• Stichting IWO wordt bestuurd door artsen die werkzaam zijn in verschillende organisaties en specialismen, maar hetzelfde doel voor ogen hebben

  • Stichting IWO wordt bestuurd door artsen die werkzaam zijn in verschillende organisaties en specialismen, maar hetzelfde doel voor ogen hebben

Nieuws

Volg hier relevant internationaal nieuws over osteoporose. De nieuwsfeed bevat zowel doorgeplaatste artikelen, als publicaties uit de Osteoporose journalen. Klik hier voor rss-feeds.

 

  • The bone-fat interface: basic and clinical implications of marrow adiposity.

    Lancet Diabetes Endocrinol. 2014 Feb 19; Authors: Devlin MJ, Rosen CJ 

    Obesity and osteoporosis are two of the most common chronic disorders of the 21st century. Both are accompanied by significant morbidity.... Lees meer

    Gepost op 16 April 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men.

    Cochrane Database Syst Rev. 2014 Apr 14;4:CD000227 Authors: Avenell A, Mak JC, O'Connell D

    BACKGROUND: Vitamin D and related compounds have been used to prevent osteoporotic fractures in older people. This is... Lees meer

    Gepost op 16 April 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Osteoporosis drugs appear to impede cell membrane repair

    A class of drugs widely used to treat osteoporosis appears to impede a cell's ability to repair a protective outer membrane that helps determine what enters and exits, researchers report. The inability to quickly repair... Lees meer

    Gepost op 16 April 2014

    Bron: http://feeds.sciencedaily.c....

  • Capture the Fracture

    In April 2013, IOF officially launched the Capture the Fracture programme, a multi-stakeholder campaign to prevent secondary fractures due to osteoporosis through the implementation of Fracture Liaison Services (FLS)... Lees meer

    Gepost op 16 April 2014

    Bron: http://www.iofbonehealth.or....

  • Examining the impact of reimbursement on referral to bone density testing for older adults: 8 years of data from the Barwon Statistical Division, Australia.

    Arch Osteoporos. 2013;8(1-2):152 Authors: Brennan SL, Kotowicz MA, Sarah B, Leslie WD, Ebeling PR, Metge CJ, Dobbins AG, Pasco JA 

    INTRODUCTION: On April 1, 2007 Medicare Australia revised reimbursement... Lees meer

    Gepost op 13 April 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Hyperkyphosis, Kyphosis Progression, and Risk of Non-Spine Fractures in Older Community Dwelling Women: The Study of Osteoporotic Fractures (SOF).

    J Bone Miner Res. 2014 Apr 9; Authors: Kado DM, Miller-Martinez D, Lui LY, Cawthon P, Katzman WB, Hillier TA, Fink HA, Ensrud KE

    While accentuated kyphosis is associated with osteoporosis, it is unknown whether it... Lees meer

    Gepost op 13 April 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Inflammatory Markers and Risk of Hip Fracture in Older White Women: The Study of Osteoporotic Fractures.

    J Bone Miner Res. 2014 Apr 9; Authors: Barbour KE, Lui LY, Ensrud KE, Hillier TA, Leblanc ES, Ing SW, Hochberg MC, Cauley JA, for the Study of Osteoporotic Fractures (SOF) Research Group 

    Hip fractures are the... Lees meer

    Gepost op 13 April 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Low Serum Thyrotropin Level and Duration of Suppression as a Predictor of Major Osteoporotic Fractures - The OPENTHYRO Register Cohort.

    J Bone Miner Res. 2014 Apr 9; Authors: Abrahamsen B, Jørgensen HL, Laulund AS, Nybo M, Brix TH, Hegedüs L

    BACKGROUND: The relationship between thyrotoxicosis and osteoporotic fractures remains... Lees meer

    Gepost op 13 April 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Prevalence and determinants of osteoporosis in patients with type 1 and type 2 diabetes mellitus.

