience rapid bone loss at skeletal sites with... Lees meer

        Gepost op 13 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • The microenvironment matters: estrogen deficiency fuels cancer bone metastases.

        Clin Cancer Res. 2014 Jun 1;20(11):2817-9 Authors: Wright LE, Guise TA

        Factors released during osteoclastic bone resorption enhance disseminated breast cancer cell progression by stimulating invasiveness, growth,... Lees meer

        Gepost op 11 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Teriparatide treatment patterns in osteoporosis and subsequent fracture events: a US claims analysis.

        Osteoporos Int. 2015 Jan 8; Authors: Bonafede MM, Shi N, Bower AG, Barron RL, Grauer A, Chandler DB

        INTRODUCTION: The objective of this study was to describe the risk of fragility-related fractures in the... Lees meer

        Gepost op 11 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • Evaluation of the effect of selective serotonin reuptake inhibitors on bone mineral density: an observational cross-sectional study

        Osteoporos Int. 2015 Jan;26(1):273-9. Ak E, Bulut SD, Bulut S, Akdağ HA, Öter GB, Kaya H, Kaya OB, Şengül CB, Kısa C.

        INTRODUCTION:
        The objectives of this study were to evaluate the effect of... Lees meer

        Gepost op 11 January 2015

        Bron: http://www.medworm.com/inde....

      • The effect of supplementation with alkaline potassium salts on bone metabolism: a meta-analysis

        Osteoporos Int. 2015 Jan 9. [Epub ahead of print] Lambert H, Frassetto L, Moore JB, Torgerson D, Gannon R, Burckhardt P, Lanham-New S.

        INTRODUCTION:

        The role of acid-base homeostasis as a... Lees meer

        Gepost op 11 January 2015

        Bron: http://www.medworm.com/inde....

      • Bisphosphonates and their influence on fracture healing: a systematic review

        Osteoporos Int. 2015 Jan 9. [Epub ahead of print] Molvik H1, Khan W.

        INTRODUCTION:

        Bisphosphonates are the most commonly prescribed drugs in patients suffering from... Lees meer

        Gepost op 11 January 2015

        Bron: http://www.medworm.com/inde....

      • μCT-based, in vivo dynamic bone histomorphometry allows 3D evaluation of the early responses of bone resorption and formation to PTH and alendronate combination therapy

        Bone. 2014 Dec 30. [Epub ahead of print]  de Bakker CM, Altman AR, Tseng WJ3, Tribble MB, Li C, Chandra A, Qin L, Sherry Liu X.

        Current osteoporosis treatments improve bone... Lees meer

        Gepost op 11 January 2015

        Bron: http://www.medworm.com/inde....

      • Comparison between different bone treatments on areal bone mineral density (aBMD) and bone microarchitectural texture as assessed by the Trabecular Bone Score (TBS)

        Bone; Published Online: January 05, 2015. S. Di Gregorio, L. Del Rio, J. Rodriguez-Tolra, E. Bonel, M. García, R. Winzenrieth

        Purpose: The objective of the study... Lees meer

        Gepost op 06 January 2015

        Bron: http://www.medworm.com/inde....

      • Eczema associated with osteoporosis-related fractures

        People with the itchy skin condition eczema are more likely than others to have osteoporosis - which may be undiagnosed - and fractures, according to a new analysis.

        Eczema,... Lees meer

        Gepost op 06 January 2015

        Bron: http://www.medworm.com/inde....

      • Successful Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ) Patients with Sitafloxacin: New Strategies for the Treatment of BRONJ.

        Bone. 2014 Dec 27; Authors: Ikeda T, Kuraguchi J, Kogashiwa Y, Yokoi H, Satomi T, Kohno N 

        BRONJ has become a well-known, occasionally severe side effect of bisphosphonate therapy, as well as a clinical... Lees meer

        Gepost op 04 January 2015

        Bron: http://www.ncbi.nlm.nih.gov....

      • The Effect of 6 versus 9 Years of Zoledronic Acid Treatment in Osteoporosis: A Randomized Second Extension to the HORIZON-Pivotal Fracture Trial (PFT).

        J Bone Miner Res. 2014 Dec 26; Authors: Black DM, Reid IR, Cauley JA, Cosman F, Leung PC, Lakatos P, Lippuner K, Cummings SR, Hue TF, Mukhopadhyay A, Tan M, Aftring RP, Eastell R

        While bisphosphonates reduce... Lees meer

        Gepost op 30 December 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • PTH Signaling During Exercise Contributes to Bone Adaptation.

        J Bone Miner Res. 2014 Dec 22; Authors: Gardinier JD, Mohamed F, Kohn DH 

        Improving the structural integrity of bone reduces fracture risk and development of osteoporosis later in life. Exercise can increase... Lees meer

        Gepost op 27 December 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Bone loss drugs may help prevent endometrial cancer

        Sharon Hensley Alford, Ramandeep Rattan, Thomas Buekers, and Adnan Munkarah. Protective effect of bisphosphonates on endometrial cancer incidence in the PLCO data. CANCER, December 2014 DOI: 10.1002/cncr.28952

        New... Lees meer

        Gepost op 27 December 2014

        Bron: http://feeds.sciencedaily.c....

      • Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials.

        Osteoporos Int. 2014 Dec 17; Authors: Huang ZB, Wan SL, Lu YJ, Ning L, Liu C, Fan SW 

        INTRODUCTION: Vitamin K2 has been revealed to be effective in the prevention and treatment of osteoporosis in Japan, which... Lees meer

        Gepost op 22 December 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Associations of Menopausal Vasomotor Symptoms with Fracture Incidence.

        J Clin Endocrinol Metab. 2014 Dec 18;:jc20143062 Authors: Crandall CJ, Aragaki A, Cauley JA, Manson JE, LeBlanc E, Wallace R, Wactawski-Wende J, LaCroix A, O'Sullivan MJ, Vitolins M, Watts NB 

        Context:... Lees meer

        Gepost op 22 December 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Interactions Between Muscle Tissues and Bone Metabolism.

        J Cell Biochem. 2014 Dec 17; Authors: Kawao N, Kaji H 

        Sarcopenia and osteoporosis have recently been noted for their relationship with locomotive syndrome and increased number of older people. Sarcopenia is... Lees meer

        Gepost op 22 December 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Targeted Delivery of Lovastatin and Tocotrienol to Fracture Site Promotes Fracture Healing in Osteoporosis Model: Micro-Computed Tomography and Biomechanical Evaluation.

        PLoS One. 2014;9(12):e115595 Authors: Ibrahim N', Khamis MF, Mod Yunoh MF, Abdullah S, Mohamed N, Shuid AN 

        Osteoporosis is becoming a major health problem that is associated with increased fracture risk.... Lees meer

        Gepost op 22 December 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Too Fit To Fracture: outcomes of a Delphi consensus process on physical activity and exercise recommendations for adults with osteoporosis with or without vertebral fractures

        Osteoporosis International;16 Dec 2014. L. M. Giangregorio, S. McGill, J. D. Wark, J. Laprade, A. Heinonen, M. C. Ashe, N. J. MacIntyre, A. M.... Lees meer

        Gepost op 22 December 2014

        Bron: http://www.medworm.com/inde....

      • Mortality after hip fracture with vertebral compression fracture is poor

        Journal of Bone and Mineral Metabolism; 14 Dec 2014. Norio Imai, Naoto Endo, Tadashi Hoshino, Ken Suda, Dai Miyasaka, Tomoyuki Ito

        Due to the increasing elderly population, the prevalence of osteoporotic... Lees meer

        Gepost op 17 December 2014

        Bron: http://www.medworm.com/inde....

      • Drug may help prevent bone fractures in patients on dialysis

        S. M. Moe, S. Abdalla, G. M. Chertow, P. S. Parfrey, G. A. Block, R. Correa-Rotter, J. Floege, C. A. Herzog, G. M. London, K. W. Mahaffey, D. C. Wheeler, B. Dehmel, W. G. Goodman, T. B. Drueke. Effects of Cinacalcet on... Lees meer

        Gepost op 13 December 2014

        Bron: http://feeds.sciencedaily.c....

      • Increased risk of cardiovascular events in end-stage renal disease patients with osteoporosis: a nationwide population-based cohort study.

        Osteoporos Int. 2014 Dec 10; Authors: Yu TM, Lin CL, Shu KH, Liu YL, Chen CH, Huang ST, Kao CH 

        INTRODUCTION: In this study, we aimed to investigate the risk of cardiovascular disease and mortality in a sample... Lees meer

        Gepost op 13 December 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Choice of osteoporosis guideline has important implications for the treatment decision in elderly women referred to a fall clinic

        Dan. Med. J. 2014; 61: A4980; Thomsen K, Ryg J, Matzen L, Hermann AP, Masud T. 

        INTRODUCTION: Different guidelines are used worldwide to make decisions on treating... Lees meer

        Gepost op 13 December 2014

        Bron: http://www.medworm.com/inde....

      • Effects of raloxifene on bone metabolism in postmenopausal women on chronic hemodialysis

        Clinical and Experimental Nephrology, December 2014. Katsuyuki Nagatoya, Kazuhiko Nishimoto, Nobuhisa Shibahara, Toshikazu Takahashi, Hironori Kanehara, Nobuyuki Ueno, Hideaki Yasuda, Shigeki Okada, Haruhiko Ueda,... Lees meer

        Gepost op 13 December 2014

        Bron: http://www.medworm.com/inde....

      • Association between loop diuretic use and fracture risk

        Osteoporosis International, 10 Dec 2014. F. Xiao, X. Qu, Z. Zhai, C. Jiang, H. Li, X. Liu, Z. Ouyang, D. Gu

        Introduction
        Despite being widely used, there is limited, prospective randomized trial... Lees meer

        Gepost op 13 December 2014

        Bron: http://www.medworm.com/inde....

      • Incident type 2 diabetes and hip fracture risk: a population-based matched cohort study

        Osteoporosis International, 09 Dec 2014; D. Martinez-Laguna, C. Tebe, M. K. Javaid, X. Nogues, N. K. Arden, C. Cooper, A. Diez-Perez, D. Prieto-Alhambra.


        Introduction
        Type 2 diabetes... Lees meer

        Gepost op 13 December 2014

        Bron: http://www.medworm.com/inde....

      • Anabolic bone therapies in 2014: New bone-forming treatments for osteoporosis.

        Nat Rev Endocrinol. 2014 Dec 9; Authors: Papapoulos SE 

        Lees meer

        Gepost op 10 December 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Usefulness of bone density measurement in fallers

        Joint Bone Spine, Volume 81, Issue 5, October 2014, Pages 403-408. Hubert Blain, Yves Rolland, Olivier Beauchet, Cedric Annweiler, Claude-Laurent Benhamou, Athanase Benetos, Gilles Berrut, Maurice Audran, Sauveur... Lees meer

        Gepost op 10 December 2014

        Bron: http://www.medworm.com/inde....

      • Low bone mineral density and fractures in stages 3–5 CKD: an updated systematic review and meta-analysis

        Osteoporosis International 05 dec 2014. R. C. Bucur, D. D. Panjwani, L. Turner, T. Rader, S. L. West, S. A. Jamal

         

        Introduction: Lees meer

        Gepost op 07 December 2014

        Bron: http://www.medworm.com/inde....

      • Bisphosphonate Prescriptions in Men With Androgen Deprivation Therapy Use

        JAMA. 2014;312(21):2285-2286. Husayn Gulamhusein, Lingsong Yun, Angela M. Cheung, Rinku Sutradhar, Lawrence Paszat, Padraig Warde, Shabby M. H. Alibhai

        Androgen deprivation... Lees meer

        Gepost op 07 December 2014

        Bron: http://www.medworm.com/inde....

      • Statins Won't Help Protect Bones, Study Finds

        The cholesterol-lowering drugs known as statins have been touted by some as capable of reducing the risk for broken bones. But, it appears that's not the case, a new study finds.

        In the study, almost 18,000... Lees meer

        Gepost op 04 December 2014

        Bron: http://www.webmd.com/osteop....

      • Alternative treatments for oral bisphosphonate-related osteonecrosis of the jaws: a pilot study comparing fibrin rich in growth factors and teriparatide.

        Med Oral Patol Oral Cir Bucal. 2014 Jul 1;19(4):e320-6 . Pelaz A, Junquera L, Gallego L, García-Consuegra L, Junquera S, Gómez C.


        OBJECTIVE: The aim of this study is to describe and... Lees meer

        Gepost op 04 December 2014

        Bron: http://www.medworm.com/inde....

      • Vertebral fractures on routine chest computed tomography: relation with arterial calcifications and future cardiovascular events

        The International Journal of Cardiovascular Imaging 02 Dec 2014. Constantinus F. Buckens, Pim A. de Jong, Helena M. Verkooijen, Harald J. Verhaar, Willem P. Mali, Yolanda van der Graaf, PROVISIE  study... Lees meer

        Gepost op 04 December 2014

        Bron: http://www.medworm.com/inde....

      • Widely used osteoporosis drugs may prevent breast, lung and colon cancers

        The most commonly used medications for osteoporosis worldwide, bisphosphonates, may also prevent certain kinds of lung, breast and colon cancers, according to two studies led by researchers at the Icahn School of Medicine at... Lees meer

        Gepost op 04 December 2014

        Bron: http://www.medworm.com/inde....

      • Eli Lilly buys rights to osteoporosis skin patch

        Eli Lilly and Co. has bought the rights to develop an osteoporosis medicine that's delivered through a skin patch. The exclusive development agreement could lead to a notable advance in osteoporosis treatment if it... Lees meer

        Gepost op 04 December 2014

        Bron: http://news.google.com/news....

      • Odanacatib for the treatment of postmenopausal osteoporosis: development history and design and participant characteristics of LOFT, the Long-Term Odanacatib Fracture Trial

        Osteoporosis International, nov 2014. Bone H.G. et al.

        Introduction: Odanacatib (ODN) is a selective cathepsin K inhibitor being evaluated for the treatment of osteoporosis. In a phase 2 trial, ODN 50 mg once... Lees meer

        Gepost op 04 December 2014

        Bron: http://www.medworm.com/inde....

      • Increasing Hip Fractures in Patients Receiving Hemodialysis and Peritoneal Dialysis.

        Am J Nephrol. 2014 Nov 26;40(5):451-457 Authors: Mathew AT, Hazzan A, Jhaveri KD, Block GA, Chidella S, Rosen L, Wagner J, Fishbane S

        Background/Aims: Dialysis patients are at increased risk for hip fractures.... Lees meer

        Gepost op 29 November 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Prolonged risk of subtrochanteric and diaphyseal femur fractures after discontinuing alendronate treatment: A nationwide nested case-control study in Taiwan

        Conclusion: Discontinuation of alendronate therapy did not reduce the risk of subtrochanteric femoral fractures until it was discontinued for >5 years. In conclusion, alendronate use significantly increased the risk... Lees meer

        Gepost op 29 November 2014

        Bron: http://www.medworm.com/inde....