    BMC Endocr Disord. 2014 Apr 11;14(1):33 Authors: Leidig-Bruckner G, Grobholz S, Bruckner T, Scheidt-Nave C, Nawroth P, Schneider JG

    BACKGROUND: Increased risk of osteoporosis and its clinical significance in... Lees meer

    Gepost op 13 April 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • U.S. adults meeting 2010 American College of Rheumatology criteria for treatment and prevention of glucocorticoid-induced osteoporosis.

    Arthritis Care Res (Hoboken). 2014 Apr 9; Authors: Overman RA, Toliver JC, Yeh JY, Gourlay ML, Deal CL

    Background/Purpose: The American College of Rheumatology (ACR) updated its guidelines on the prevention and... Lees meer

    Gepost op 13 April 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • A service development study of the assessment and management of fracture risk in Parkinson's disease.

    J Neurol. 2014 Apr 10; Authors: Shribman S, Torsney KM, Noyce AJ, Giovannoni G, Fearnley J, Dobson R

    Parkinson's disease (PD) is associated with an increased risk of fragility fracture. FRAX and Qfracture are... Lees meer

    Gepost op 13 April 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Pharmacists Can Use FRAX to Identify Osteoporosis Risk

    The pharmacist can help prevent osteoporosis from occurring and, in those who already have the condition, help minimale risk for fracture, according to a presentation at the American Pharmacists Association (APhA) 2014... Lees meer

    Gepost op 13 April 2014

    Bron: http://news.google.com/news....

  • Trabecular Microfractures in the Femoral Head with Osteoporosis: Analysis of Microcallus Formations by Synchrotron Radiation Micro CT.

    Bone. 2014 Apr 2; Authors: Okazaki N, Chiba K, Taguchi K, Nango N, Kubota S, Ito M, Osaki M

    Trabecular bone microfracture pathogenesis and associated healing processes are not well understood. We analyzed the... Lees meer

    Gepost op 09 April 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Incremental Predictive Value of Sarcopenia for Incident Fracture in an Elderly Chinese Cohort: Results From the Osteoporotic Fractures in Men (MrOs) Study.

     J Am Med Dir Assoc. 2014 Apr 2; Authors: Yu R, Leung J, Woo J 

    OBJECTIVES: We examined whether sarcopenia is predictive of incident fractures among older men, whether the inclusion of sarcopenia in... Lees meer

    Gepost op 09 April 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Usefulness of bone density measurement in fallers.

    Joint Bone Spine. 2014 Apr 2; Authors: Blain H, Rolland Y, Beauchet O, Annweiler C, Benhamou CL, Benetos A, Berrut G, Audran M, Bendavid S, Bousson V, Briot K, Brazier M, Breuil V, Chapuis L, Chapurlat R, Cohen-Solal M,... Lees meer

    Gepost op 09 April 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • There is still a care gap in osteoporosis management for patients with rheumatoid arthritis.

    Joint Bone Spine. 2014 Apr 2; Authors: Watt J, Thompson A, Le Riche N, Pope J 

    OBJECTIVES: To assess compliance rates with the current Canadian osteoporosis guidelines and whether the Fracture Risk Assessment... Lees meer

    Gepost op 09 April 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Bone marrow fat.

    Joint Bone Spine. 2014 Apr 1; Authors: Hardouin P, Pansini V, Cortet B

    Bone marrow fat (BMF) results from an accumulation of fat cells within the bone marrow. Fat is not a simple filling tissue but is now... Lees meer

    Gepost op 09 April 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • International and ethnic variability of falls in older men.

    Scand J Public Health. 2014 Mar;42(2):194-200 Authors: Karlsson MK, Ribom EL, Nilsson JÅ, Karlsson C, Cöster M, Vonschewelov T, Mallmin H, Ljunggren Ö, Ohlsson C, Mellström D, Lorentzon M, Leung PC, Lau... Lees meer

    Gepost op 09 April 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Three New Reports of the IOF

    Providing evidence-based solutions Three groundbreaking new reports published by IOF in 2013 reveal the burden of osteoporosis in Europe and the Asia-Pacific. The reports are being used by national osteoporosis societies as... Lees meer

    Gepost op 09 April 2014

    Bron: http://www.iofbonehealth.or....

  • Interaction between Muscle and Bone.

     J Bone Metab. 2014 Feb;21(1):29-40 Authors: Kaji H

    The clinical significance of sarcopenia and osteoporosis has increased with the increase in the population of older people. Sarcopenia is defined by... Lees meer

    Gepost op 09 April 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Long-term risk of medical conditions associated with breast cancer treatment.

    Breast Cancer Res Treat. 2014 Apr 3; Authors: Hill DA, Horick NK, Isaacs C, Domchek SM, Tomlinson GE, Lowery JT, Kinney AY, Berg JS, Edwards KL, Moorman PG, Plon SE, Strong LC, Ziogas A, Griffin CA, Kasten CH, Finkelstein... Lees meer

    Gepost op 06 April 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Declining rates of osteoporosis management following fragility fractures in the u.s., 2000 through 2009.

     J Bone Joint Surg Am. 2014 Apr 2;96(7):e52 Authors: Balasubramanian A, Tosi LL, Lane JM, Dirschl DR, Ho PR, O'Malley CD  

    Clinical practice recommendations state that patients with fragility... Lees meer

    Gepost op 06 April 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • The global burden attributable to low bone mineral density.

    Ann Rheum Dis. 2014 Apr 1; Authors: Sànchez-Riera L, Carnahan E, Vos T, Veerman L, Norman R, Lim SS, Hoy D, Smith E, Wilson N, Nolla JM, Chen JS, Macara M, Kamalaraj N, Li Y, Kok C, Santos-Hernández C, March... Lees meer

    Gepost op 06 April 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Effects of up to 5 Years of Denosumab Treatment on Bone Histology and Histomorphometry: The FREEDOM Study Extension.

    J Bone Miner Res. 2014 Apr 1; Authors: Brown JP, Reid IR, Wagman RB, Kendler D, Miller PD, Jensen JE, Bolognese MA, Daizadeh N, Valter I, Zerbini CA, Dempster DW

    Denosumab reduced bone resorption, increased BMD,... Lees meer

    Gepost op 06 April 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Economic evaluation of an osteoporosis screening campaign using FRAX

    In new research presented at the World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases today, investigators showed that an osteoporosis screening strategy using FRAX as a pre-screening tool is... Lees meer

    Gepost op 06 April 2014

    Bron: http://news.google.com/news....

  • New FRAX app launched by the International Osteoporosis Foundation

    Osteoporosis management guidelines around the world now recommend that fracture risk assessment be part of any clinical evaluation for osteoporosis. As a result, rather than relying on bone mineral density values alone,... Lees meer

    Gepost op 06 April 2014

    Bron: http://news.google.com/news....

  • EMAS position statement: The management of postmenopausal women with vertebral osteoporotic fracture.

    Maturitas. 2014 Mar 7; Authors: Triantafyllopoulos IK, Lambropoulou-Adamidou K, Nacopoulos CC, Papaioannou NA, Ceausu I, Depypere H, Erel CT, Pérez-López FR, Schenck-Gustafsson K, van der Schouw YT, Simoncini... Lees meer

    Gepost op 02 April 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • TBS result is not affected by lumbar spine osteoarthritis.

    Osteoporos Int. 2014 Apr 1; Authors: Kolta S, Briot K, Fechtenbaum J, Paternotte S, Armbrecht G, Felsenberg D, Glüer CC, Eastell R, Roux C .

    INTRODUCTION: Lumbar... Lees meer

    Gepost op 02 April 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Patterns and predictors of osteoporosis medication discontinuation and switching among Medicare beneficiaries.

    BMC Musculoskelet Disord. 2014 Apr 1;15(1):112 Authors: Yun H, Curtis JR, Guo L, Kilgore M, Muntner P, Saag K, Matthews R, Morrisey M, Wright NC, Becker DJ, Delzell E 

    BACKGROUND: Low adherence to... Lees meer

    Gepost op 02 April 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Meta-analysis of risk factors for the second hip fracture (SHF) in elderly patients.