      • National Osteoporosis Society Practical Clinical Guideline on Vitamin D and Bone Health

        R.M. Francis, T.J. Aspray, C.E. Bowring, W.D. Fraser, N.J. Gittoes, M.K. Javaid, H.M. Macdonald, S. Patel, P.L. Selby, N. Tanna. Maturitas Lees meer

        Gepost op 29 November 2014

        Bron: http://www.medworm.com/inde....

      • Diagnosis and Management of Osteonecrosis of the Jaw: A Systematic Review and International Consensus.

        J Bone Miner Res. 2014 Nov 21; Authors: Khan A, Morrison A, Hanley D, Felsenberg D, McCauley L, O'Ryan F, Reid I, Ruggiero S, Taguchi A, Tetradis S, Watts N, Brandi M, Peters E, Guise T, Eastell R, Cheung A, Morin S,... Lees meer

        Gepost op 23 November 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw--2014 update.

        J Oral Maxillofac Surg. 2014 Oct;72(10):1938-56 Authors: Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B, O'Ryan F, American Association of Oral and Maxillofacial Surgeons 

        Strategies... Lees meer

        Gepost op 16 November 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Effects of Abaloparatide, a Human Parathyroid Hormone-related Peptide Analog, on Bone Mineral Density in Postmenopausal Women with Osteoporosis.

        J Clin Endocrinol Metab. 2014 Nov 13;:jc20143718 Authors: Leder BZ, O'Dea LS, Zanchetta JR, Kumar P, Banks K, McKay K, Lyttle CR, Hattersley G

        CONTEXT: Abaloparatide is a novel synthetic peptide analog of... Lees meer

        Gepost op 16 November 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Self-perceived facture risk: factors underlying women's perception of risk for osteoporotic fractures: the Risk-Stratified Osteoporosis Strategy Evaluation study (ROSE).

        Osteoporos Int. 2014 Nov 1; Authors: Rothmann MJ, Ammentorp J, Bech M, Gram J, Rasmussen OW, Barkmann R, Glüer CC, Hermann AP

        INTRODUCTION: The aim of this study is to investigate women's self-perceived... Lees meer

        Gepost op 11 November 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Risk of Subsequent Fractures and Mortality in Elderly Women and Men With Fragility Fractures With and Without Osteoporotic Bone Density: The Dubbo Osteoporosis Epidemiology Study.

        J Bone Miner Res. 2014 Oct 31; Authors: Bliuc D, Alarkawi D, Nguyen TV, Eisman JA, Center JR 

        CONTEXT: Half of fragility fractures occur in individuals with non-osteoporotic BMD (BMD T-score >-2.5), however... Lees meer

        Gepost op 11 November 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Minimal-trauma fracture in women with breast cancer surviving for at least 5 years from diagnosis.

        Osteoporos Int. 2014 Oct 31; Authors: Robinson PJ, Bell RJ, Zecena Morales CS, Fradkin P, Davis SR 

        INTRODUCTION: We have investigated the self-reported frequency and pattern of minimal-trauma fracture (MTF)... Lees meer

        Gepost op 11 November 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Bone drug should be seen in a new light for its anti-cancer properties

        Researchers have shown why calcium-binding drugs commonly used to treat people with osteoporosis, or with late-stage cancers that have spread to bone, may also benefit patients with tumors outside the skeleton, including... Lees meer

        Gepost op 11 November 2014

        Bron: http://feeds.sciencedaily.c....

      • A Systematic Review of Cost-Effectiveness Analyses of Drugs for Postmenopausal Osteoporosis.

        Pharmacoeconomics. 2014 Nov 7; Authors: Hiligsmann M, Evers SM, Ben Sedrine W, Kanis JA, Ramaekers B, Reginster JY, Silverman S, Wyers CE, Boonen A Abstract

        BACKGROUND: Given the... Lees meer

        Gepost op 11 November 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Novel approaches to the treatment of osteoporosis

        Best Practice & Research Clinical Endocrinology & Metabolism Author(s): Natasha M. Appelman-Dijkstra , Socrates E. Papapoulos

        Despite the availability of efficacious treatments for fracture reduction in... Lees meer

        Gepost op 11 November 2014

        Bron: http://www.medworm.com/inde....

      • Milk may be linked to bone fractures and early death

        Michaëlsson K, Wolk A, Langenskiöld S, et al. Milk intake and risk of mortality and fractures in women and men: cohort studies. British Medical Journal. Published online October 28 2014

        Conclusion: This... Lees meer

        Gepost op 31 October 2014

        Bron: http://www.medworm.com/inde....

      • Baseline age and time to major fracture in younger postmenopausal women.

        Menopause. 2014 Oct 27; Authors: Gourlay ML, Overman RA, Fine JP, Ensrud KE, Crandall CJ, Gass ML, Robbins J, Johnson KC, LeBlanc ES, Womack CR, Schousboe JT, LaCroix AZ, for the Women’s Health Initiative... Lees meer

        Gepost op 29 October 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Oral bisphosphonates and upper gastrointestinal toxicity: a study of cancer and early signals of esophageal injury.

        Osteoporos Int. 2014 Oct 28; Authors: Morden NE, Munson JC, Smith J, Mackenzie TA, Liu SK, Tosteson AN

        We evaluated the association between bisphosphonate use and (1) upper gastrointestinal cancer, (2) upper... Lees meer

        Gepost op 29 October 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Latest bone research abstracts ASBMR summarized in slides and videos

        (International Osteoporosis Foundation) This educational slide deck highlights 60 original scientific abstracts presented at the Annual Meeting of the American Society for Bone and Mineral Research in September... Lees meer

        Gepost op 29 October 2014

        Bron: http://www.medworm.com/inde....

      • Osteoporosis screening guidelines miss many younger post-menopausal women

        Bron: Los Angeles Health Sciences

        To reduce the risk of bone fractures and the complications arising from them, the United States Preventive Services Task force (USPSTF) recommends... Lees meer

        Gepost op 25 October 2014

        Bron: http://www.medworm.com/inde....

      • United States Adults Meeting 2010 American College of Rheumatology Criteria for Treatment and Prevention of Glucocorticoid‐Induced Osteoporosis

        Robert A. Overman, Joshua C. Toliver, Jun-Yen Yeh, Margaret L. Gourlay and Chad L. Deal. Arthritis Care & Research
        Volume 66, Issue 11, pages 1644–1652, November 2014

        Lees meer

        Gepost op 25 October 2014

        Bron: http://www.medworm.com/inde....

      • Bisphosphonates Can Be Started Early After Surgery for Fracture

        Bisphosphonate therapy for osteoporosis does not appear to interfere with healing after surgery for bone fractures, according to new research.  (Source: Medscape Orthopaedics Headlines)

        Lees meer

        Gepost op 25 October 2014

        Bron: http://www.medworm.com/inde....

      • Comparative Effects of Teriparatide, Denosumab, and Combination Therapy on Peripheral Compartmental Bone Density, Microarchitecture, and Estimated Strength: the DATA‐HRpQCT Study

        Tai JN et al. J Bone Miner Res. 2014

        Combined teriparatide and denosumab increases spine and hip bone mineral density more than either drug alone. The effect of this combination on skeletal microstructure and... Lees meer

        Gepost op 22 October 2014

        Bron: http://www.medworm.com/inde....

      • Cortical Thickness of the Femur and Long‐term Bisphosphonate Use

        Niimi R et al. J Bone Miner Res. 2014 

        Femoral cortical thickening has been mentioned in reports of atypical subtrochanteric/femoral shaft (ST/FS) fractures, which are... Lees meer

        Gepost op 22 October 2014

        Bron: http://www.medworm.com/inde....

      • Relationship Between Pre‐treatment Rate of Bone Loss and Bone Density Response to Once‐Yearly ZOL: HORIZON‐PFT Extension Study

        Eastell R et al. J Clin Endocrinol Metab 2014

        Several studies have shown that high bone turnover is associated with 1) greater rates of bone loss and 2) greater BMD response to anti‐resorptive therapy in... Lees meer

        Gepost op 22 October 2014

        Bron: http://www.medworm.com/inde....

      • Comparison of Fracture Risk Prediction by the US Preventive Services Task Force Strategy and Two Alternative Strategies in Women 50-64 Years Old in the Women's Health Initiative.

        Crandall CJ et al. J Clin Endocrinol Metab 2014, oct 16

        Conclusions: Our findings do not support use of the USPSTF strategy, Osteoporosis Self-Assessment Tool, or SCORE to identify younger... Lees meer

        Gepost op 22 October 2014

        Bron: http://www.medworm.com/inde....

      • The risk of major and any (non-hip) fragility fracture after hip fracture in the United Kingdom: 2000–2010

        Gibson-Smith D et al. Osteoporos Int. 2014 nov

        Introduction: Hip fractures are associated with subsequent fractures, particularly in the year following initial fracture. Age-adjusted hip fracture rates have... Lees meer

        Gepost op 22 October 2014

        Bron: http://www.medworm.com/inde....

      • Management of osteoporosis of the oldest old

        Rizzoli R et al. Osteoporos Int. 2014 nov

        Introduction: This consensus article reviews the therapeutic strategies and management options for the treatment of osteoporosis of the oldest old. This vulnerable segment... Lees meer

        Gepost op 22 October 2014

        Bron: http://www.medworm.com/inde....

      • A randomized, double‐blind phase 2 clinical trial of blosozumab, a sclerostin antibody, in postmenopausal women with low bone mineral density

        Recker R et al. J Bone Miner Res 2014

        In conclusion, treatment of postmenopausal women with an antibody targeted against sclerostin resulted in substantial increases in spine and hip BMD. These... Lees meer

        Gepost op 22 October 2014

        Bron: http://www.medworm.com/inde....

      • Denosumab Rapidly Increases Cortical Bone in Key Locations of the Femur: A 3D Bone Mapping Study in Women with Osteoporosis

        Poole KES et al. J Bone Miner Res 2014

        The aim of this study was to examine the effects of denosumab versus placebo on cortical bone using clinical CT. We used cortical... Lees meer

        Gepost op 22 October 2014

        Bron: http://www.medworm.com/inde....

      • Is There Enough Evidence to Use Bisphosphonates in HIV-Infected Patients? A Systematic Review and Meta-analysis.

        In conclusion, administration of oral and intravenous bisphosphonates was associated with increased bone mineral density at the lumbar spine and total hip over two years in HIV-positive patients. However, none of the... Lees meer

        Gepost op 19 October 2014

        Bron: http://www.medworm.com/inde....

      • When it Comes to Bone Health Males are the Weaker Sex

        Alarming new data published today by the International Osteoporosis Foundation (IOF), shows that one-third of all hip fractures worldwide occur in men, with mortality rates as high as 37% in the first year following... Lees meer

        Gepost op 19 October 2014

        Bron: http://www.medworm.com/inde....

      • Residual effect after oral bisphosphonate treatment and healthy adherer effects—the Swedish adherence register analysis (SARA)

        O. Strom et al. Osteoporosis International

        Little is known of the effect of alendronate and risedronate on osteoporotic fractures after discontinuation of therapy. We found that time on treatment was significantly... Lees meer

        Gepost op 19 October 2014

        Bron: http://www.medworm.com/inde....

      • Effects of long-term alendronate treatment on postmenopausal osteoporosis bone material properties

         N. Hassler et al. Osteoporosis International

        Raman microspectroscopic analysis of iliac crest from patients that were treated with alendronate (ALN) for 10 years revealed minimal, transient... Lees meer

        Gepost op 19 October 2014

        Bron: http://www.medworm.com/inde....

      • Effect of Oral Bisphosphonates for Osteoporosis on Development of Skeletal Metastases in Women With Breast Cancer: Results From a Pharmaco-epidemiological Study.

        J Natl Cancer Inst. 2014 Nov;106(11) Authors: Kremer R, Gagnon B, Meguerditchian AN, Nadeau L, Mayo N

        BACKGROUND: Treatment with bisphosphonates in women with breast cancer and established bone metastasis delays... Lees meer

        Gepost op 07 October 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • 'Unsung' cells double the benefits of a new osteoporosis drug

        Experiments in mice with a bone disorder similar to that in women after menopause show that a scientifically overlooked group of cells are likely crucial to the process of bone loss caused by the disorder, according to Johns... Lees meer

        Gepost op 07 October 2014

        Bron: http://www.medworm.com/inde....

      • The Auckland calcium study: 5-year post-trial follow-up.

        Osteoporos Int. 2014 Jan;25(1):297-304 Authors: Radford LT, Bolland MJ, Mason B, Horne A, Gamble GD, Grey A, Reid IR

        INTRODUCTION: The Auckland calcium study was a 5-year randomised controlled trial of 1 g/day... Lees meer

        Gepost op 04 October 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Mild morphometric vertebral fractures predict vertebral fractures but not non-vertebral fractures.

        Osteoporos Int. 2014 Jan;25(1):235-41 Authors: Johansson H, Odén A, McCloskey EV, Kanis JA

        INTRODUCTION: A prior vertebral fracture is a risk factor for future fracture that is commonly used as an... Lees meer

        Gepost op 04 October 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • An algorithm using the early changes in PINP to predict the future BMD response for patients treated with daily teriparatide.

        Osteoporos Int. 2014 Jan;25(1):377-84 Authors: Niimi R, Kono T, Nishihara A, Hasegawa M, Matsumine A, Nakamura T, Kono T, Sudo A

        INTRODUCTION: An algorithm using PINP is provided in osteoporotic patients with... Lees meer

        Gepost op 04 October 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Fracture prevention in patients with cognitive impairment presenting with a hip fracture: secondary analysis of data from the HORIZON Recurrent Fracture Trial.

        Osteoporos Int. 2014 Jan;25(1):77-83 Authors: Prieto-Alhambra D, Judge A, Arden NK, Cooper C, Lyles KW, Javaid MK

        INTRODUCTION: We tested whether the effects of zoledronic acid (Zol) on re-fracture and mortality... Lees meer

        Gepost op 04 October 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Switch patterns of osteoporosis medication and its impact on persistence among postmenopausal women in the UK General Practice Research Database

        Conclusion: Among women who switch their initial medication, even though switching to the second medication improves persistence during the initial therapy, persistence on the second and subsequent therapies remains... Lees meer

        Gepost op 04 October 2014

        Bron: http://www.medworm.com/inde....

      • Effect of Oral Bisphosphonates for Osteoporosis on Development of Skeletal Metastases in Women With Breast Cancer: Results From a Pharmaco-epidemiological Study

        Conclusion: Low-dose oral bisphosphonates administered for prevention or treatment of postmenopausal osteoporosis were associated with lower risk of skeletal metastasis in patients with early- or more advanced-stage breast... Lees meer

        Gepost op 04 October 2014

        Bron: http://www.medworm.com/inde....