    Arch Gerontol Geriatr. 2014 Mar 20; Authors: Zhu Y, Chen W, Sun T, Zhang Q, Cheng J, Zhang Y

    This study aims to quantitatively summarize the risk factors for the incidence of SHF. A meta-analysis was performed with... Lees meer

    Gepost op 30 March 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • NCCN Task Force Report: Bone Health In Cancer Care.

    J Natl Compr Canc Netw. 2013 Aug;11 Suppl 3:S1-50; quiz S51 Authors: Gralow JR, Biermann JS, Farooki A, Fornier MN, Gagel RF, Kumar R, Litsas G, McKay R, Podoloff DA, Srinivas S, Van Poznak CH

    Bone health and... Lees meer

    Gepost op 30 March 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Alendronate-induced atypical bone fracture: evidence that the drug inhibits osteogenesis.

    J Clin Pharm Ther. 2014 Mar 24; Authors: Patntirapong S, Singhatanadgit W, Arphavasin S

    OBJECTIVE: Alendronate (ALN) is used for the treatment of post-menopausal osteoporosis. By reducing bone turnover, it... Lees meer

    Gepost op 30 March 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Predictors of Excess Mortality Following Fracture: A Population-Based Cohort Study.

    J Bone Miner Res. 2014 Feb 12; Authors: Melton LJ, Atkinson EJ, St Sauver JL, Achenbach SJ, Therneau TM, Rocca WA, Amin S

    To determine the extent to which excess mortality following fractures due to particular... Lees meer

    Gepost op 30 March 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Impacts of Body Mass Index, Physical Activity, and Smoking on Femoral Bone Loss. The Tromsø Study.

    J Bone Miner Res. 2014 Mar 28; Authors: Emaus N, Wilsgaard T, Ahmed LA

    Bone mineral density (BMD) is a reflection of bone strength and lifestyles that preserve bone mass may reduce fracture risk in old age. This... Lees meer

    Gepost op 30 March 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Age discrimination in osteoporosis screening—Data from the Aalborg University Hospital Record for Osteoporosis Risk Assessment (AURORA)

    We report data from the 8,131 consecutive evaluations in 7914 individuals at the Osteoporosis Clinic from January 1st 2010 through December 31st 2012.Results: Risk factor data were available in >96% and DXA in 98%.... Lees meer

    Gepost op 30 March 2014

    Bron: http://www.medworm.com/inde....

  • Melk drinken tijdens tienerjaren helpt niet om osteoporose te voorkomen

    Vaak wordt aangeraden om tijdens de kinder- en tienerjaren veel melk te drinken, om op die manier voldoende botmassa op te bouwen en op latere leeftijd botontkalking (osteoporose) te voorkomen. Een nieuw Amerikaans onderzoek... Lees meer

    Gepost op 30 March 2014

    Bron: http://news.google.com/news....

  • OPG and sRANKL serum levels and incident hip fracture in postmenopausal Caucasian women in the Women's Health Initiative Observational Study.

    Bone. 2013 Oct;56(2):474-81 Authors: LaCroix AZ, Jackson RD, Aragaki A, Kooperberg C, Cauley JA, Chen Z, Leboff MS, Duggan D, Wactawski-Wende J

    PURPOSE: The osteoprotogerin/receptor activator of NF-kappa... Lees meer

    Gepost op 25 March 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Use of strontium ranelate and risk of acute coronary syndrome: cohort study.

    Ann Rheum Dis. 2014 Mar 20; Authors: Svanström H, Pasternak B, Hviid A

    BACKGROUND: A recent pooled analysis of randomised trials found an increased risk of myocardial infarction with use of the... Lees meer

    Gepost op 25 March 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Early Changes in Bone Density, Micro-Architecture, Bone Resorption and Inflammation Predict the Clinical Outcome 12 Weeks After Conservatively Treated Distal Radius Fractures: An Exploratory Study.

    Fracture healing is an active process with early changes in bone and inflammation. We performed an exploratory study evaluating the association between early changes in densitometric, structural, biomechanical and... Lees meer

    Gepost op 22 March 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Effects of Odanacatib on the Radius and Tibia of Postmenopausal Women: Improvements in Bone Geometry, Microarchitecture and Estimated Bone Strength.

    The cathepsin K inhibitor odanacatib, currently in phase 3 development for postmenopausal osteoporosis, has a novel mechanism of action that reduces bone resorption while maintaining bone formation. In phase 2 studies,... Lees meer

    Gepost op 22 March 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Biochemical Markers of Bone Turnover in Chronic Obstructive Pulmonary Disease (COPD).

    Osteoporosis has a higher prevalence in COPD patients and its etiology is very complex, it has been linked with reduced physical activity, low body mass index (BMD), a worse degree of airflow limitation and... Lees meer

    Gepost op 19 March 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • The effects of bazedoxifene in the ovariectomized aged cynomolgus monkey.

    Bazedoxifene (BZA) is a novel selective estrogen receptor modulator in clinical development for the prevention and treatment of postmenopausal osteoporosis. This preclinical study evaluated the efficacy and safety of BZA in... Lees meer

    Gepost op 19 March 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Evaluation of the anti-osteoporotic effects of metformin and sitagliptin in postmenopausal diabetic women.

    Osteoporosis is the most important metabolic bone disease in patients with diabetes mellitus. Several studies have documented that metformin is osteogenic in vitro. In contrast, others showed no effect of metformin on the... Lees meer

    Gepost op 19 March 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Interrelationship among muscle, fat, and bone: Connecting the dots on cellular, hormonal, and whole body levels.

    While sarcopenia and sarcopenic obesity have been recognized in the last decade, a combined concept to include decreased muscle mass and strength, as well as decreased bone mass with coexistence of adiposity is discussed... Lees meer

    Gepost op 19 March 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • The association between plasma homocysteine levels and bone quality and bone mineral density parameters in older persons.

    INTRODUCTION: High plasma homocysteine levels have been associated with incident osteoporotic fractures, but the mechanisms underlying this association are still unknown. It has been hypothesized that homocysteine might... Lees meer

    Gepost op 19 March 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Clinical treatment outcomes for 40 patients with bisphosphonates-related osteonecrosis of the jaws.

    BACKGROUND/PURPOSE: Bisphosphonates (BPs) are used to treat osteoporosis and bone metastases from malignancy. They may result in BPs-related osteonecrosis of the jaws (BRONJ) in a subset of patients receiving BPs. This study... Lees meer

    Gepost op 19 March 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Serum periostin is associated with fracture risk in postmenopausal women: a 7 years prospective analysis of the OFELY study.

    Purpose: Periostin (POSTN) is a secreted gamma-carboxyglutamic acid-containing protein (Gla protein) expressed mainly in the periosteum in adult individuals. POSNT deficient mice develop periodontis and osteoporosis with... Lees meer

    Gepost op 19 March 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • National Bone Health Alliance Clinical Diagnosis of Osteoporosis Working ...

    The National Bone Health Alliance (NBHA) Clinical Diagnosis of Osteoporosis Working Group recommends expanding the criteria for making a diagnosis of osteoporosis to include all post-menopausal women and all men age 50 en... Lees meer

    Gepost op 19 March 2014

    Bron: http://news.google.com/news....

  • Bone mass behavior after 1 year of different treatment strategies in prostate cancer patients subjected to androgen deprivation therapy.

    The aim of this study was to evaluate bone mass changes after 1 year of four different types of pharmacological intervention. Ninety-seven prostate cancer patients treated with androgen deprivation therapy, and severe... Lees meer

    Gepost op 16 March 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Choice of Lumbar Spine Bone Density Reference Database for Fracture Prediction in Men and Women: A Population-Based Analysis.

    The diagnosis of osteoporosis in men is controversial, although most studies demonstrate similar fracture rates for men and women with the same level of hip bone mineral density (BMD). Whether this applies to the lumbar... Lees meer

    Gepost op 16 March 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Fracture incidence after 3 years of aromatase inhibitor therapy.