      • There is Low Clinical Relevance of a Prevalent Vertebral Fracture in Old Men - the MrOs Sweden Study.

        Spine J. 2014 Sep 24; Authors: Kherad M, Rosengren BE, Hasserius R, Nilsson JA, Redlund-Johnell I, Ohlsson C, Ljunggren O, Lorentzon M, Mellström D, Karlsson MK 

        INTRODUCTION: The epidemiology, the... Lees meer

        Gepost op 01 October 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Managing osteoporosis with FRAX® in Australia: proposed new treatment thresholds from the 45&Up Study cohort.

        Bone. 2014 Sep 24; Authors: Chen JS, Simpson JM, Blyth FM, March LM 

        INTRODUCTION: Many people at high risk of fractures are not following traditional guidelines and not being recommended for intervention.... Lees meer

        Gepost op 01 October 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Timing of the initiation of bisphosphonates after surgery for fracture healing: a systematic review and meta-analysis of randomized controlled trials.

        Osteoporos Int. 2014 Sep 30; Authors: Li YT, Cai HF, Zhang ZL 

        We performed a systematic review and meta-analysis of randomized clinical trials. Early administration of bisphosphonates (BPs) after surgery did... Lees meer

        Gepost op 01 October 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • A cross-sectional study to examine the correlation between serum TSH levels and the osteoporosis of the lumbar spine in healthy women with normal thyroid function.

        Osteoporos Int. 2014 Sep 25; Authors: Noh HM, Park YS, Lee J, Lee W

        INTRODUCTION: We aimed to examine the association between serum thyroid-stimulating hormone (TSH) levels and osteoporosis of the lumbar spine in... Lees meer

        Gepost op 28 September 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • How to predict fragility fracture beyond ten years? The OFELY study.

        J Clin Endocrinol Metab. 2014 Sep 24;:jc20142601 Authors: Sornay-Rendu E, Duboeuf F, Boutroy S, Chapurlat R

        Context: Low bone mineral density (BMD) is a major determinant of fragility fractures (Fx) but its very... Lees meer

        Gepost op 28 September 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Predictors of re-fracture amongst patients managed within a secondary fracture prevention program: a 7-year prospective study

        Conclusions: Amongst patients managed within a dedicated SFP programme, poor compliance, multiple co-morbidities, corticosteroid therapy, low hip BMD or low body weight are all associated with increased risk of re-fracture.... Lees meer

        Gepost op 28 September 2014

        Bron: http://www.medworm.com/inde....

      • Distribution of vertebral fractures varies among patients according to hip fracture type

        Conclusion: The distribution of vertebral fractures among patients with subcapital fractures differed from the other fracture groups, which may indicate that subcapital fractures and some lumbar fractures have a different... Lees meer

        Gepost op 28 September 2014

        Bron: http://www.medworm.com/inde....

      • Ulnar fractures with bisphosphonate therapy: a systematic review of published case reports

        Conclusion: Ulnar fractures in patients with bisphosphonate therapy demonstrate features similar to those described for atypical femoral fractures, suggesting that these fractures could also possibly be due to... Lees meer

        Gepost op 28 September 2014

        Bron: http://www.medworm.com/inde....

      • Percutaneous vertebroplasty compared with conservative treatment in patients with chronic painful osteoporotic spinal fractures.

        J Clin Neurosci. 2014 Mar;21(3):473-7 Authors: Chen D, An ZQ, Song S, Tang JF, Qin H 

        The efficacy of percutaneous vertebroplasty (PVP) for patients with chronic painful osteoporotic compression fractures... Lees meer

        Gepost op 24 September 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Persistence at 12 months with denosumab in postmenopausal women with osteoporosis: interim results from a prospective observational study.

        Osteoporos Int. 2014 Sep 19; Authors: Silverman SL, Siris E, Kendler DL, Belazi D, Brown JP, Gold DT, Lewiecki EM, Papaioannou A, Simonelli C, Ferreira I, Balasubramanian A, Dakin P, Ho P, Siddhanti S, Stolshek B, Recknor... Lees meer

        Gepost op 24 September 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Proton-pump inhibitor use and hip fractures in men: a population-based case-control study.

        Ann Epidemiol. 2014 Apr;24(4):286-90 Authors: Adams AL, Black MH, Zhang JL, Shi JM, Jacobsen SJ

        PURPOSE: To estimate the association between proton-pump inhibitor (PPI) use and hip fracture. METHODS: We conducted a... Lees meer

        Gepost op 24 September 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Diagnosis and treatment of pediatric osteoporosis.

        Curr Opin Endocrinol Diabetes Obes. 2014 Sep 17; Authors: Bachrach LK 

        PURPOSE OF REVIEW: Progress toward identifying and treating disorders of bone fragility in pediatric patients has been considerable in... Lees meer

        Gepost op 20 September 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Glucocorticoids in Early Rheumatoid Arthritis: Are the Benefits of Joint-Sparing Effects Offset by the Adverse Effect of Osteoporosis? The Effects on Bone in the Utrecht Study and the CAMERA-II Study.

        Neuroimmunomodulation. 2014 Sep 12;22(1-2):66-71 Authors: Jacobs JW, Bijlsma JW, van Laar JM 

        This paper reviews the clinical effects on bone of 10 mg of prednisone daily in early rheumatoid arthritis, given... Lees meer

        Gepost op 20 September 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Healing of bisphosphonate-associated atypical femoral fractures in patients with osteoporosis: a comparison between treatment with and without teriparatide.

        J Bone Miner Metab. 2014 Sep 17; Authors: Miyakoshi N, Aizawa T, Sasaki S, Ando S, Maekawa S, Aonuma H, Tsuchie H, Sasaki H, Kasukawa Y, Shimada Y 

        Atypical femoral fracture (AFF) often appears with... Lees meer

        Gepost op 20 September 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Magnitude of fragility fracture risk in the very old-are we meeting their needs? The Newcastle 85+ Study.

        Osteoporos Int. 2014 Sep 16; Authors: Duncan R, Francis RM, Jagger C, Kingston A, McCloskey E, Collerton J, Robinson L, Kirkwood TB, Birrell F 

        INTRODUCTION: Fragility fractures are a major cause of excess... Lees meer

        Gepost op 18 September 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Merck Announces Data from Pivotal Phase 3 Fracture Outcomes Study for Odanacatib, an Investigational Oral, Once-Weekly Treatment for Osteoporosis

        Merck, known as MSD outside the United States and Canada, today announced data from the pivotal Phase 3 fracture outcomes study for odanacatib in postmenopausal women with osteoporosis. Odanacatib is Merck’s... Lees meer

        Gepost op 18 September 2014

        Bron: http://www.medworm.com/inde....

      • Relationship Between Pre-treatment Rate of Bone Loss and Bone Density Response to Once-Yearly ZOL: HORIZON-PFT Extension Study.

        J Bone Miner Res. 2014 Sep 11; Authors: Eastell R, Boonen S, Cosman F, Reid IR, Palermo L, Cummings SR, Black DM 

        Several studies have shown that high bone turnover is associated with 1) greater rates of bone... Lees meer

        Gepost op 14 September 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Coronary microvascular endothelial dysfunction is an independent predictor of development of osteoporosis in postmenopausal women.

        Vasc Health Risk Manag. 2014;10:533-8 Authors: Prasad M, Reriani M, Khosla S, Gössl M, Lennon R, Gulati R, Prasad A, Lerman LO, Lerman A 

        BACKGROUND: A growing body of evidence links coronary artery... Lees meer

        Gepost op 14 September 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Identifying Atypical Femoral Fractures-A Retrospective Review.

        Calcif Tissue Int. 2014 Sep 11; Authors: Juby AG, Crowther S, Cree M 

        Subtrochanteric atypical femoral fractures (AFFs) have been reported in patients on osteoporosis therapy (bisphosphonates and denosumab).... Lees meer

        Gepost op 14 September 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Comparative Effectiveness of Pharmacologic Treatments to Prevent Fractures: An Updated Systematic Review.

        Ann Intern Med. 2014 Sep 9; Authors: Crandall CJ, Newberry SJ, Diamant A, Lim YW, Gellad WF, Booth MJ, Motala A, Shekelle PG 

        Background: Osteoporosis is a major contributor to the propensity to fracture among... Lees meer

        Gepost op 12 September 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Goal-directed treatment of osteoporosis in Europe.

        Osteoporos Int. 2014 Sep 9; Authors: Kanis JA, McCloskey E, Branco J, Brandi ML, Dennison E, Devogelaer JP, Ferrari S, Kaufman JM, Papapoulos S, Reginster JY, Rizzoli R

        INTRODUCTION: Treat-to-target is a strategy... Lees meer

        Gepost op 12 September 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Effect of simvastatin and atorvastatin on serum vitamin d and bone mineral density in hypercholesterolemic patients: a cross-sectional study.

        J Osteoporos. 2014;2014:468397 Authors: Thabit A, Alhifany A, Alsheikh R, Namnqani S, Al-Mohammadi A, Elmorsy S, Qari M, Ardawi M 

        Background. Besides lipid-lowering effect of statins, they have been shown to... Lees meer

        Gepost op 12 September 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • A randomized, double-blind phase 2 clinical trial of blosozumab, a sclerostin antibody, in postmenopausal women with low bone mineral density.

        J Bone Miner Res. 2014 Sep 5; Authors: Recker R, Benson C, Matsumoto T, Bolognese M, Robins D, Alam J, Chiang AY, Hu L, Krege JH, Sowa H, Mitlak B, Myers S 

        Sclerostin, a SOST protein secreted by osteocytes,... Lees meer

        Gepost op 12 September 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Are patterns of bone loss in anorexic and postmenopausal women similar? Preliminary results using high resolution peripheral computed tomography.

        Bone. 2014 Jan;58:146-50 Authors: Milos G, Häuselmann HJ, Krieg MA, Rüegsegger P, Gallo LM

        This study intended to compare bone density and architecture in three groups of women: young women with anorexia... Lees meer

        Gepost op 06 September 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Prevalent vertebral fractures on chest CT: higher risk for future hip fracture.

        J Bone Miner Res. 2014 Feb;29(2):392-8 Authors: Buckens CF, de Jong PA, Mali WP, Verhaar HJ, van der Graaf Y, Verkooijen HM 

        Subclinical or undiagnosed vertebral fractures on routine chest computed tomography... Lees meer

        Gepost op 06 September 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Intravenous contrast injection significantly affects bone mineral density measured on CT.

        Eur Radiol. 2014 Sep 5; Authors: Pompe E, Willemink MJ, Dijkhuis GR, Verhaar HJ, Hoesein FA, de Jong PA

        OBJECTIVE: The objective is to evaluate the effect of intravenous contrast media on bone mineral density (BMD)... Lees meer

        Gepost op 06 September 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Impact of Femoral Neck and Lumbar Spine BMD Discordances on FRAX Probabilities in Women: A Meta-analysis of International Cohorts.

        Calcif Tissue Int. 2014 Sep 4; Authors: Johansson H, Kanis JA, Odén A, Leslie WD, Fujiwara S, Glüer CC, Kroger H, Lacroix AZ, Lau E, Melton LJ, Eisman JA, O'Neill TW, Goltzman D, Reid DM, McCloskey... Lees meer

        Gepost op 06 September 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Evaluation of the effect of selective serotonin reuptake inhibitors on bone mineral density: an observational cross-sectional study.

        Osteoporos Int. 2014 Sep 4; Authors: Ak E, Bulut SD, Bulut S, Akdağ HA, Oter GB, Kaya H, Kaya OB, Sengül CB, Kısa C

        Sixty patients diagnosed with generalized anxiety disorder and treated with either... Lees meer

        Gepost op 06 September 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Clinician's Guide to Prevention and Treatment of Osteoporosis.

        Osteoporos Int. 2014 Aug 15; Authors: Cosman F, de Beur SJ, LeBoff MS, Lewiecki EM, Tanner B, Randall S, Lindsay R

        The Clinician's Guide to Prevention and Treatment of Osteoporosis was developed by an expert... Lees meer

        Gepost op 06 September 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Acute effect of zoledronic acid on the risk of cardiac dysrhythmias.

        Intern Emerg Med. 2014 Sep 5; Authors: Cipriani C, Castro C, Curione M, Piemonte S, Biamonte F, Savoriti C, Pepe J, De Lucia F, Clementelli C, Nieddu L, Minisola S 

        There have been recent concerns regarding... Lees meer

        Gepost op 06 September 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Oral Bone Drug Fails in Osteoporosis

        Postmenopausal women with osteoporosis treated with an oral calcium-sensing receptor antagonist showed increases in bone formation markers but it failed to boost bone mineral density (BMD) in a phase II dose-ranging study.... Lees meer

        Gepost op 06 September 2014

        Bron: http://news.google.com/news....

      • Osteoporosis is associated with antiepileptic drugs: a population-based study.

        Epileptic Disord. 2014 Aug 28; Authors: Wu FJ, Sheu SY, Lin HC

        Controversy remains regarding the risk of bone abnormalities due to enzyme-inducing antiepileptic drugs (EIAEDs) and non-enzyme-inducing antiepileptic... Lees meer

        Gepost op 31 August 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Effect of GH/IGF-1 on Bone Metabolism and Osteoporsosis.

        Int J Endocrinol. 2014;2014:235060 Authors: Locatelli V, Bianchi VE

        Background. Growth hormone (GH) and insulin-like growth factor (IGF-1) are fundamental in skeletal growth during puberty and bone health... Lees meer

        Gepost op 28 August 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Do cadmium, lead, and aluminum in drinking water increase the risk of hip fractures? A NOREPOS study.

        Biol Trace Elem Res. 2014 Jan;157(1):14-23 Authors: Dahl C, Søgaard AJ, Tell GS, Flaten TP, Hongve D, Omsland TK, Holvik K, Meyer HE, Aamodt G, Norwegian Epidemiologic Osteoporosis Study (NOREPOS) Core Research... Lees meer

        Gepost op 28 August 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Is vertebroplasty a risk factor for subsequent vertebral fracture, meta-analysis of published evidence?

        Osteoporos Int. 2014 Aug 23; Authors: Han SL, Wan SL, Li QT, Xu DT, Zang HM, Chen NJ, Chen LY, Zhang WP, Luan C, Yang F, Xu ZW

        INTRODUCTION: Vertebroplasty has been implicated in significant changes in vertebral... Lees meer

        Gepost op 28 August 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • A Population-Based Nested Case-Control Study: The Use of 5-Alpha-Reductase Inhibitors and the Increased Risk of Osteoporosis Diagnosis in Patients With Benign Prostate Hyperplasia.

        Clin Endocrinol (Oxf). 2014 Aug 27; Authors: Lin WL, Hsieh YW, Lin CL, Sung FC, Wu CH, Kao CH

        BACKGROUND: 5-alpha-reductase inhibitors (5ARIs) are the potent androgen responsible for the development and enlargement... Lees meer

        Gepost op 28 August 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Cortical Thickness of the Femur and Long-term Bisphosphonate Use.

        J Bone Miner Res. 2014 Aug 22; Authors: Niimi R, Kono T, Nishihara A, Hasegawa M, Matsumine A, Kono T, Sudo A

        Femoral cortical thickening has been mentioned in reports of atypical subtrochanteric/femoral shaft... Lees meer

        Gepost op 28 August 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Bone Mineral Density Changes Among Women Initiating Proton Pump Inhibitors or H2 Receptor Antagonists: A SWAN Cohort Study.

        J Bone Miner Res. 2014 Aug 22; Authors: Solomon DH, Diem SJ, Ruppert K, Lian Y, Liu CC, Wohlfart A, Greendale GA, Finkelstein JS

        Proton pump inhibitors (PPIs) have been associated with diminished bone mineral... Lees meer

        Gepost op 28 August 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • National Osteoporosis Society Vitamin D Guideline Summary

        The National Osteoporosis Society (NOS) published its document, Vitamin D and Bone Health: A Practical Clinical Guideline for Patient Management, in 2013 as a practical clinical guideline on the management of vitamin D... Lees meer

        Gepost op 28 August 2014

        Bron: http://www.medworm.com/inde....

      • Increasing rates of pelvic fractures among older adults: The Netherlands, 1986-2011

        Conclusion: absolute numbers and incidence rates of pelvic fractures are increasing among the older Dutch population. Considering the fact the general population is growing older, an increasing number of elderly suffer from... Lees meer

        Gepost op 28 August 2014

        Bron: http://www.medworm.com/inde....

      • Balance training with multi-task exercises improves fall-related self-efficacy, gait, balance performance and physical function in older adults with osteoporosis: a randomized controlled trial.

        Clin Rehabil. 2014 Aug 20; Authors: Halvarsson A, Franzén E, Ståhle A

        OBJECTIVE: To evaluate the effects of a balance training program including dual- and multi-task exercises on fall-related... Lees meer

        Gepost op 24 August 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Genetics of osteoporosis.

        Biochem Biophys Res Commun. 2014 Aug 16; Authors: Urano T, Inoue S

        Osteoporosis is a skeletal disease characterized by low bone mineral density (BMD) and microarchitectural deterioration of bone tissue, which... Lees meer

        Gepost op 24 August 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Serum levels of 25-hydroxyvitamin D and the occurrence of musculoskeletal diseases: a 3-year follow-up to the road study.

        Osteoporos Int. 2014 Aug 20; Authors: Yoshimura N, Muraki S, Oka H, Nakamura K, Kawaguchi H, Tanaka S, Akune T 

        INTRODUCTION: The aim of this study is to clarify the association between serum 25-hydroxyvitamin... Lees meer

        Gepost op 24 August 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Heart failure: BMD a predictor of incident heart failure

        Nature Reviews Cardiology 11, 497 (2014). doi:10.1038/nrcardio.2014.108 Author: Tim Geach

        Heart failure is a known risk factor for osteoporosis. In a new paper, investigators now identify an independent association... Lees meer

        Gepost op 24 August 2014

        Bron: http://www.medworm.com/inde....

      • Duration of antiresorptive effects of low-dose zoledronate in osteopenic postmenopausal women: a randomized, placebo-controlled trial.

         J Bone Miner Res. 2014 Jan;29(1):166-72 Authors: Grey A, Bolland M, Mihov B, Wong S, Horne A, Gamble G, Reid IR 

        Annual intravenous administration of 5 mg zoledronate decreases fracture risk, but... Lees meer

        Gepost op 20 August 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Effects of atorvastatin on bone mineral density (BMD) and bone metabolism in elderly males with osteopenia and mild dyslipidemia: A 1-year randomized trial.

        Arch Gerontol Geriatr. 2014 Jul 12; Authors: Chen ZG, Cai HJ, Jin X, Lu JH, Wang J, Fang NY 

        We explored the effects of atorvastatin on BMD and biochemical markers of bone metabolism in a 1-year, prospective,... Lees meer

        Gepost op 20 August 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Compromised peak bone mass in patients with inflammatory bowel disease--a prospective study.

        J Pediatr. 2014 Jun;164(6):1436-43.e1 Authors: Laakso S, Valta H, Verkasalo M, Toiviainen-Salo S, Mäkitie O 

        OBJECTIVE: To evaluate peak bone mass attainment in children and adolescents with inflammatory... Lees meer

        Gepost op 20 August 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Post-fracture pharmacotherapy for women with osteoporotic fracture: analysis of a managed care population in the USA.

        Osteoporos Int. 2014 Aug 12; Authors: Wilk A, Sajjan S, Modi A, Fan CP, Mavros P 

        INTRODUCTION: Pharmacologic therapy is recommended after osteoporotic fracture to reduce future fracture risk. The objective of... Lees meer

        Gepost op 17 August 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Use of FRAX as a Determinant for Risk-Based Osteoporosis Screening May Decrease Unnecessary Testing While Improving the Odds of Identifying Treatment Candidates.

        Womens Health Issues. 2014 Aug 12; Authors: Edwards FD, Grover ML, Cook CB, Chang YH 

        PURPOSE: We have assessed the hypothetical impact of guideline-concordant osteoporosis screening on baseline behaviors... Lees meer

        Gepost op 17 August 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Duration Of Breastfeeding As A Risk Factor For Vertebral Fractures.

        Bone. 2014 Aug 10; Authors: Bolzetta F, Veronese N, De Rui M, Berton L, Carraro S, Pizzato S, Girotti G, De Ronch I, Manzato E, Coin A, Sergi G 

        PURPOSE: Among the risk factors for osteoporosis and fractures,... Lees meer

        Gepost op 17 August 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Vitamin D insufficiency over 5 years is associated with increased fracture risk-an observational cohort study of elderly women.

        Osteoporos Int. 2014 Aug 13; Authors: Buchebner D, McGuigan F, Gerdhem P, Malm J, Ridderstråle M, Akesson K

        This study of elderly Swedish women investigated the association between chronic vitamin D... Lees meer

        Gepost op 17 August 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Cost-effectiveness of vitamin D and calcium supplementation in the treatment of elderly women and men with osteoporosis.

        Eur J Public Health. 2014 Aug 5; Authors: Hiligsmann M, Ben Sedrine W, Bruyère O, Evers SM, Rabenda V, Reginster JY 

        BACKGROUND: The supplementation with vitamin D and calcium has been recommended for... Lees meer

        Gepost op 12 August 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Fracture mortality: associations with epidemiology and osteoporosis treatment.

        Nat Rev Endocrinol. 2014 Aug 5; Authors: Sattui SE, Saag KG 

        The rates of incident osteoporotic fractures seem to be stabilizing; however, fragility fractures are still associated with considerable disability,... Lees meer

        Gepost op 12 August 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Osteoporosis in patients taking selective serotonin reuptake inhibitors: a focus on fracture outcome.

        Endocrine. 2014 Aug 5; Authors: Bruyère O, Reginster JY 

        Depression is one of the most important mental health problems and a leading cause of disability. Selective serotonin reuptake inhibitors (SSRIs)... Lees meer

        Gepost op 12 August 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • A Frailty Index predicts 10-year fracture risk in adults age 25 years and older: results from the Canadian Multicentre Osteoporosis Study (CaMos).

        Osteoporos Int. 2014 Aug 8; Authors: Kennedy CC, Ioannidis G, Rockwood K, Thabane L, Adachi JD, Kirkland S, Pickard LE, Papaioannou A

        INTRODUCTION: In later life, frailty has been linked to fractures. It is likely... Lees meer

        Gepost op 12 August 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Comparison of the effect of 18-month daily teriparatide administration on patients with rheumatoid arthritis and postmenopausal osteoporosis patients.

        Osteoporos Int. 2014 Aug 1; Authors: Ebina K, Hashimoto J, Shi K, Kashii M, Hirao M, Yoshikawa H 

        INTRODUCTION: The aim of this study was to evaluate the effects of 18-month administration of daily... Lees meer

        Gepost op 05 August 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Patient perceptions of provider barriers to post-fracture secondary prevention.

        Osteoporos Int. 2014 Aug 1; Authors: Sale JE, Bogoch E, Hawker G, Gignac M, Beaton D, Jaglal S, Frankel L

        INTRODUCTION: Post-fracture secondary prevention programs have had modest effects on bone densitometry rates... Lees meer

        Gepost op 05 August 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • The role of dietary protein and vitamin D in maintaining musculoskeletal health in postmenopausal women: A consensus statement from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO).

        Maturitas. 2014 Jul 17; Authors: Rizzoli R, Stevenson JC, Bauer JM, van Loon LJ, Walrand S, Kanis JA, Cooper C, Brandi ML, Diez-Perez A, Reginster JY, for the ESCEO Task Force 

        From 50 years of age,... Lees meer

        Gepost op 05 August 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Risk factors for the second contralateral hip fracture in elderly patients: a systematic review and meta-analysis.

        CONCLUSIONS: Patients involved with female, living in institutions, osteoporosis, low vision, dizziness, dementia, respiration diseases and cardiac diseases were at risk for a second contralateral hip fracture after the... Lees meer

        Gepost op 01 August 2014

        Bron: http://www.medworm.com/inde....

      • Risk of atrial fibrillation with use of oral and intravenous bisphosphonates.

        Am J Cardiol. 2014 Jun 1;113(11):1815-21 Authors: Sharma A, Einstein AJ, Vallakati A, Arbab-Zadeh A, Walker MD, Mukherjee D, Homel P, Borer JS, Lichstein E 

        Clinical studies suggest an association between... Lees meer

        Gepost op 13 July 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Genome-wide Association Studies for Osteoporosis: A 2013 Update.

        J Bone Metab. 2014 May;21(2):99-116 Authors: Liu YJ, Zhang L, Papasian CJ, Deng HW 

        In the past few years, the bone field has witnessed great advances in genome-wide association studies (GWASs) of... Lees meer

        Gepost op 13 July 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • The risk of major and any (non-hip) fragility fracture after hip fracture in the United Kingdom: 2000-2010.

        Osteoporos Int. 2014 Jul 8; Authors: Gibson-Smith D, Klop C, Elders PJ, Welsing PM, van Schoor N, Leufkens HG, Harvey NC, van Staa TP, de Vries F 

        The risk of a subsequent major or any fracture after a hip... Lees meer

        Gepost op 13 July 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • One-year disease-related health care costs of incident vertebral fractures in osteoporotic patients.

        Osteoporos Int. 2014 Jul 8; Authors: Lange A, Zeidler J, Braun S

        INTRODUCTION: OVCF are among the most common fractures related to osteoporosis. They have been shown to be associated with excess mortality and... Lees meer

        Gepost op 13 July 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Failure in the application of fragility fracture prevention guidelines.

        CONCLUSIONS: In conjunction with NICE and NOGG recommendations, FRAX(®) was able to identify 80% of our fracture population as intermediate or high risk on the day of fracture. Correct management was evident in a third... Lees meer

        Gepost op 13 July 2014

        Bron: http://www.medworm.com/inde....

      • Distinct effect of zoledronate and clodronate on circulating levels of DKK1 and sclerostin in women with postmenopausal osteoporosis.

        Bone. 2014 Jul 5; Authors: Gatti D, Viapiana O, Idolazzi L, Fracassi E, Ionescu C, Dartizio C, Troplini S, Kunnathully V, Adami S, Rossini M 

        The coupling of bone formation to bone resorption during treatment... Lees meer

        Gepost op 13 July 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Pleiotropic Effects of Obesity on Fracture Risk: The Study of Women's Health Across the Nation.

        J Bone Miner Res. 2014 Jul 1; Authors: Ishii S, Cauley JA, Greendale GA, Nielsen C, Karvonen-Gutierrez C, Ruppert K, Karlamangla AS

        Some aspects of an obese body habitus may protect against fracture risk (higher... Lees meer

        Gepost op 08 July 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Spine Bone Texture Assessed by Trabecular Bone Score (TBS) Predicts Osteoporotic Fractures in Men: The Manitoba Bone Density Program.

        Bone. 2014 Jul 1; Authors: Leslie WD, Aubry-Rozier B, Lix LM, Morin SN, Majumdar SR, Hans D

        INTRODUCTION:: One quarter of osteoporotic fractures occur in men. TBS, a gray-level measurement derived from lumbar spine... Lees meer

        Gepost op 08 July 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Efficacy and safety of odanacatib treatment for patients with osteoporosis: a meta-analysis.

        J Bone Miner Metab. 2014 Jul 5; Authors: Feng S, Luo Z, Liu D 

        The aim of this study was to evaluate the efficacy and safety of odanacatib (ODN) for the treatment of osteoporosis, using data in studies... Lees meer

        Gepost op 08 July 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Implications of expanding indications for drug treatment to prevent fracture in older men in United States: cross sectional and longitudinal analysis of prospective cohort study.

        BMJ. 2014;349:g4120 Authors: Ensrud KE, Taylor BC, Peters KW, Gourlay ML, Donaldson MG, Leslie WD, Blackwell TL, Fink HA, Orwoll ES, Schousboe J, Osteoporotic Fractures in Men (MrOS) Study Group 

        OBJECTIVES:... Lees meer

        Gepost op 08 July 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Improving Osteoporosis Management in General Practice: A Pharmacist-Led Drug Use Evaluation Program.

        Drugs Aging. 2014 Jul 4; Authors: Tan EC, George J, Stewart K, Elliott RA

        OBJECTIVE: The aim of the study was to evaluate the impact of a drug use evaluation (DUE) program on osteoporosis management in general... Lees meer

        Gepost op 08 July 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Does long-distance training saddle young cyclists with fragile bones?

        Young cyclists training to join the Tour de France could be causing irreversible damage.The combination of cycling extreme distances and restricting caloric intake to reduce weight can decrease bone density to levels that... Lees meer

        Gepost op 04 July 2014

        Bron: http://feeds.sciencedaily.c....

      • Osteoporosis and fractures in HIV/hepatitis C virus coinfection: a systematic review and meta-analysis.

        AIDS. 2014 Jun 28; Authors: Dong HV, Cortés YI, Shiau S, Yin MT 

        OBJECTIVE:: There is growing evidence that fracture risk is increased in individuals with HIV and/or hepatitis C virus (HCV) infection.... Lees meer

        Gepost op 04 July 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Incidence of subsequent vertebral body fractures after vertebroplasty.

        J Clin Neurosci. 2014 Jun 24; Authors: Zhang YZ, Kong LD, Cao JM, Ding WY, Shen Y

        The causal relationship between vertebroplasty and new-onset vertebral fractures remains unproved. We undertook a systematic review... Lees meer

        Gepost op 30 June 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Recovery from SIADH associated Osteoporosis - a case report.