    BACKGROUND: The purpose of this study was to describe the fracture incidence and bone mineral density (BMD) evolution in a large cohort of post-menopausal women with breast cancer after 3 years of aromatase inhibitor (AI)... Lees meer

    Gepost op 16 March 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Mortality following the first hip fracture in Norwegian women and men 1999-2008. A NOREPOS study.

    Hip fractures are associated with increased mortality and their incidence in Norway is one of the highest worldwide. The aim of this nationwide study was to examine short and long term mortality after hip fractures, burden... Lees meer

    Gepost op 16 March 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Anti-osteoporotic drugs and vascular calcification: the bidirectional calcium traffic.

    During the last years, numerous epidemiological studies have demonstrated a direct relationship between vascular calcification and low bone mineral density. This observation is in line with experimental data demonstrating... Lees meer

    Gepost op 16 March 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Plasma level of homocysteine associated with severe vertebral fracture in postmenopausal women.

    The aim of this cross-sectional cohort study was to clarify risk factors for severe vertebral fractures in postmenopausal Japanese women. Subjects were ambulatory volunteers age over 50 years who were recruited from a... Lees meer

    Gepost op 16 March 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Overlapping and Continued Alendronate or Raloxifene Administration in Patients on Teriparatide: Effects on Areal and Volumetric Bone Mineral Density The CONFORS Study.

    Nine month teriparatide (TPTD) monotherapy followed by co-administration of raloxifene (RAL) or alendronate (ALN) for another nine months resulted in incremental bone mineral density (BMD) increase. The aim of this study was... Lees meer

    Gepost op 16 March 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • FRAX without Bone Mineral Density Versus Osteoporosis Self-Assessment Screening Tool as Predictors of Osteoporosis in Primary Screening of Individuals Aged 70 and Older.

    To compare two well-validated tools-the FRAX without bone mineral density (BMD) and the Osteoporosis Self-Assessment Screening Tool (OST)-in predicting osteoporosis and to define thresholds above and below which it would be... Lees meer

    Gepost op 16 March 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Sclerostin and bone strength in women in their 10th decade of life.

    Sclerostin is a potent inhibitor of bone formation but has been shown to correlate positively with areal bone mineral density (aBMD). Little is known about its relationship to parameters of bone strength and volumetric BMD... Lees meer

    Gepost op 09 March 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Sharper view gained of osteoporosis development: Intracellular protein discovered

    In the bones supporting our bodies, calcium regulation occurs by balancing the activities of osteoclasts, which are groups of cells that increase the calcium concentration in blood by destroying bone tissue, and osteoblasts,... Lees meer

    Gepost op 09 March 2014

    Bron: http://feeds.sciencedaily.c....

  • Predicting fracture risk for treated, untreated patients

    A new study summarizes the clinical performance of serum procollagen type I N propeptide and serum C-terminal cross-linking telopeptide of type I collagen in fracture risk prediction in untreated individuals in prospective... Lees meer

    Gepost op 09 March 2014

    Bron: http://feeds.sciencedaily.c....

  • PINP as a biological response marker during teriparatide treatment for osteoporosis.

    Postmenopausal women with severe osteoporosis may require treatment with the bone anabolic drug teriparatide. While changes in bone mineral density (BMD) are one measure of response, BMD changes often require a minimum of... Lees meer

    Gepost op 09 March 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Prevalence of vertebral fractures and minor vertebral deformities evaluated by DXA-assisted vertebral fracture assessment (VFA) in a population-based study of postmenopausal women: the FRODOS study.

     Population-based studies performed with vertebral fracture assessment (VFA) morphometric technology are lacking in postmenopausal osteoporosis. In this study, we show a lower than expected prevalence of vertebral... Lees meer

    Gepost op 09 March 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • The spectrum of fractures in the elderly.

    Fractures in patients aged ≥ 65 years constitute an increasing burden on health and social care and are associated with a high morbidity and mortality. There is little accurate information about the epidemiology of... Lees meer

    Gepost op 05 March 2014

    Bron: http://www.ncbi.nlm.nih.gov....