        J Clin Endocrinol Metab. 2014 Jun 27;:jc20141572 Authors: Sejling AS, Thorsteinsson AL, Pedersen-Bjergaard U, Eiken P

        Introduction: Recent studies show an association between hyponatremia and osteoporosis. We have... Lees meer

        Gepost op 30 June 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Safety of denosumab in postmenopausal women with osteoporosis or low bone mineral density: a meta-analysis.

        Int J Clin Exp Pathol. 2014;7(5):2113-22 Authors: Zhou Z, Chen C, Zhang J, Ji X, Liu L, Zhang G, Cao X, Wang P 

        Purpose: The aim of this meta-analysis was to assess the safety of denosumab in postmenopausal... Lees meer

        Gepost op 30 June 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Describing variation in the delivery of secondary fracture prevention after hip fracture: an overview of 11 hospitals within one regional area in England.

        Osteoporos Int. 2014 Jun 26; Authors: Drew S, Sheard S, Chana J, Cooper C, Javaid MK, Judge A, The REFReSH study group

        INTRODUCTION: Hip fractures are usually the result of low impact falls and underlying... Lees meer

        Gepost op 30 June 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • A report from Fukushima: an assessment of bone health in an area affected by the Fukushima nuclear plant incident.

        J Bone Miner Metab. 2013 Nov;31(6):613-7 Authors: Ishii T, Ito K, Kato S, Tsubokura M, Ochi S, Iwamoto Y, Saito Y

        Bone health was assessed for inhabitants of an area affected by the Fukushima nuclear plant... Lees meer

        Gepost op 26 June 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Steroidal contraceptives: effect on bone fractures in women.

        Cochrane Database Syst Rev. 2014 Jun 24;6:CD006033 Authors: Lopez LM, Grimes DA, Schulz KF, Curtis KM, Chen M

        BACKGROUND: Steroidal contraceptive use has been associated with changes in bone mineral density in... Lees meer

        Gepost op 26 June 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • The osteoporosis treatment gap.

        J Bone Miner Res. 2014 Jun 23; Authors: Kanis JA, Svedbom A, Harvey N, McCloskey EV

        Many guidelines for the assessment and treatment of osteoporosis recommend that intervention be considered in men and women who... Lees meer

        Gepost op 26 June 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • MicroRNA that blocks bone destruction could offer new therapeutic target for osteoporosis

        UT Southwestern cancer researchers have identified a promising molecule that blocks bone destruction and, therefore, could provide a potential therapeutic target for osteoporosis and bone metastases of cancer...

        Lees meer

        Gepost op 26 June 2014

        Bron: http://www.medworm.com/inde....

      • Mortality in British hip fracture patients, 2000 - 2010: a population-based retrospective cohort study.

        Bone. 2014 Jun 13; Authors: Klop C, Welsing PM, Cooper C, Harvey NC, Elders PJ, Bijlsma JW, Leufkens HG, de Vries F

        BACKGROUND: Data on recent trends in mortality after hip fracture are scarce. Aims were therefore... Lees meer

        Gepost op 20 June 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Serum Levels of Sclerostin and Dickkopf-1: Effects of Age, Gender and Fracture Status.

        Gerontology. 2014 Jun 12; Authors: Dovjak P, Dorfer S, Föger-Samwald U, Kudlacek S, Marculescu R, Pietschmann P

        Background: Fragility fractures, especially hip fractures, are a very common complication of... Lees meer

        Gepost op 20 June 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Long-term persistence and switching patterns among women using osteoporosis therapies: 24- and 36-month results from POSSIBLE US™

        Osteoporos Int. 2014 Jun 19; Authors: Wade SW, Satram-Hoang S, Stolshek BS

        Persistence with postmenopausal osteoporosis (PMO) medications is not well characterized beyond 12 months. Of 3,011 postmenopausal... Lees meer

        Gepost op 20 June 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Calcium Supplementation in Patients with Chronic Heart Failure: Is it Safe?

        Heart. 2014 Jun;100 Suppl 3:A31 Authors: Drozd M, Cubbon R, Gierula J, Jamil H, Crossfield S, Kearney M, Witte K

        INTRODUCTION: Recent observational studies have suggested that calcium supplementation in healthy... Lees meer

        Gepost op 15 June 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Fractures are increased and bisphosphonate use decreased in individuals with insulin-dependent diabetes: a 10 year cohort study.

        BMC Musculoskelet Disord. 2014 Jun 11;15(1):201 Authors: Fraser LA, Papaioannou A, Adachi JD, Ma J, Thabane L

        BACKGROUND: Individuals with diabetes have been found previously to be at increased risk of... Lees meer

        Gepost op 15 June 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Using a triggered endocrinology service consultation to improve the evaluation, management, and follow-up of osteoporosis in hip-fracture patients.

        Jt Comm J Qual Patient Saf. 2014 May;40(5):228-34 Authors: Hofflich HL, Oh DK, Choe CH, Clay B, Tibble C, Kulasa KM, Shah PK, Fink E, Girard PJ, Schwartz AK, Maynard GA

        BACKGROUND: Nearly 2 million... Lees meer

        Gepost op 15 June 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Time Course of Bone Mineral Density Changes With Denosumab Compared With Other Drugs in Postmenopausal Osteoporosis: A Dose-response Based Meta-analysis.

        Conclusion: This exploratory analysis shows that 3 years of treatment with denosumab resulted in bigger changes in LS and TH BMD compared with 3 years of treatment with 10 mg/day oral alendronate, 5 mg/year iv zoledronic... Lees meer

        Gepost op 15 June 2014

        Bron: http://www.medworm.com/inde....

      • Do bisphosphonates affect bone healing? A meta-analysis of randomized controlled trials.

        J Orthop Surg Res. 2014 Jun 5;9(1):45 Authors: Xue D, Li F, Chen G, Yan S, Pan Z

        BACKGROUND: Whether bisphosphonates affect indirect bone healing is still unclear. METHOD: We carried out a comprehensive search... Lees meer

        Gepost op 11 June 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Patterns of treatment among a cohort of older low-income adults starting new medications for osteoporosis.

        Osteoporos Int. 2014 Jun 5; Authors: Solomon DH, Brown EM, Chandler D, Bower A, Barron R, Mogun H, Franklin JM

        INTRODUCTION: We described patterns and predictors of OP medication use, focusing on treatment changes... Lees meer

        Gepost op 11 June 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Osteoporosis treatment disparities: a 6-year aggregate analysis from national survey data.

        Osteoporos Int. 2014 Jun 5; Authors: Cunningham TD, Di Pace BS, Ullal J

        We studied factors to determine the receipt of osteoporosis treatment in individuals with osteoporosis. Treatment was associated with age,... Lees meer

        Gepost op 11 June 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Prediction of Incident Hip Fracture with the Estimated Femoral Strength by Finite Element Analysis of DXA Scans in the Study of Osteoporotic Fractures.

        J Bone Miner Res. 2014 Jun 4; Authors: Yang L, Palermo L, Black DM, Eastell R

        A bone fractures only when loaded beyond its strength. The purpose of this study was to determine the association of femoral strength,... Lees meer

        Gepost op 11 June 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Time Course of Bone Mineral Density Changes With Denosumab Compared With Other Drugs in Postmenopausal Osteoporosis: A Dose-response Based Meta-analysis.

        J Clin Endocrinol Metab. 2014 Jun 10;:jc20133795 Authors: Mandema JW, Zheng J, Libanati C, Perez Ruixo JJ

        Objective: Our objective was to compare the time course of bone mineral density (BMD) changes at the lumbar... Lees meer

        Gepost op 11 June 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Effect of TNF-alpha inhibitor treatment on bone mineral density in patients with ankylosing spondylitis: A systematic review and meta-analysis.

        Semin Arthritis Rheum. 2014 May 9; Authors: Nigil Haroon N, Sriganthan J, Al Ghanim N, Inman RD, Cheung AM

        OBJECTIVES: Ankylosing spondylitis (AS) is a chronic inflammatory disease associated with an increased risk... Lees meer

        Gepost op 11 June 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Determinants associated with bone mineral density increase in response to daily teriparatide treatment in patients with osteoporosis.

        Bone. 2014 Jun 5; Authors: Niimi R, Kono T, Nishihara A, Hasegawa M, Matsumine A, Kono T, Sudo A

        INTRODUCTION: Several factors associated with bone mineral density (BMD) increase are reported with daily... Lees meer

        Gepost op 11 June 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • New developments in biological markers of bone metabolism in osteoporosis.

        Bone. 2014 Jun 5; Authors: Garnero P

        Over the last 15years several biological markers of bone turnover have been developed with increased specificity and sensitivity. In osteoporosis clinical studies, the IOF and... Lees meer

        Gepost op 11 June 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • The Combination of Vitamin D Deficiency and Mild to Moderate Chronic Kidney Disease Is Associated With Low Bone Mineral Density and Deteriorated Femoral Microarchitecture: Results From the KNHANES 2008-2011.

        J Clin Endocrinol Metab. 2014 May 30;:jc20133764 Authors: Lee YH, Kim JE, Roh YH, Choi HR, Rhee Y, Kang DR, Lim S

        Context: Although mild to moderate chronic kidney disease (CKD) and vitamin D deficiency are... Lees meer

        Gepost op 04 June 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Skeletal structure in postmenopausal women with osteopenia and fractures is characterized by abnormal trabecular plates and cortical thinning.

        J Bone Miner Res. 2014 May;29(5):1101-9 Authors: Stein EM, Kepley A, Walker M, Nickolas TL, Nishiyama K, Zhou B, Liu XS, McMahon DJ, Zhang C, Boutroy S, Cosman F, Nieves J, Guo XE, Shane

        The majority of fragility... Lees meer

        Gepost op 04 June 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Can change in FRAX score be used to "treat to target"? A population‐based cohort study.

        J Bone Miner Res. 2014 May;29(5):1074-80 Authors: Leslie WD, Majumdar SR, Lix LM, Morin SN, Johansson H, Odén A, McCloskey EV, Kanis JA

        It is unknown how responsive the Fracture Risk Assessment (FRAX) tool... Lees meer

        Gepost op 04 June 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • The effect of oral contraceptive different patterns of use on circulating IGF-1 and bone mineral density in healthy premenopausal women.

        Endocrine. 2014 May 27; Authors: Elkazaz AY, Salama K 

        Both insulin-like growth factor-1(IGF-1) and oral contraceptive (OC) use have been linked to premenopausal breast and colorectal cancers, osteoporosis and... Lees meer

        Gepost op 30 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Multimorbidity in women with and without osteoporosis: results from a large US retrospective cohort study 2004-2009.

        Osteoporos Int. 2014 May 24; Authors: O'Malley CD, Tran N, Zapalowski C, Daizadeh N, Olenginski TP, Cauley JA 

        INTRODUCTION: This retrospective cohort study describes the incidence of an array of... Lees meer

        Gepost op 30 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Bone metabolism and adipokines: are there perspectives for bone diseases drug discovery?

        Expert Opin Drug Discov. 2014 May 24;:1-13 Authors: Scotece M, Conde J, Abella V, López V, Pino J, Lago F, Gómez-Reino JJ, Gualillo O

        Introduction: Over the past 20 years, the idea that white adipose... Lees meer

        Gepost op 30 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Adherence and efficacy of screening for low bone mineral density among ulcerative colitis patients treated with corticosteroids.

        Am J Gastroenterol. 2014 Apr;109(4):572-8 Authors: Khan N, Abbas AM, Almukhtar RM, Cole EB, Khan AN

        OBJECTIVES: Ulcerative colitis (UC) is associated with an increased risk of metabolic bone disease and fragility... Lees meer

        Gepost op 30 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • What analytic method should clinicians use to derive spine T-scores and predict incident fractures in men? Results from the MrOS study.

        Osteoporos Int. 2014 May 22; Authors: Hansen KE, Blank RD, Palermo L, Fink HA, Orwoll ES, for the Osteoporotic Fractures in Men (MrOS) Study Research Group

        INTRODUCTION: Spine T-scores have limited ability to... Lees meer

        Gepost op 25 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • External validity of a population-based study on osteoporosis and fracture.

        Acta Orthop. 2014 May 21;:1-5 Authors: Wihlborg A, Akesson K, Gerdhem P

        Background and purpose - Little is known about the characteristics of non-participants in epidemiological studies. We evaluated external... Lees meer

        Gepost op 25 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Estimating prevalence of osteoporosis: examples from industrialized countries.

        Arch Osteoporos. 2014 Dec;9(1):182 Authors: Wade SW, Strader C, Fitzpatrick LA, Anthony MS, O'Malley CD

        PURPOSE: Standardized country-specific prevalence estimates are scarce, limiting our ability to anticipate... Lees meer

        Gepost op 25 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Evaluation of fracture risk and potential drug holidays for postmenopausal women on long-term bisphosphonate therapy.

        Int J Womens Health. 2014;6:423-8 Authors: Kostoff MD, Saseen JJ, Borgelt LM 

        STUDY OBJECTIVE: To describe characteristics of postmenopausal women on long-term bisphosphonate therapy who fall into one of four... Lees meer

        Gepost op 25 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Increased low-density lipoprotein cholesterol level is associated with non-vertebral fractures in postmenopausal women.

        Endocrine. 2014 May 23; Authors: Yamauchi M, Yamaguchi T, Nawata K, Tanaka KI, Takaoka S, Sugimoto T

        Although a high serum low-density lipoprotein cholesterol (LDL-C) level is an established risk factor for... Lees meer

        Gepost op 25 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • NCCN Bone Health Task Force: Key Recommendations.

        J Natl Compr Canc Netw. 2014 May;12(5 Suppl):813-6 Authors: Farooki A 

        For patients with advanced cancers involving bone, the standard of care for maintaining bone health is the use of antiresorptive therapies... Lees meer

        Gepost op 25 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Vitamin D supplementation and lipid profile: What does the best available evidence show?

        Atherosclerosis. 2014 Apr 30;235(1):130-139 Authors: Challoumas D

        Vitamin D supplements have increasingly been used for the treatment and prevention of osteoporosis. Historically, effects of the vitamin on the... Lees meer

        Gepost op 21 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Vitamin k2 therapy for postmenopausal osteoporosis.

        Nutrients. 2014;6(5):1971-80 Authors: Iwamoto J

        Vitamin K may play an important role in the prevention of fractures in postmenopausal women with osteoporosis. Menatetrenone is the brand name of a synthetic vitamin... Lees meer

        Gepost op 21 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Subgroup Variations in Bone Mineral Density Response to Zoledronic Acid Following Hip Fracture.

        J Bone Miner Res. 2014 May 16; Authors: Magaziner JS, Orwig DL, Lyles KW, Nordsletten L, Boonen S, Adachi JD, Recknor C, Colón-Emeric CS, Mesenbrink P, Bucci-Rechtweg C, Su G, Johnson R, Pieper CF 

        ... Lees meer

        Gepost op 21 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Secondary osteoporosis and metabolic bone disease in patients 50 years and older with osteoporosis or with a recent clinical fracture: a clinical perspective.

        Curr Opin Rheumatol. 2014 May 17; Authors: Bours SP, van den Bergh JP, van Geel TA, Geusens PP

        PURPOSE OF REVIEW: The purpose of this review is to provide guidance to clinicians about which laboratory tests should... Lees meer

        Gepost op 21 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Medication Use Before and After Hip Fracture: A Population-Based Cohort and Case-Control Study.

        Drugs Aging. 2014 May 14; Authors: Rossini M, Viapiana O, Adami S, Idolazzi L, Buda S, Veronesi C, Degli Esposti L, Gatti D 

        BACKGROUND: Osteoporosis, together with age, is the main risk factor for hip... Lees meer

        Gepost op 18 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Estimated Lean Mass and Fat Mass Differentially Affect Femoral Bone Density and Strength Index But Are Not FRAX Independent Risk Factors for Fracture.

        J Bone Miner Res. 2014 May 13; Authors: Leslie WD, Orwoll ES, Nielson CM, Morin SN, Majumdar SR, Johansson H, Odén A, McCloskey EV, Kanis JA 

        Although increasing body weight has been regarded as... Lees meer

        Gepost op 18 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Effect of Odanacatib on BMD and Fractures: Estimates from Bayesian Univariate and Bivariate Meta-analyses.

        J Clin Endocrinol Metab. 2014 May 13;:jc20141162 Authors: Gajic-Veljanoski O, Tomlinson G, Srighanthan J, Adachi JD, Josse R, Brown JP, Cheung AM

        Context: Odanacatib (ODN), a selective cathepsin-K inhibitor, was... Lees meer

        Gepost op 18 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Increase in bone density in patients with spondyloarthritis during anti-tumor necrosis factor therapy: 6-year followup study.

        J Rheumatol. 2013 Oct;40(10):1712-8 Authors: Durnez A, Paternotte S, Fechtenbaum J, Landewé RB, Dougados M, Roux C, Briot K

        OBJECTIVE: To assess the effects on bone mineral... Lees meer

        Gepost op 18 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Are young women and men with rheumatoid arthritis at risk for fragility fractures? A population-based study.

        J Rheumatol. 2013 Oct;40(10):1669-76 Authors: Amin S, Gabriel SE, Achenbach SJ, Atkinson EJ, Melton LJ

        OBJECTIVE: Older women and men with rheumatoid arthritis (RA) are at increased risk for fractures, but limited... Lees meer

        Gepost op 18 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Effects of walking on the preservation of bone mineral density in perimenopausal and postmenopausal women: a systematic review and meta-analysis.

        Menopause. 2013 Nov;20(11):1216-26 Authors: Ma D, Wu L, He Z 

        OBJECTIVE: This study aims to critically evaluate the effects of a walking intervention on bone mineral density (BMD) in perimenopausal and... Lees meer

        Gepost op 14 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Calcium supplements not associated with increased risk of cardiovascular disease in women

        Calcium supplements are widely taken by women for bone health. Previous studies have suggested that calcium supplements may increase risk of cardiovascular disease, but the data has been inconsistent. A new study did not... Lees meer

        Gepost op 14 May 2014

        Bron: http://feeds.sciencedaily.c....

      • The Association between Aortic Calcification and Fracture Risk in Postmenopausal Women in China: The Prospective Chongqing Osteoporosis Study.

        PLoS One. 2014;9(5):e93882 Authors: Zhou R, Zhou H, Cui M, Chen L, Xu J 

        PURPOSE: Fractures are associated with cardiovascular diseases in the elderly. The purpose of the present study was to investigate the... Lees meer

        Gepost op 14 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Insulinogenic sucrose+amino acid mixture ingestion immediately after resistance exercise has an anabolic effect on bone compared with non-insulinogenic fructose+amino acid mixture in growing rats.

        Bone. 2014 May 8; Authors: Notomi T, Karasaki I, Okazaki Y, Okimoto N, Kato Y, Ohura K, Noda M, Nakamura T, Suzuki M

        Maximizing peak bone mass is an important factor in osteoporosis prevention. Resistance exercise... Lees meer

        Gepost op 14 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Osteoporosis and Fractures After Solid Organ Transplantation: A Nationwide Population-Based Cohort Study.

        Mayo Clin Proc. 2014 May 5; Authors: Yu TM, Lin CL, Chang SN, Sung FC, Huang ST, Kao CH 

        OBJECTIVE: To investigate the incidence of bone disorders after solid organ transplantation (SOT). PARTICIPANTS AND... Lees meer

        Gepost op 11 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Whole body bone tissue and cardiovascular risk in rheumatoid arthritis.

        J Osteoporos. 2014;2014:465987 Authors: Popescu C, Bojincă V, Opriş D, Ionescu R

        Introduction. Atherosclerosis and osteoporosis share an age-independent bidirectional correlation. Rheumatoid arthritis (RA)... Lees meer

        Gepost op 11 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Teriparatide Therapy for Denosumab-Induced Osteonecrosis of the Jaw in a Male Osteoporotic Patient.

        Calcif Tissue Int. 2014 May 8; Authors: Neuprez A, Rompen E, Crielaard JM, Reginster JY

        We report the first case of teriparatide adjuvant role in the management of a denosumab-induced osteonecrosis of the jaw in a... Lees meer

        Gepost op 11 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Critical impact of patient knowledge and bone density testing on starting osteoporosis treatment after fragility fracture: secondary analyses from two controlled trials.

        Osteoporos Int. 2014 May 7; Authors: Majumdar SR, McAlister FA, Johnson JA, Weir DL, Bellerose D, Hanley DA, Russell AS, Rowe BH 

        INTRODUCTION: In the year following fragility fracture, fewer than one quarter... Lees meer

        Gepost op 11 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • The anti-diabetic drug metformin does not affect bone mass in vivo or fracture healing.

        Osteoporos Int. 2013 Oct;24(10):2659-70 Authors: Jeyabalan J, Viollet B, Smitham P, Ellis SA, Zaman G, Bardin C, Goodship A, Roux JP, Pierre M, Chenu C 

        INTRODUCTION: In view of the increased incidence of... Lees meer

        Gepost op 11 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Bone Mineral Density Changes Following Discontinuation of Ronacaleret Treatment: Off-treatment Extension of a Randomized, Dose-finding Phase II Trial.

        Bone. 2014 Apr 30; Authors: Fitzpatrick LA, Wooddell M, Dabrowski CE, Cicconetti G, Gordon DN 

        CONTEXT: Parathyroidectomy in patients with hyperparathyroidism can produce subsequent increases in bone mineral... Lees meer

        Gepost op 07 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Evaluation of the FRAX Model for Hip Fracture Predictions in the Population-based Kuopio Osteoporosis Risk Factor and Prevention Study (OSTPRE).

        Calcif Tissue Int. 2014 May 4; Authors: Sund R, Honkanen R, Johansson H, Odén A, McCloskey E, Kanis J, Kröger H

        Calibration of the Finnish FRAX model was evaluated using a locally derived... Lees meer

        Gepost op 07 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Effect of supplemental vitamin D and calcium on serum sclerostin levels.

        Eur J Endocrinol. 2014 Apr;170(4):645-50 Authors: Dawson-Hughes B, Harris SS, Ceglia L, Palermo NJ 

        OBJECTIVE: Serum sclerostin levels have been reported to be inversely associated with serum 25OHD levels, but... Lees meer

        Gepost op 04 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Vitamin D supplementation increases calcium absorption without a threshold effect.

        Am J Clin Nutr. 2014 Mar;99(3):624-31 Authors: Aloia JF, Dhaliwal R, Shieh A, Mikhail M, Fazzari M, Ragolia L, Abrams SA

        BACKGROUND: The maximal calcium absorption in response to vitamin D has been proposed as a... Lees meer

        Gepost op 04 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Association Between Use of Antiepileptic Drugs and Fracture Risk: A Systematic Review and Meta-analysis.

        Bone. 2014 Apr 25; Authors: Shen C, Chen F, Zhang Y, Guo Y, Ding M

        BACKGROUND: It has been shown that antiepileptic drugs (AEDs) may have a detrimental effect on bone health and translate into an increased risk of... Lees meer

        Gepost op 04 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Prevalence of osteoporosis in men aged 65-75 in a primary care setting. A practice audit after application of the Canadian 2010 guidelines for osteoporosis screening.

        Clin Rheumatol. 2014 Apr 30; Authors: Ferrari R

        Current Canadian osteoporosis guidelines recommend routine bone density screening of men at age 65. The purpose of this study is to determine the prevalence of... Lees meer

        Gepost op 04 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Practical guide to bone health in the spectrum of advanced prostate cancer.

        Can J Urol. 2014 Apr;21(2 Supp 1):84-92 Authors: Butoescu V, Tombal B

        INTRODUCTION: In the advanced stage of prostate cancer, bone is consistently the first and, later on, the dominant extra-nodal metastatic site.... Lees meer

        Gepost op 04 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • The Recent Prevalence of Osteoporosis and Low Bone Mass in the United States Based on Bone Mineral Density at the Femoral Neck or Lumbar Spine.

         J Bone Miner Res. 2014 Apr 26; Authors: Wright NC, Looker AC, Saag KG, Curtis JR, Delzell ES, Randall S, Dawson-Hughes B

        The goal of our study was to estimate the prevalence of osteoporosis and low bone mass... Lees meer

        Gepost op 04 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • AXT914 a novel, orally-active parathyroid hormone-releasing drug in two early studies of healthy volunteers and postmenopausal women.

        Bone. 2014 Apr 24; Authors: John MR, Harfst E, Loeffler J, Belleli R, Mason J, Bruin GJ, Seuwen K, Klickstein LB, Mindeholm L, Widler L, Kneissel M

        Antagonism of the calcium-sensing receptor in the parathyroid... Lees meer

        Gepost op 04 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Handgrip Strength but not Appendicular Lean Mass is an Independent Predictor of Functional Outcome in Hip-Fracture Women: A Short-Term Prospective Study.

        Arch Phys Med Rehabil. 2014 Apr 21; Authors: Di Monaco M, Castiglioni C, De Toma E, Gardin L, Giordano S, Di Monaco R, Tappero R 

        OBJECTIVE: To investigate the contribution of muscle mass and handgrip strength... Lees meer

        Gepost op 04 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Prevalence of vitamin D inadequacy in European women aged over 80 years.

        Arch Gerontol Geriatr. 2014 Apr 5; Authors: Bruyère O, Slomian J, Beaudart C, Buckinx F, Cavalier E, Gillain S, Petermans J, Reginster JY

        Inadequate vitamin D status is associated with secondary... Lees meer

        Gepost op 04 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Bone health in cancer patients: ESMO Clinical Practice Guidelines.

        Ann Oncol. 2014 Apr 29; Authors: Coleman R, Body JJ, Aapro M, Hadji P, Herrstedt J, on behalf of the ESMO Guidelines Working Group 

        There are three distinct areas of cancer management that make bone health in... Lees meer

        Gepost op 04 May 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Emerging multifunctional roles of Claudin tight junction proteins in bone.

        Endocrinology. 2014 Apr 23;:en20141173 Authors: Alshbool FZ, Mohan S

        The imbalance between bone formation and resorption during bone remodeling has been documented to be a major factor in the pathogenesis of... Lees meer

        Gepost op 25 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Calcium and Vitamin D in Sarcoidosis: Is Supplementation Safe?

        J Bone Miner Res. 2014 Apr 18; Authors: Kamphuis LS, Bonte-Mineur F, van Laar JA, van Hagen PM, van Daele PL

        Granulomas in sarcoidosis express high levels of 1α-hydroxylase, an enzyme that catalyzes the... Lees meer

        Gepost op 23 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • 7 Tesla MRI of bone microarchitecture discriminates between women without and with fragility fractures who do not differ by bone mineral density.

        J Bone Miner Metab. 2014 Apr 22; Authors: Chang G, Honig S, Liu Y, Chen C, Chu KK, Rajapakse CS, Egol K, Xia D, Saha PK, Regatte RR  

        Osteoporosis is a disease of poor bone quality. Bone mineral density (BMD)... Lees meer

        Gepost op 23 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Insights from the Global Longitudinal Study of Osteoporosis in Women (GLOW).

        Nat Rev Endocrinol. 2014 Apr 22; Authors: Watts NB

        GLOW is an observational, longitudinal, practice-based cohort study of osteoporosis in 60,393 women aged ≥55 years in 10 countries on three continents. In this... Lees meer

        Gepost op 23 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Prenatal Calcium and Vitamin D Intake, and Bone Mass in Later Life.

        Curr Osteoporos Rep. 2014 Apr 17; Authors: Curtis EM, Moon RJ, Dennison EM, Harvey NC

        The aging population will result in an increasing burden of osteoporotic fractures, necessitating the identification of novel... Lees meer

        Gepost op 21 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Rates of Non-vertebral Osteoporotic Fractures in Rheumatoid Arthritis and Postfracture Osteoporosis Care in a Period of Evolving Clinical Practice Guidelines.

        Calcif Tissue Int. 2014 Apr 16; Authors: Roussy JP, Bessette L, Bernatsky S, Rahme E, Lachaine J  

        In 2002, guidelines for the management of osteoporosis were published by Osteoporosis Canada and widely... Lees meer

        Gepost op 21 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Associations between objectively-measured sedentary behaviour and physical activity with bone mineral density in adults and older adults, the NHANES study.

        Bone. 2014 Apr 12; Authors: Chastin SF, Mandrichenko O, Helbostadt JL, Skelton DA  

        BACKGROUND: Lack of physical activity (PA) is an important modifiable risk factor for bone mineral density (BMD). Time spent... Lees meer

        Gepost op 21 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Obstructive Sleep Apnea and Risk of Osteoporosis: A Population-Based Cohort Study in Taiwan.

        J Clin Endocrinol Metab. 2014 Apr 15;:jc20141718 Authors: Chen YL, Weng SF, Shen YC, Chou CW, Yang CY, Wang JJ, Tien KJ 

        Background: Obstructive sleep apnea (OSA) is associated with metabolic, endocrine, and... Lees meer

        Gepost op 21 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Proton pump inhibitor use and fracture risk - effect modification by histamine H1 receptor blockade. Observational case-control study using National Prescription Data.

        Bone. 2013 Nov;57(1):269-71 Authors: Abrahamsen B, Vestergaard P

        It remains unknown why proton pump inhibitor (PPI) use may be associated with risk of osteoporotic fractures; evidence of direct effects on calcium... Lees meer

        Gepost op 21 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Added value of trabecular bone score to bone mineral density for prediction of osteoporotic fractures in postmenopausal women: the OPUS study.