  • Effects of a short-term whole body vibration intervention on bone mass and structure in elderly people

    Objectives: We aimed to clarify whether a short-term whole body vibration training has a beneficial effect on bone mass and structure in elderly men and women.Design: Randomised controlled trial.Methods: A total of 49... Lees meer

    Gepost op 02 March 2014

    Bron: http://www.medworm.com/inde....

  • Influence of number of deliveries and total breast-feeding time on bone mineral density in premenopausal and young postmenopausal women

    This study sought to determine if pregnancy or breast-feeding or both have a cumulative effect on BMD in premenopausal and early postmenopausal women.Study design: We performed single-center cohort analysis. Five hundred... Lees meer

    Gepost op 02 March 2014

    Bron: http://www.medworm.com/inde....

  • Vitamin D deficiency and coronary artery disease: A review of the evidence

    Coronary artery disease remains the leading cause of death in developed countries despite significant progress in primary prevention and treatment strategies. Older patients are at particularly high risk of poor outcomes... Lees meer

    Gepost op 02 March 2014

    Bron: http://www.medworm.com/inde....

  • Prediction of vitamin D deficiency by simple patient characteristics.

    CONCLUSIONS: Two total risk scores, including 13 or 10 predictors that can easily be assessed, were developed and are able to predict serum 25(OH)D concentrations <50 and <30 nmol/L accurately. These risk scores may be... Lees meer

    Gepost op 02 March 2014

    Bron: http://www.medworm.com/inde....

  • Delayed/non‐union of upper limb fractures with bisphosphonates: systematic review and recommendations

    Differences in union time between BP users and non‐users are not significant enough to change current practice patterns and do not outweigh the benefits of BP therapy. There is no evidence to encourage early surgical... Lees meer

    Gepost op 02 March 2014

    Bron: http://www.medworm.com/inde....

  • Two Years of Denosumab and Teriparatide Administration in Postmenopausal Women with Osteoporosis (The DATA Extension Study): a Randomized Controlled Trial

    Two years of concomitant teriparatide and denosumab therapy increases BMD more than either medication alone and more than has been reported with any current therapy. The combination of these agents may prove to be an... Lees meer

    Gepost op 02 March 2014

    Bron: http://www.medworm.com/inde....

  • Antidepressant use and 10-year incident fracture risk: the population-based Canadian Multicentre Osteoporosis Study (CaMoS)

    We used data from a large, prospective Canadian cohort to assess the association between selective serotonin reuptake inhibitors (SSRIs) and serotonin and noradrenaline reuptake inhibitors (SNRIs) and fracture. We found an... Lees meer

    Gepost op 02 March 2014

    Bron: http://www.medworm.com/inde....

  • Osteoporosis Screening Strategies for Younger Postmenopausal WomenOsteoporosis Screening Strategies for Younger Postmenopausal Women

    None of the three common osteoporosis screening strategies is optimal for younger postmenopausal women, and the US Preventive Services Task Force (USPSTF) strategy is the worst. 

    Lees meer

    Gepost op 02 March 2014

    Bron: http://www.medworm.com/inde....

  • Fracture liaison service: impact on subsequent nonvertebral fracture incidence and mortality.

    CONCLUSIONS: Patients seen at the fracture liaison service had a significantly lower mortality and subsequently a lower risk of nonvertebral fracture than those not seen at the fracture liaison service, with a reduction of... Lees meer

    Gepost op 02 March 2014

    Bron: http://www.medworm.com/inde....

  • Rates of osteoporosis treatment after hip fracture on the decline

    The majority of patients with hip fracture do not receive osteoporosis treatment and the rates of treatment have been declining, a finding that is not consistent with osteoporosis treatment guidelines endorsed by the... Lees meer

    Gepost op 02 March 2014

    Bron: http://news.google.com/news....

  • Seasonal Vitamin D Changes and the Impact on Health Risk Assessment.

    This retrospective epidemiological study demonstrates seasonal variation of vitamin D levels at clinical decision points. Although not unexpected, this variation has an impact on studies relating low vitamin D levels to... Lees meer

    Gepost op 10 February 2014

    Bron: http://www.medworm.com/inde....