        Bone. 2013 Nov;57(1):232-6 Authors: Briot K, Paternotte S, Kolta S, Eastell R, Reid DM, Felsenberg D, Glüer CC, Roux C 

        The objective of this study was to consider whether trabecular bone score (TBS)... Lees meer

        Gepost op 21 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Effectiveness of risedronate and alendronate on nonvertebral fractures: an observational study through 2 years of therapy.

        Osteoporos Int. 2013 Aug;24(8):2345-52 Authors: Lindsay R, Watts NB, Lange JL, Delmas PD, Silverman SL 

        INTRODUCTION: Post hoc analyses of the placebo-controlled trials suggested earlier effects for... Lees meer

        Gepost op 21 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • The bone-fat interface: basic and clinical implications of marrow adiposity.

        Lancet Diabetes Endocrinol. 2014 Feb 19; Authors: Devlin MJ, Rosen CJ 

        Obesity and osteoporosis are two of the most common chronic disorders of the 21st century. Both are accompanied by significant morbidity.... Lees meer

        Gepost op 16 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men.

        Cochrane Database Syst Rev. 2014 Apr 14;4:CD000227 Authors: Avenell A, Mak JC, O'Connell D

        BACKGROUND: Vitamin D and related compounds have been used to prevent osteoporotic fractures in older people. This is... Lees meer

        Gepost op 16 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Osteoporosis drugs appear to impede cell membrane repair

        A class of drugs widely used to treat osteoporosis appears to impede a cell's ability to repair a protective outer membrane that helps determine what enters and exits, researchers report. The inability to quickly repair... Lees meer

        Gepost op 16 April 2014

        Bron: http://feeds.sciencedaily.c....

      • Capture the Fracture

        In April 2013, IOF officially launched the Capture the Fracture programme, a multi-stakeholder campaign to prevent secondary fractures due to osteoporosis through the implementation of Fracture Liaison Services (FLS)... Lees meer

        Gepost op 16 April 2014

        Bron: http://www.iofbonehealth.or....

      • Examining the impact of reimbursement on referral to bone density testing for older adults: 8 years of data from the Barwon Statistical Division, Australia.

        Arch Osteoporos. 2013;8(1-2):152 Authors: Brennan SL, Kotowicz MA, Sarah B, Leslie WD, Ebeling PR, Metge CJ, Dobbins AG, Pasco JA 

        INTRODUCTION: On April 1, 2007 Medicare Australia revised reimbursement... Lees meer

        Gepost op 13 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Hyperkyphosis, Kyphosis Progression, and Risk of Non-Spine Fractures in Older Community Dwelling Women: The Study of Osteoporotic Fractures (SOF).

        J Bone Miner Res. 2014 Apr 9; Authors: Kado DM, Miller-Martinez D, Lui LY, Cawthon P, Katzman WB, Hillier TA, Fink HA, Ensrud KE

        While accentuated kyphosis is associated with osteoporosis, it is unknown whether it... Lees meer

        Gepost op 13 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Inflammatory Markers and Risk of Hip Fracture in Older White Women: The Study of Osteoporotic Fractures.

        J Bone Miner Res. 2014 Apr 9; Authors: Barbour KE, Lui LY, Ensrud KE, Hillier TA, Leblanc ES, Ing SW, Hochberg MC, Cauley JA, for the Study of Osteoporotic Fractures (SOF) Research Group 

        Hip fractures are the... Lees meer

        Gepost op 13 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Low Serum Thyrotropin Level and Duration of Suppression as a Predictor of Major Osteoporotic Fractures - The OPENTHYRO Register Cohort.

        J Bone Miner Res. 2014 Apr 9; Authors: Abrahamsen B, Jørgensen HL, Laulund AS, Nybo M, Brix TH, Hegedüs L

        BACKGROUND: The relationship between thyrotoxicosis and osteoporotic fractures remains... Lees meer

        Gepost op 13 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Prevalence and determinants of osteoporosis in patients with type 1 and type 2 diabetes mellitus.

        BMC Endocr Disord. 2014 Apr 11;14(1):33 Authors: Leidig-Bruckner G, Grobholz S, Bruckner T, Scheidt-Nave C, Nawroth P, Schneider JG

        BACKGROUND: Increased risk of osteoporosis and its clinical significance in... Lees meer

        Gepost op 13 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • U.S. adults meeting 2010 American College of Rheumatology criteria for treatment and prevention of glucocorticoid-induced osteoporosis.

        Arthritis Care Res (Hoboken). 2014 Apr 9; Authors: Overman RA, Toliver JC, Yeh JY, Gourlay ML, Deal CL

        Background/Purpose: The American College of Rheumatology (ACR) updated its guidelines on the prevention and... Lees meer

        Gepost op 13 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • A service development study of the assessment and management of fracture risk in Parkinson's disease.

        J Neurol. 2014 Apr 10; Authors: Shribman S, Torsney KM, Noyce AJ, Giovannoni G, Fearnley J, Dobson R

        Parkinson's disease (PD) is associated with an increased risk of fragility fracture. FRAX and Qfracture are... Lees meer

        Gepost op 13 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Pharmacists Can Use FRAX to Identify Osteoporosis Risk

        The pharmacist can help prevent osteoporosis from occurring and, in those who already have the condition, help minimale risk for fracture, according to a presentation at the American Pharmacists Association (APhA) 2014... Lees meer

        Gepost op 13 April 2014

        Bron: http://news.google.com/news....

      • Trabecular Microfractures in the Femoral Head with Osteoporosis: Analysis of Microcallus Formations by Synchrotron Radiation Micro CT.

        Bone. 2014 Apr 2; Authors: Okazaki N, Chiba K, Taguchi K, Nango N, Kubota S, Ito M, Osaki M

        Trabecular bone microfracture pathogenesis and associated healing processes are not well understood. We analyzed the... Lees meer

        Gepost op 09 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Incremental Predictive Value of Sarcopenia for Incident Fracture in an Elderly Chinese Cohort: Results From the Osteoporotic Fractures in Men (MrOs) Study.

         J Am Med Dir Assoc. 2014 Apr 2; Authors: Yu R, Leung J, Woo J 

        OBJECTIVES: We examined whether sarcopenia is predictive of incident fractures among older men, whether the inclusion of sarcopenia in... Lees meer

        Gepost op 09 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Usefulness of bone density measurement in fallers.

        Joint Bone Spine. 2014 Apr 2; Authors: Blain H, Rolland Y, Beauchet O, Annweiler C, Benhamou CL, Benetos A, Berrut G, Audran M, Bendavid S, Bousson V, Briot K, Brazier M, Breuil V, Chapuis L, Chapurlat R, Cohen-Solal M,... Lees meer

        Gepost op 09 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • There is still a care gap in osteoporosis management for patients with rheumatoid arthritis.

        Joint Bone Spine. 2014 Apr 2; Authors: Watt J, Thompson A, Le Riche N, Pope J 

        OBJECTIVES: To assess compliance rates with the current Canadian osteoporosis guidelines and whether the Fracture Risk Assessment... Lees meer

        Gepost op 09 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Bone marrow fat.

        Joint Bone Spine. 2014 Apr 1; Authors: Hardouin P, Pansini V, Cortet B

        Bone marrow fat (BMF) results from an accumulation of fat cells within the bone marrow. Fat is not a simple filling tissue but is now... Lees meer

        Gepost op 09 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • International and ethnic variability of falls in older men.

        Scand J Public Health. 2014 Mar;42(2):194-200 Authors: Karlsson MK, Ribom EL, Nilsson JÅ, Karlsson C, Cöster M, Vonschewelov T, Mallmin H, Ljunggren Ö, Ohlsson C, Mellström D, Lorentzon M, Leung PC, Lau... Lees meer

        Gepost op 09 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Three New Reports of the IOF

        Providing evidence-based solutions Three groundbreaking new reports published by IOF in 2013 reveal the burden of osteoporosis in Europe and the Asia-Pacific. The reports are being used by national osteoporosis societies as... Lees meer

        Gepost op 09 April 2014

        Bron: http://www.iofbonehealth.or....

      • Interaction between Muscle and Bone.

         J Bone Metab. 2014 Feb;21(1):29-40 Authors: Kaji H

        The clinical significance of sarcopenia and osteoporosis has increased with the increase in the population of older people. Sarcopenia is defined by... Lees meer

        Gepost op 09 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Long-term risk of medical conditions associated with breast cancer treatment.

        Breast Cancer Res Treat. 2014 Apr 3; Authors: Hill DA, Horick NK, Isaacs C, Domchek SM, Tomlinson GE, Lowery JT, Kinney AY, Berg JS, Edwards KL, Moorman PG, Plon SE, Strong LC, Ziogas A, Griffin CA, Kasten CH, Finkelstein... Lees meer

        Gepost op 06 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Declining rates of osteoporosis management following fragility fractures in the u.s., 2000 through 2009.

         J Bone Joint Surg Am. 2014 Apr 2;96(7):e52 Authors: Balasubramanian A, Tosi LL, Lane JM, Dirschl DR, Ho PR, O'Malley CD  

        Clinical practice recommendations state that patients with fragility... Lees meer

        Gepost op 06 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • The global burden attributable to low bone mineral density.

        Ann Rheum Dis. 2014 Apr 1; Authors: Sànchez-Riera L, Carnahan E, Vos T, Veerman L, Norman R, Lim SS, Hoy D, Smith E, Wilson N, Nolla JM, Chen JS, Macara M, Kamalaraj N, Li Y, Kok C, Santos-Hernández C, March... Lees meer

        Gepost op 06 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Effects of up to 5 Years of Denosumab Treatment on Bone Histology and Histomorphometry: The FREEDOM Study Extension.

        J Bone Miner Res. 2014 Apr 1; Authors: Brown JP, Reid IR, Wagman RB, Kendler D, Miller PD, Jensen JE, Bolognese MA, Daizadeh N, Valter I, Zerbini CA, Dempster DW

        Denosumab reduced bone resorption, increased BMD,... Lees meer

        Gepost op 06 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Economic evaluation of an osteoporosis screening campaign using FRAX

        In new research presented at the World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases today, investigators showed that an osteoporosis screening strategy using FRAX as a pre-screening tool is... Lees meer

        Gepost op 06 April 2014

        Bron: http://news.google.com/news....

      • New FRAX app launched by the International Osteoporosis Foundation

        Osteoporosis management guidelines around the world now recommend that fracture risk assessment be part of any clinical evaluation for osteoporosis. As a result, rather than relying on bone mineral density values alone,... Lees meer

        Gepost op 06 April 2014

        Bron: http://news.google.com/news....

      • EMAS position statement: The management of postmenopausal women with vertebral osteoporotic fracture.

        Maturitas. 2014 Mar 7; Authors: Triantafyllopoulos IK, Lambropoulou-Adamidou K, Nacopoulos CC, Papaioannou NA, Ceausu I, Depypere H, Erel CT, Pérez-López FR, Schenck-Gustafsson K, van der Schouw YT, Simoncini... Lees meer

        Gepost op 02 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • TBS result is not affected by lumbar spine osteoarthritis.

        Osteoporos Int. 2014 Apr 1; Authors: Kolta S, Briot K, Fechtenbaum J, Paternotte S, Armbrecht G, Felsenberg D, Glüer CC, Eastell R, Roux C .

        INTRODUCTION: Lumbar... Lees meer

        Gepost op 02 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Patterns and predictors of osteoporosis medication discontinuation and switching among Medicare beneficiaries.

        BMC Musculoskelet Disord. 2014 Apr 1;15(1):112 Authors: Yun H, Curtis JR, Guo L, Kilgore M, Muntner P, Saag K, Matthews R, Morrisey M, Wright NC, Becker DJ, Delzell E 

        BACKGROUND: Low adherence to... Lees meer

        Gepost op 02 April 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Meta-analysis of risk factors for the second hip fracture (SHF) in elderly patients.

        Arch Gerontol Geriatr. 2014 Mar 20; Authors: Zhu Y, Chen W, Sun T, Zhang Q, Cheng J, Zhang Y

        This study aims to quantitatively summarize the risk factors for the incidence of SHF. A meta-analysis was performed with... Lees meer

        Gepost op 30 March 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • NCCN Task Force Report: Bone Health In Cancer Care.

        J Natl Compr Canc Netw. 2013 Aug;11 Suppl 3:S1-50; quiz S51 Authors: Gralow JR, Biermann JS, Farooki A, Fornier MN, Gagel RF, Kumar R, Litsas G, McKay R, Podoloff DA, Srinivas S, Van Poznak CH

        Bone health and... Lees meer

        Gepost op 30 March 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Alendronate-induced atypical bone fracture: evidence that the drug inhibits osteogenesis.

        J Clin Pharm Ther. 2014 Mar 24; Authors: Patntirapong S, Singhatanadgit W, Arphavasin S

        OBJECTIVE: Alendronate (ALN) is used for the treatment of post-menopausal osteoporosis. By reducing bone turnover, it... Lees meer

        Gepost op 30 March 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Predictors of Excess Mortality Following Fracture: A Population-Based Cohort Study.

        J Bone Miner Res. 2014 Feb 12; Authors: Melton LJ, Atkinson EJ, St Sauver JL, Achenbach SJ, Therneau TM, Rocca WA, Amin S

        To determine the extent to which excess mortality following fractures due to particular... Lees meer

        Gepost op 30 March 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Impacts of Body Mass Index, Physical Activity, and Smoking on Femoral Bone Loss. The Tromsø Study.

        J Bone Miner Res. 2014 Mar 28; Authors: Emaus N, Wilsgaard T, Ahmed LA

        Bone mineral density (BMD) is a reflection of bone strength and lifestyles that preserve bone mass may reduce fracture risk in old age. This... Lees meer

        Gepost op 30 March 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Age discrimination in osteoporosis screening—Data from the Aalborg University Hospital Record for Osteoporosis Risk Assessment (AURORA)

        We report data from the 8,131 consecutive evaluations in 7914 individuals at the Osteoporosis Clinic from January 1st 2010 through December 31st 2012.Results: Risk factor data were available in >96% and DXA in 98%.... Lees meer

        Gepost op 30 March 2014

        Bron: http://www.medworm.com/inde....

      • Melk drinken tijdens tienerjaren helpt niet om osteoporose te voorkomen

        Vaak wordt aangeraden om tijdens de kinder- en tienerjaren veel melk te drinken, om op die manier voldoende botmassa op te bouwen en op latere leeftijd botontkalking (osteoporose) te voorkomen. Een nieuw Amerikaans onderzoek... Lees meer

        Gepost op 30 March 2014

        Bron: http://news.google.com/news....

      • OPG and sRANKL serum levels and incident hip fracture in postmenopausal Caucasian women in the Women's Health Initiative Observational Study.

        Bone. 2013 Oct;56(2):474-81 Authors: LaCroix AZ, Jackson RD, Aragaki A, Kooperberg C, Cauley JA, Chen Z, Leboff MS, Duggan D, Wactawski-Wende J

        PURPOSE: The osteoprotogerin/receptor activator of NF-kappa... Lees meer

        Gepost op 25 March 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Use of strontium ranelate and risk of acute coronary syndrome: cohort study.