  • Conventional assessment strategies identify more postmenopausal women with ...

    The U.S. Preventative Service Task Force recommendation of osteoporosis screening for women younger than 65 years was moderately better than chance alone, but inferior to conventional strategies, according to results of a... Lees meer

    Gepost op 05 February 2014

    Bron: http://news.google.com/news....

  • Patient Perceptions of Osteoporosis Treatment Thresholds.

    There is substantial variability in preferences for postmenopausal osteoporosis treatment. Presentation of individualized fracture risks as recommended by current guidelines has potential to allow better targeting to... Lees meer

    Gepost op 01 February 2014

    Bron: http://www.medworm.com/inde....

  • Osteoporosis/Osteopenia Prevalent in Chronic Pancreatitis

    Sixty-five percent of patients with chronic pancreatitis have osteoporosis or osteopenia, according to a meta-analysis published in the February issue of Clinical Gastroenterology and Hepatology.  »

    Lees meer

    Gepost op 31 January 2014

    Bron: http://news.google.com/news....

  • Finding could lead to new treatments for osteoporosis

    Scientists at Washington University School of Medicine in St. Louis have discovered what appears to be a potent stimulator of new bone growth. The finding could lead to new treatments for osteoporosis and other diseases that... Lees meer

    Gepost op 31 January 2014

    Bron: http://news.google.com/news....

  • Osteoporosis screening recommendations may miss two-thirds of women aged

    Using health data on women ages 50–64 from the Women's Health Initiative study, the researchers found that the current strategy would identify only 34 percent of women who actually had bone-mineral density in the... Lees meer

    Gepost op 30 January 2014

    Bron: http://news.google.com/news....

  • Scientists develop automated system that identifies high-risk osteoporosis ...

    An automated system that identifies high-risk osteoporosis patients being treated for fractures and can generate letters encouraging follow-up is an effective way to promote osteoporosis intervention and prevent future... Lees meer

    Gepost op 29 January 2014

    Bron: http://news.google.com/news....

  • Study Provides Guidance On Drug Holidays

    Doctors commonly recommend drug holidays, or breaks, from certain osteoporosis drugs due to the risks associated with these treatments. Yet little has been known about the ideal duration of... Lees meer

    Gepost op 15 January 2014

    Bron: http://news.google.com/news....

  • Changes in Bone Mineral Density After Parathyroidectomy in Elderly Patients With Primary Hyperparathyroidism

    In the United States, approximately 1.5 million fractures occur due to osteoporosis annually; over 1/3 are due to low-impact falls among the community-dwelling elderly. Primary hyperparathyroidism (pHPT), by increasing... Lees meer

    Gepost op 11 January 2014

    Bron: http://www.medworm.com/inde....

  • Effects of vitamin D supplements on bone mineral density: a systematic review and meta-analysis

    Continuing widespread use of vitamin D for osteoporosis prevention in community-dwelling adults without specific risk factors for vitamin D deficiency seems to be inappropriate. (Source: LANCET)

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    Gepost op 11 January 2014

    Bron: http://www.medworm.com/inde....

  • EU Panel Recommends Suspension of Protelos/Osseor

    After an in-depth analysis, the European Medicines Agency's Pharmacovigilance Risk Assessment Committee determined that the drug's risks outweigh its benefits for treating osteoporosis. 

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    Gepost op 10 January 2014

    Bron: http://www.medworm.com/inde....

  • Rheumatoid arthritis and incident fracture in women: a case-control study

    Given that women with RA have a greater risk of fracture compared to women without RA, these patients may be a suitable target population for anti-resorptive agents; however, larger studies are warranted. (Source: BMC... Lees meer

    Gepost op 09 January 2014

    Bron: http://www.medworm.com/inde....

  • New Osteoporosis Drug Could Change Treatment

    Drug Could Change Treatment

    The experimental drug, romosozumab, frees the body's ability to stimulate bone production by blocking biochemical signals that naturally inhibit bone formation, explained Dr. Michael... Lees meer

    Gepost op 03 January 2014

    Bron: http://news.google.com/news....

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