        Ann Rheum Dis. 2014 Mar 20; Authors: Svanström H, Pasternak B, Hviid A

        BACKGROUND: A recent pooled analysis of randomised trials found an increased risk of myocardial infarction with use of the... Lees meer

        Gepost op 25 March 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Early Changes in Bone Density, Micro-Architecture, Bone Resorption and Inflammation Predict the Clinical Outcome 12 Weeks After Conservatively Treated Distal Radius Fractures: An Exploratory Study.

        Fracture healing is an active process with early changes in bone and inflammation. We performed an exploratory study evaluating the association between early changes in densitometric, structural, biomechanical and... Lees meer

        Gepost op 22 March 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Effects of Odanacatib on the Radius and Tibia of Postmenopausal Women: Improvements in Bone Geometry, Microarchitecture and Estimated Bone Strength.

        The cathepsin K inhibitor odanacatib, currently in phase 3 development for postmenopausal osteoporosis, has a novel mechanism of action that reduces bone resorption while maintaining bone formation. In phase 2 studies,... Lees meer

        Gepost op 22 March 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Biochemical Markers of Bone Turnover in Chronic Obstructive Pulmonary Disease (COPD).

        Osteoporosis has a higher prevalence in COPD patients and its etiology is very complex, it has been linked with reduced physical activity, low body mass index (BMD), a worse degree of airflow limitation and... Lees meer

        Gepost op 19 March 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • The effects of bazedoxifene in the ovariectomized aged cynomolgus monkey.

        Bazedoxifene (BZA) is a novel selective estrogen receptor modulator in clinical development for the prevention and treatment of postmenopausal osteoporosis. This preclinical study evaluated the efficacy and safety of BZA in... Lees meer

        Gepost op 19 March 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Evaluation of the anti-osteoporotic effects of metformin and sitagliptin in postmenopausal diabetic women.

        Osteoporosis is the most important metabolic bone disease in patients with diabetes mellitus. Several studies have documented that metformin is osteogenic in vitro. In contrast, others showed no effect of metformin on the... Lees meer

        Gepost op 19 March 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Interrelationship among muscle, fat, and bone: Connecting the dots on cellular, hormonal, and whole body levels.

        While sarcopenia and sarcopenic obesity have been recognized in the last decade, a combined concept to include decreased muscle mass and strength, as well as decreased bone mass with coexistence of adiposity is discussed... Lees meer

        Gepost op 19 March 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • The association between plasma homocysteine levels and bone quality and bone mineral density parameters in older persons.

        INTRODUCTION: High plasma homocysteine levels have been associated with incident osteoporotic fractures, but the mechanisms underlying this association are still unknown. It has been hypothesized that homocysteine might... Lees meer

        Gepost op 19 March 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Clinical treatment outcomes for 40 patients with bisphosphonates-related osteonecrosis of the jaws.

        BACKGROUND/PURPOSE: Bisphosphonates (BPs) are used to treat osteoporosis and bone metastases from malignancy. They may result in BPs-related osteonecrosis of the jaws (BRONJ) in a subset of patients receiving BPs. This study... Lees meer

        Gepost op 19 March 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Serum periostin is associated with fracture risk in postmenopausal women: a 7 years prospective analysis of the OFELY study.

        Purpose: Periostin (POSTN) is a secreted gamma-carboxyglutamic acid-containing protein (Gla protein) expressed mainly in the periosteum in adult individuals. POSNT deficient mice develop periodontis and osteoporosis with... Lees meer

        Gepost op 19 March 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • National Bone Health Alliance Clinical Diagnosis of Osteoporosis Working ...

        The National Bone Health Alliance (NBHA) Clinical Diagnosis of Osteoporosis Working Group recommends expanding the criteria for making a diagnosis of osteoporosis to include all post-menopausal women and all men age 50 en... Lees meer

        Gepost op 19 March 2014

        Bron: http://news.google.com/news....

      • Bone mass behavior after 1 year of different treatment strategies in prostate cancer patients subjected to androgen deprivation therapy.

        The aim of this study was to evaluate bone mass changes after 1 year of four different types of pharmacological intervention. Ninety-seven prostate cancer patients treated with androgen deprivation therapy, and severe... Lees meer

        Gepost op 16 March 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Choice of Lumbar Spine Bone Density Reference Database for Fracture Prediction in Men and Women: A Population-Based Analysis.

        The diagnosis of osteoporosis in men is controversial, although most studies demonstrate similar fracture rates for men and women with the same level of hip bone mineral density (BMD). Whether this applies to the lumbar... Lees meer

        Gepost op 16 March 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Fracture incidence after 3 years of aromatase inhibitor therapy.

        BACKGROUND: The purpose of this study was to describe the fracture incidence and bone mineral density (BMD) evolution in a large cohort of post-menopausal women with breast cancer after 3 years of aromatase inhibitor (AI)... Lees meer

        Gepost op 16 March 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Mortality following the first hip fracture in Norwegian women and men 1999-2008. A NOREPOS study.

        Hip fractures are associated with increased mortality and their incidence in Norway is one of the highest worldwide. The aim of this nationwide study was to examine short and long term mortality after hip fractures, burden... Lees meer

        Gepost op 16 March 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Anti-osteoporotic drugs and vascular calcification: the bidirectional calcium traffic.

        During the last years, numerous epidemiological studies have demonstrated a direct relationship between vascular calcification and low bone mineral density. This observation is in line with experimental data demonstrating... Lees meer

        Gepost op 16 March 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Plasma level of homocysteine associated with severe vertebral fracture in postmenopausal women.

        The aim of this cross-sectional cohort study was to clarify risk factors for severe vertebral fractures in postmenopausal Japanese women. Subjects were ambulatory volunteers age over 50 years who were recruited from a... Lees meer

        Gepost op 16 March 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Overlapping and Continued Alendronate or Raloxifene Administration in Patients on Teriparatide: Effects on Areal and Volumetric Bone Mineral Density The CONFORS Study.

        Nine month teriparatide (TPTD) monotherapy followed by co-administration of raloxifene (RAL) or alendronate (ALN) for another nine months resulted in incremental bone mineral density (BMD) increase. The aim of this study was... Lees meer

        Gepost op 16 March 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • FRAX without Bone Mineral Density Versus Osteoporosis Self-Assessment Screening Tool as Predictors of Osteoporosis in Primary Screening of Individuals Aged 70 and Older.

        To compare two well-validated tools-the FRAX without bone mineral density (BMD) and the Osteoporosis Self-Assessment Screening Tool (OST)-in predicting osteoporosis and to define thresholds above and below which it would be... Lees meer

        Gepost op 16 March 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Sclerostin and bone strength in women in their 10th decade of life.

        Sclerostin is a potent inhibitor of bone formation but has been shown to correlate positively with areal bone mineral density (aBMD). Little is known about its relationship to parameters of bone strength and volumetric BMD... Lees meer

        Gepost op 09 March 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Sharper view gained of osteoporosis development: Intracellular protein discovered

        In the bones supporting our bodies, calcium regulation occurs by balancing the activities of osteoclasts, which are groups of cells that increase the calcium concentration in blood by destroying bone tissue, and osteoblasts,... Lees meer

        Gepost op 09 March 2014

        Bron: http://feeds.sciencedaily.c....

      • Predicting fracture risk for treated, untreated patients

        A new study summarizes the clinical performance of serum procollagen type I N propeptide and serum C-terminal cross-linking telopeptide of type I collagen in fracture risk prediction in untreated individuals in prospective... Lees meer

        Gepost op 09 March 2014

        Bron: http://feeds.sciencedaily.c....

      • PINP as a biological response marker during teriparatide treatment for osteoporosis.

        Postmenopausal women with severe osteoporosis may require treatment with the bone anabolic drug teriparatide. While changes in bone mineral density (BMD) are one measure of response, BMD changes often require a minimum of... Lees meer

        Gepost op 09 March 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Prevalence of vertebral fractures and minor vertebral deformities evaluated by DXA-assisted vertebral fracture assessment (VFA) in a population-based study of postmenopausal women: the FRODOS study.

         Population-based studies performed with vertebral fracture assessment (VFA) morphometric technology are lacking in postmenopausal osteoporosis. In this study, we show a lower than expected prevalence of vertebral... Lees meer

        Gepost op 09 March 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • The spectrum of fractures in the elderly.

        Fractures in patients aged ≥ 65 years constitute an increasing burden on health and social care and are associated with a high morbidity and mortality. There is little accurate information about the epidemiology of... Lees meer

        Gepost op 05 March 2014

        Bron: http://www.ncbi.nlm.nih.gov....

      • Delayed/non‐union of upper limb fractures with bisphosphonates: systematic review and recommendations

        Differences in union time between BP users and non‐users are not significant enough to change current practice patterns and do not outweigh the benefits of BP therapy. There is no evidence to encourage early surgical... Lees meer

        Gepost op 02 March 2014

        Bron: http://www.medworm.com/inde....

      • Two Years of Denosumab and Teriparatide Administration in Postmenopausal Women with Osteoporosis (The DATA Extension Study): a Randomized Controlled Trial

        Two years of concomitant teriparatide and denosumab therapy increases BMD more than either medication alone and more than has been reported with any current therapy. The combination of these agents may prove to be an... Lees meer

        Gepost op 02 March 2014

        Bron: http://www.medworm.com/inde....

      • Antidepressant use and 10-year incident fracture risk: the population-based Canadian Multicentre Osteoporosis Study (CaMoS)

        We used data from a large, prospective Canadian cohort to assess the association between selective serotonin reuptake inhibitors (SSRIs) and serotonin and noradrenaline reuptake inhibitors (SNRIs) and fracture. We found an... Lees meer

        Gepost op 02 March 2014

        Bron: http://www.medworm.com/inde....

      • Osteoporosis Screening Strategies for Younger Postmenopausal WomenOsteoporosis Screening Strategies for Younger Postmenopausal Women

        None of the three common osteoporosis screening strategies is optimal for younger postmenopausal women, and the US Preventive Services Task Force (USPSTF) strategy is the worst. 

        Lees meer

        Gepost op 02 March 2014

        Bron: http://www.medworm.com/inde....

      • Fracture liaison service: impact on subsequent nonvertebral fracture incidence and mortality.

        CONCLUSIONS: Patients seen at the fracture liaison service had a significantly lower mortality and subsequently a lower risk of nonvertebral fracture than those not seen at the fracture liaison service, with a reduction of... Lees meer

        Gepost op 02 March 2014

        Bron: http://www.medworm.com/inde....

      • Rates of osteoporosis treatment after hip fracture on the decline

        The majority of patients with hip fracture do not receive osteoporosis treatment and the rates of treatment have been declining, a finding that is not consistent with osteoporosis treatment guidelines endorsed by the... Lees meer

        Gepost op 02 March 2014

        Bron: http://news.google.com/news....

      • Conventional assessment strategies identify more postmenopausal women with ...

        The U.S. Preventative Service Task Force recommendation of osteoporosis screening for women younger than 65 years was moderately better than chance alone, but inferior to conventional strategies, according to results of a... Lees meer

        Gepost op 05 February 2014

        Bron: http://news.google.com/news....

      • Patient Perceptions of Osteoporosis Treatment Thresholds.

        There is substantial variability in preferences for postmenopausal osteoporosis treatment. Presentation of individualized fracture risks as recommended by current guidelines has potential to allow better targeting to... Lees meer

        Gepost op 01 February 2014

        Bron: http://www.medworm.com/inde....

      • Osteoporosis/Osteopenia Prevalent in Chronic Pancreatitis

        Sixty-five percent of patients with chronic pancreatitis have osteoporosis or osteopenia, according to a meta-analysis published in the February issue of Clinical Gastroenterology and Hepatology.  »

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        Gepost op 31 January 2014

        Bron: http://news.google.com/news....

      • Finding could lead to new treatments for osteoporosis

        Scientists at Washington University School of Medicine in St. Louis have discovered what appears to be a potent stimulator of new bone growth. The finding could lead to new treatments for osteoporosis and other diseases that... Lees meer

        Gepost op 31 January 2014

        Bron: http://news.google.com/news....

      • Osteoporosis screening recommendations may miss two-thirds of women aged

        Using health data on women ages 50–64 from the Women's Health Initiative study, the researchers found that the current strategy would identify only 34 percent of women who actually had bone-mineral density in the... Lees meer

        Gepost op 30 January 2014

        Bron: http://news.google.com/news....

      • Scientists develop automated system that identifies high-risk osteoporosis ...

        An automated system that identifies high-risk osteoporosis patients being treated for fractures and can generate letters encouraging follow-up is an effective way to promote osteoporosis intervention and prevent future... Lees meer

        Gepost op 29 January 2014

        Bron: http://news.google.com/news....

      • Study Provides Guidance On Drug Holidays

        Doctors commonly recommend drug holidays, or breaks, from certain osteoporosis drugs due to the risks associated with these treatments. Yet little has been known about the ideal duration of... Lees meer

        Gepost op 15 January 2014

        Bron: http://news.google.com/news....

      • Changes in Bone Mineral Density After Parathyroidectomy in Elderly Patients With Primary Hyperparathyroidism

        In the United States, approximately 1.5 million fractures occur due to osteoporosis annually; over 1/3 are due to low-impact falls among the community-dwelling elderly. Primary hyperparathyroidism (pHPT), by increasing... Lees meer

        Gepost op 11 January 2014

        Bron: http://www.medworm.com/inde....

      • Effects of vitamin D supplements on bone mineral density: a systematic review and meta-analysis

        Continuing widespread use of vitamin D for osteoporosis prevention in community-dwelling adults without specific risk factors for vitamin D deficiency seems to be inappropriate. (Source: LANCET)

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        Gepost op 11 January 2014

        Bron: http://www.medworm.com/inde....

      • EU Panel Recommends Suspension of Protelos/Osseor

        After an in-depth analysis, the European Medicines Agency's Pharmacovigilance Risk Assessment Committee determined that the drug's risks outweigh its benefits for treating osteoporosis. 

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        Gepost op 10 January 2014

        Bron: http://www.medworm.com/inde....

      • Rheumatoid arthritis and incident fracture in women: a case-control study

        Given that women with RA have a greater risk of fracture compared to women without RA, these patients may be a suitable target population for anti-resorptive agents; however, larger studies are warranted. (Source: BMC... Lees meer

        Gepost op 09 January 2014

        Bron: http://www.medworm.com/inde....

      • New Osteoporosis Drug Could Change Treatment

        Drug Could Change Treatment

        The experimental drug, romosozumab, frees the body's ability to stimulate bone production by blocking biochemical signals that naturally inhibit bone formation, explained Dr. Michael... Lees meer

        Gepost op 03 January 2014

        Bron: http://news.google.com/news....

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